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Protein

DNA helicase

Gene

DR_1775

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121ATP analog; via carbonyl oxygenCombined sources
Binding sitei17 – 171ATP analogCombined sources
Binding sitei258 – 2581ATP analogCombined sources
Binding sitei577 – 5771ATP analogCombined sources
Binding sitei617 – 6171ATP analogCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 406ATP analogCombined sources
Nucleotide bindingi290 – 2912ATP analogCombined sources

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent DNA helicase activity Source: InterPro
  3. DNA binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotationImported, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1807-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Ordered Locus Names:DR_1775Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524 Componenti: Chromosome I

PTM / Processingi

Proteomic databases

PRIDEiQ9RTI9.

Interactioni

Protein-protein interaction databases

DIPiDIP-48319N.
STRINGi243230.DR_1775.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C2TX-ray4.00A/B/C/D1-745[»]
4C2UX-ray2.55A/D1-665[»]
4C30X-ray3.00A/D/F/I1-665[»]
ProteinModelPortaliQ9RTI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000033016.
InParanoidiQ9RTI9.
KOiK03657.
OMAiVLDVHNT.
OrthoDBiEOG64N9TW.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 1 hit.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RTI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSAGPDLL QALNPTQAQA ADHFTGPALV IAGAGSGKTR TLIYRIAHLI
60 70 80 90 100
GHYGVHPGEI LAVTFTNKAA AEMRERAGHL VPGAGDLWMS TFHSAGVRIL
110 120 130 140 150
RTYGEHIGLR RGFVIYDDDD QLDIIKEVMG SIPGIGAETQ PRVIRGIIDR
160 170 180 190 200
AKSNLWTPDD LDRSREPFIS GLPRDAAAEA YRRYEVRKKG QNAIDFGDLI
210 220 230 240 250
TETVRLFKEV PGVLDKVQNK AKFIHVDEYQ DTNRAQYELT RLLASRDRNL
260 270 280 290 300
LVVGDPDQSI YKFRGADIQN ILDFQKDYPD AKVYMLEHNY RSSARVLEAA
310 320 330 340 350
NKLIENNTER LDKTLKPVKE AGQPVTFHRA TDHRAEGDYV ADWLTRLHGE
360 370 380 390 400
GRAWSEMAIL YRTNAQSRVI EESLRRVQIP ARIVGGVGFY DRREIRDILA
410 420 430 440 450
YARLALNPAD DVALRRIIGR PRRGIGDTAL QKLMEWARTH HTSVLTACAN
460 470 480 490 500
AAEQNILDRG AHKATEFAGL MEAMSEAADN YEPAAFLRFV METSGYLDLL
510 520 530 540 550
RQEGQEGQVR LENLEELVSA AEEWSQDEAN VGGSIADFLD DAALLSSVDD
560 570 580 590 600
MRTKAENKGA PEDAVTLMTL HNAKGLEFPV VFIVGVEQGL LPSKGAIAEG
610 620 630 640 650
PSGIEEERRL FYVGITRAME RLLMTAAQNR MQFGKTNAAE DSAFLEDIEG
660 670 680 690 700
LFDTVDPYGQ PIEYRAKTWK QYRPTVPAAT TAVKNTSPLT AELAYRGGEQ
710 720 730 740
VKHPKFGEGQ VLAVAGVGER QEVTVHFASA GTKKLMVKFA NLTKL
Length:745
Mass (Da):82,597
Last modified:May 1, 2000 - v1
Checksum:iA4946F40E5FCD309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11329.1.
PIRiE75354.
RefSeqiNP_295498.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11329; AAF11329; DR_1775.
GeneIDi1800142.
KEGGidra:DR_1775.
PATRICi21631186. VBIDeiRad64572_1987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11329.1.
PIRiE75354.
RefSeqiNP_295498.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C2TX-ray4.00A/B/C/D1-745[»]
4C2UX-ray2.55A/D1-665[»]
4C30X-ray3.00A/D/F/I1-665[»]
ProteinModelPortaliQ9RTI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48319N.
STRINGi243230.DR_1775.

Proteomic databases

PRIDEiQ9RTI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11329; AAF11329; DR_1775.
GeneIDi1800142.
KEGGidra:DR_1775.
PATRICi21631186. VBIDeiRad64572_1987.

Phylogenomic databases

HOGENOMiHOG000033016.
InParanoidiQ9RTI9.
KOiK03657.
OMAiVLDVHNT.
OrthoDBiEOG64N9TW.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1807-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 1 hit.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.
  2. "Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD."
    Stelter M., Acajjaoui S., McSweeney S., Timmins J.
    PLoS ONE 8:e77364-e77364(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-665 IN COMPLEX WITH ATP ANALOG.

Entry informationi

Entry nameiQ9RTI9_DEIRA
AccessioniPrimary (citable) accession number: Q9RTI9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.