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Q9RTF5

- GCSP_DEIRA

UniProt

Q9RTF5 - GCSP_DEIRA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, DR_1809
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1841-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:DR_1809
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei697 – 6971N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ9RTF5.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi243230.DR_1809.

Structurei

3D structure databases

ProteinModelPortaliQ9RTF5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RTF5-1 [UniParc]FASTAAdd to Basket

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MTKSLSDLLQ TNDFTRRHIG PSEAEQAEML GVLGVSSLDE LTQTTLPAAI    50
QFDGELHTGP GMTEAQALAE LKAVAQKNKV FRSYIGMGYA GTDVPPVILR 100
NMLENPGWYT AYTPYQAEIS QGRLEMLLNF QQTVQDMTGM PVSNASLLDE 150
ATAAAEAMTL AKRQSKNKGS NVFFVADNVH PQTMDVVKTR AEYFGFEVQT 200
GSADAIPEGA FGALVQYPGT HGEVLNLAPI AEKAHTQGAA LIVATDLLAC 250
ALLTPPGEQG ADIVVGSAQR FGVPMGFGGP HAAFLACQKG FERSMPGRVI 300
GVSKDVRGNT ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAAYAVWH 350
GPEGIKTIAE RVHRLTGILA KALQDAGIKA NETFFDTLTF EGQDDLGARA 400
EAKGINFRLD GGKVGISLDE TVTPQDLADI IEVVTGKGVD VQKLDAEAVD 450
GIPAPLKRQS DFLTHPVFNT HHSEHGMLRY LKQLENKDYS LTHGMIPLGS 500
CTMKLNATTE MIPVTWPEFG GLHPFAPESQ TQGYAEMLAE LERWLADITG 550
YDAVSMQPNS GAQGEYAGLL VIRKYHEARG EAHRNICLIP ASAHGTNPAS 600
AAMMGMQVVV VKTDEQGNID FDDLKAQAEA HSDHLAALMI TYPSTHGVYE 650
ENVRDVCDLI HQHGGQVYLD GANMNAMVGV AKPGLIGGDV SHLNLHKTFA 700
IPHGGGGPGM GPIGVKAHLA PFLPNHAVAP TSDSHTGAVS AAPYGSASIL 750
PISYLYIKLL GAAGLRQSTQ VALLNANYIA KRLSGAFPVL YSGKGGRVAH 800
ECILDIRPLK QESGVSEEDI AKRLMDYGFH APTMSFPVPG TLMIEPTESE 850
PKAELDRFVD AMLNIRREIQ DVQDGTISAA DSPLKHAPHT LKDLMDSEWT 900
RAYSRETGAF PSAAQKAWKY WPAVNRVDNV YGDRNFVCSC PPIEDYIGA 949
Length:949
Mass (Da):102,123
Last modified:May 1, 2000 - v1
Checksum:iFDCBA42D4E0888D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11360.1.
PIRiE75352.
RefSeqiNP_295532.1. NC_001263.1.
WP_010888444.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11360; AAF11360; DR_1809.
GeneIDi1798625.
KEGGidra:DR_1809.
PATRICi21631254. VBIDeiRad64572_2021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11360.1 .
PIRi E75352.
RefSeqi NP_295532.1. NC_001263.1.
WP_010888444.1. NC_001263.1.

3D structure databases

ProteinModelPortali Q9RTF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_1809.

Proteomic databases

PRIDEi Q9RTF5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11360 ; AAF11360 ; DR_1809 .
GeneIDi 1798625.
KEGGi dra:DR_1809.
PATRICi 21631254. VBIDeiRad64572_2021.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-1841-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiGCSP_DEIRA
AccessioniPrimary (citable) accession number: Q9RTF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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