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Q9RTI6 (LEUC2_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase large subunit 2
EC=4.2.1.33
Alternative name(s):
Alpha-IPM isomerase 2
Short name=IPMI 2
Isopropylmalate isomerase 2
Gene names
Name:leuC2
Ordered Locus Names:DR_1778
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus ›

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity. HAMAP-Rule MF_01027

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. HAMAP-Rule MF_01027

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. HAMAP-Rule MF_01027

Subunit structure

Heterodimer of LeuC and LeuD By similarity.

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4314313-isopropylmalate dehydratase large subunit 2 HAMAP-Rule MF_01027
PRO_0000076857

Sites

Metal binding3011Iron-sulfur (4Fe-4S) By similarity
Metal binding3611Iron-sulfur (4Fe-4S) By similarity
Metal binding3641Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RTI6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2CAF9A57247AAE01

FASTA43146,177
        10         20         30         40         50         60 
MGMTIAEKML AAHSGHDTVV PGQLIECATD WVLCHEITTP AALRMLEERG MDRVFDPQKI 

        70         80         90        100        110        120 
VAVPDHSVPA MNIKAAKMYQ KLKSWVQEKG IEHFYDVGRG GIAHVVLENT GLMKPGQTLV 

       130        140        150        160        170        180 
SGDSHTCNAG ALGAFATGVG STDLAGAIYA GKVWFKVPET MLIRVTGKTN PGVTPKDIVL 

       190        200        210        220        230        240 
EVIKQIGADG ANYMVMEWVG DYIDQLDMEG RFTLTNMAIE AGGKTGIVAV DDTTRAYMQQ 

       250        260        270        280        290        300 
RGVSPEQYTE YQSDPDAKYK VVVEIDAAQV EPTVAYPHIP SNGRVAGSDR IRVTHAYVGS 

       310        320        330        340        350        360 
CTNGRITDLR DVARILKGRK VAQDVQMIVV PATQAIWKQA AQEGLLEIFV DAGASVSYPS 

       370        380        390        400        410        420 
CGACLGMHSG VLGPDDICIS SSNRNFVGRM GDPSAQIYLA SPATVAASAV EGFIADPRRY 

       430 
DAEGNDLNAA D

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000513 Genomic DNA. Translation: AAF11331.1.
PIRH75354.
RefSeqNP_295501.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RTI6.
ModBaseSearch...

Protein-protein interaction databases

STRING243230.DR_1778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF11331; AAF11331; DR_1778.
GeneID1799112.
KEGGdra:DR_1778.
PATRIC21631192. VBIDeiRad64572_1990.

Phylogenomic databases

eggNOGCOG0065.
HOGENOMHOG000226971.
KOK01703.
OMAYFEVGKM.
ProtClustDBPRK00402.

Enzyme and pathway databases

BioCycDRAD243230:GH46-2147-MONOMER.
UniPathwayUPA00048; UER00071.

Family and domain databases

Gene3D3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
HAMAPMF_01027. LeuC_type2.
InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR011826. HAcnase/IPMdehydase_lsu_prok.
IPR006251. Homoacnase/IPMdehydase_lsu.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF6. PTHR11670:SF6. 1 hit.
PfamPF00330. Aconitase. 2 hits.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01343. hacA_fam. 1 hit.
TIGR02086. IPMI_arch. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLEUC2_DEIRA
AccessionPrimary (citable) accession number: Q9RTI6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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