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Q9RTI9

- Q9RTI9_DEIRA

UniProt

Q9RTI9 - Q9RTI9_DEIRA

Protein
Submitted name:

DNA helicase II

Gene

DR_1775

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + H2O = ADP + phosphate.SAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121ATPanalog; via carbonyl oxygenImported
    Binding sitei17 – 171ATPanalogImported
    Binding sitei258 – 2581ATPanalogImported
    Binding sitei577 – 5771ATPanalogImported
    Binding sitei617 – 6171ATPanalogImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 406ATPanalogImported
    Nucleotide bindingi290 – 2912ATPanalogImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent DNA helicase activity Source: InterPro
    3. DNA binding Source: InterPro

    Keywords - Molecular functioni

    HelicaseSAAS annotationImported, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-1807-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DNA helicase IIImported
    Gene namesi
    Ordered Locus Names:DR_1775Imported
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9RTI9.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48319N.
    STRINGi243230.DR_1775.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C2TX-ray4.00A/B/C/D1-745[»]
    4C2UX-ray2.55A/D1-665[»]
    4C30X-ray3.00A/D/F/I1-665[»]
    ProteinModelPortaliQ9RTI9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000033016.
    KOiK03657.
    OMAiTEHDEAN.
    OrthoDBiEOG64N9TW.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR014017. DNA_helicase_UvrD-like_C.
    IPR000212. DNA_helicase_UvrD/REP.
    IPR027417. P-loop_NTPase.
    IPR014016. UvrD-like_ATP-bd.
    [Graphical view]
    PANTHERiPTHR11070. PTHR11070. 1 hit.
    PfamiPF00580. UvrD-helicase. 1 hit.
    PF13361. UvrD_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
    PS51217. UVRD_HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RTI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSAGPDLL QALNPTQAQA ADHFTGPALV IAGAGSGKTR TLIYRIAHLI    50
    GHYGVHPGEI LAVTFTNKAA AEMRERAGHL VPGAGDLWMS TFHSAGVRIL 100
    RTYGEHIGLR RGFVIYDDDD QLDIIKEVMG SIPGIGAETQ PRVIRGIIDR 150
    AKSNLWTPDD LDRSREPFIS GLPRDAAAEA YRRYEVRKKG QNAIDFGDLI 200
    TETVRLFKEV PGVLDKVQNK AKFIHVDEYQ DTNRAQYELT RLLASRDRNL 250
    LVVGDPDQSI YKFRGADIQN ILDFQKDYPD AKVYMLEHNY RSSARVLEAA 300
    NKLIENNTER LDKTLKPVKE AGQPVTFHRA TDHRAEGDYV ADWLTRLHGE 350
    GRAWSEMAIL YRTNAQSRVI EESLRRVQIP ARIVGGVGFY DRREIRDILA 400
    YARLALNPAD DVALRRIIGR PRRGIGDTAL QKLMEWARTH HTSVLTACAN 450
    AAEQNILDRG AHKATEFAGL MEAMSEAADN YEPAAFLRFV METSGYLDLL 500
    RQEGQEGQVR LENLEELVSA AEEWSQDEAN VGGSIADFLD DAALLSSVDD 550
    MRTKAENKGA PEDAVTLMTL HNAKGLEFPV VFIVGVEQGL LPSKGAIAEG 600
    PSGIEEERRL FYVGITRAME RLLMTAAQNR MQFGKTNAAE DSAFLEDIEG 650
    LFDTVDPYGQ PIEYRAKTWK QYRPTVPAAT TAVKNTSPLT AELAYRGGEQ 700
    VKHPKFGEGQ VLAVAGVGER QEVTVHFASA GTKKLMVKFA NLTKL 745
    Length:745
    Mass (Da):82,597
    Last modified:May 1, 2000 - v1
    Checksum:iA4946F40E5FCD309
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11329.1.
    PIRiE75354.
    RefSeqiNP_295498.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11329; AAF11329; DR_1775.
    GeneIDi1800142.
    KEGGidra:DR_1775.
    PATRICi21631186. VBIDeiRad64572_1987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11329.1 .
    PIRi E75354.
    RefSeqi NP_295498.1. NC_001263.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C2T X-ray 4.00 A/B/C/D 1-745 [» ]
    4C2U X-ray 2.55 A/D 1-665 [» ]
    4C30 X-ray 3.00 A/D/F/I 1-665 [» ]
    ProteinModelPortali Q9RTI9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48319N.
    STRINGi 243230.DR_1775.

    Proteomic databases

    PRIDEi Q9RTI9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11329 ; AAF11329 ; DR_1775 .
    GeneIDi 1800142.
    KEGGi dra:DR_1775.
    PATRICi 21631186. VBIDeiRad64572_1987.

    Phylogenomic databases

    HOGENOMi HOG000033016.
    KOi K03657.
    OMAi TEHDEAN.
    OrthoDBi EOG64N9TW.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-1807-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR014017. DNA_helicase_UvrD-like_C.
    IPR000212. DNA_helicase_UvrD/REP.
    IPR027417. P-loop_NTPase.
    IPR014016. UvrD-like_ATP-bd.
    [Graphical view ]
    PANTHERi PTHR11070. PTHR11070. 1 hit.
    Pfami PF00580. UvrD-helicase. 1 hit.
    PF13361. UvrD_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
    PS51217. UVRD_HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.
    2. "Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD."
      Stelter M., Acajjaoui S., McSweeney S., Timmins J.
      PLoS ONE 8:e77364-e77364(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-665 IN COMPLEX WITH ATPANALOG.

    Entry informationi

    Entry nameiQ9RTI9_DEIRA
    AccessioniPrimary (citable) accession number: Q9RTI9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3