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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1841-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:DR_1809
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_0000166912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei697 – 6971N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ9RTF5.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_1809.

Structurei

3D structure databases

ProteinModelPortaliQ9RTF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiQ9RTF5.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RTF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSLSDLLQ TNDFTRRHIG PSEAEQAEML GVLGVSSLDE LTQTTLPAAI
60 70 80 90 100
QFDGELHTGP GMTEAQALAE LKAVAQKNKV FRSYIGMGYA GTDVPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQAEIS QGRLEMLLNF QQTVQDMTGM PVSNASLLDE
160 170 180 190 200
ATAAAEAMTL AKRQSKNKGS NVFFVADNVH PQTMDVVKTR AEYFGFEVQT
210 220 230 240 250
GSADAIPEGA FGALVQYPGT HGEVLNLAPI AEKAHTQGAA LIVATDLLAC
260 270 280 290 300
ALLTPPGEQG ADIVVGSAQR FGVPMGFGGP HAAFLACQKG FERSMPGRVI
310 320 330 340 350
GVSKDVRGNT ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAAYAVWH
360 370 380 390 400
GPEGIKTIAE RVHRLTGILA KALQDAGIKA NETFFDTLTF EGQDDLGARA
410 420 430 440 450
EAKGINFRLD GGKVGISLDE TVTPQDLADI IEVVTGKGVD VQKLDAEAVD
460 470 480 490 500
GIPAPLKRQS DFLTHPVFNT HHSEHGMLRY LKQLENKDYS LTHGMIPLGS
510 520 530 540 550
CTMKLNATTE MIPVTWPEFG GLHPFAPESQ TQGYAEMLAE LERWLADITG
560 570 580 590 600
YDAVSMQPNS GAQGEYAGLL VIRKYHEARG EAHRNICLIP ASAHGTNPAS
610 620 630 640 650
AAMMGMQVVV VKTDEQGNID FDDLKAQAEA HSDHLAALMI TYPSTHGVYE
660 670 680 690 700
ENVRDVCDLI HQHGGQVYLD GANMNAMVGV AKPGLIGGDV SHLNLHKTFA
710 720 730 740 750
IPHGGGGPGM GPIGVKAHLA PFLPNHAVAP TSDSHTGAVS AAPYGSASIL
760 770 780 790 800
PISYLYIKLL GAAGLRQSTQ VALLNANYIA KRLSGAFPVL YSGKGGRVAH
810 820 830 840 850
ECILDIRPLK QESGVSEEDI AKRLMDYGFH APTMSFPVPG TLMIEPTESE
860 870 880 890 900
PKAELDRFVD AMLNIRREIQ DVQDGTISAA DSPLKHAPHT LKDLMDSEWT
910 920 930 940
RAYSRETGAF PSAAQKAWKY WPAVNRVDNV YGDRNFVCSC PPIEDYIGA
Length:949
Mass (Da):102,123
Last modified:May 1, 2000 - v1
Checksum:iFDCBA42D4E0888D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11360.1.
PIRiE75352.
RefSeqiNP_295532.1. NC_001263.1.
WP_010888444.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11360; AAF11360; DR_1809.
GeneIDi1798625.
KEGGidra:DR_1809.
PATRICi21631254. VBIDeiRad64572_2021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11360.1.
PIRiE75352.
RefSeqiNP_295532.1. NC_001263.1.
WP_010888444.1. NC_001263.1.

3D structure databases

ProteinModelPortaliQ9RTF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1809.

Proteomic databases

PRIDEiQ9RTF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11360; AAF11360; DR_1809.
GeneIDi1798625.
KEGGidra:DR_1809.
PATRICi21631254. VBIDeiRad64572_2021.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiQ9RTF5.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1841-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiGCSP_DEIRA
AccessioniPrimary (citable) accession number: Q9RTF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.