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Q9RTF5

- GCSP_DEIRA

UniProt

Q9RTF5 - GCSP_DEIRA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-1841-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:DR_1809
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_0000166912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei697 – 6971N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ9RTF5.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi243230.DR_1809.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RTF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RTF5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSLSDLLQ TNDFTRRHIG PSEAEQAEML GVLGVSSLDE LTQTTLPAAI    50
    QFDGELHTGP GMTEAQALAE LKAVAQKNKV FRSYIGMGYA GTDVPPVILR 100
    NMLENPGWYT AYTPYQAEIS QGRLEMLLNF QQTVQDMTGM PVSNASLLDE 150
    ATAAAEAMTL AKRQSKNKGS NVFFVADNVH PQTMDVVKTR AEYFGFEVQT 200
    GSADAIPEGA FGALVQYPGT HGEVLNLAPI AEKAHTQGAA LIVATDLLAC 250
    ALLTPPGEQG ADIVVGSAQR FGVPMGFGGP HAAFLACQKG FERSMPGRVI 300
    GVSKDVRGNT ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAAYAVWH 350
    GPEGIKTIAE RVHRLTGILA KALQDAGIKA NETFFDTLTF EGQDDLGARA 400
    EAKGINFRLD GGKVGISLDE TVTPQDLADI IEVVTGKGVD VQKLDAEAVD 450
    GIPAPLKRQS DFLTHPVFNT HHSEHGMLRY LKQLENKDYS LTHGMIPLGS 500
    CTMKLNATTE MIPVTWPEFG GLHPFAPESQ TQGYAEMLAE LERWLADITG 550
    YDAVSMQPNS GAQGEYAGLL VIRKYHEARG EAHRNICLIP ASAHGTNPAS 600
    AAMMGMQVVV VKTDEQGNID FDDLKAQAEA HSDHLAALMI TYPSTHGVYE 650
    ENVRDVCDLI HQHGGQVYLD GANMNAMVGV AKPGLIGGDV SHLNLHKTFA 700
    IPHGGGGPGM GPIGVKAHLA PFLPNHAVAP TSDSHTGAVS AAPYGSASIL 750
    PISYLYIKLL GAAGLRQSTQ VALLNANYIA KRLSGAFPVL YSGKGGRVAH 800
    ECILDIRPLK QESGVSEEDI AKRLMDYGFH APTMSFPVPG TLMIEPTESE 850
    PKAELDRFVD AMLNIRREIQ DVQDGTISAA DSPLKHAPHT LKDLMDSEWT 900
    RAYSRETGAF PSAAQKAWKY WPAVNRVDNV YGDRNFVCSC PPIEDYIGA 949
    Length:949
    Mass (Da):102,123
    Last modified:May 1, 2000 - v1
    Checksum:iFDCBA42D4E0888D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11360.1.
    PIRiE75352.
    RefSeqiNP_295532.1. NC_001263.1.
    WP_010888444.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11360; AAF11360; DR_1809.
    GeneIDi1798625.
    KEGGidra:DR_1809.
    PATRICi21631254. VBIDeiRad64572_2021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11360.1 .
    PIRi E75352.
    RefSeqi NP_295532.1. NC_001263.1.
    WP_010888444.1. NC_001263.1.

    3D structure databases

    ProteinModelPortali Q9RTF5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_1809.

    Proteomic databases

    PRIDEi Q9RTF5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11360 ; AAF11360 ; DR_1809 .
    GeneIDi 1798625.
    KEGGi dra:DR_1809.
    PATRICi 21631254. VBIDeiRad64572_2021.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-1841-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiGCSP_DEIRA
    AccessioniPrimary (citable) accession number: Q9RTF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3