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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:DR_1826
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001897201 – 432Gamma-glutamyl phosphate reductaseAdd BLAST432

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1826

Structurei

3D structure databases

ProteinModelPortaliQ9RTD9
SMRiQ9RTD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S Bacteria
COG0014 LUCA
HOGENOMiHOG000246356
InParanoidiQ9RTD9
KOiK00147
OMAiHGSHHTD
OrthoDBiPOG091H00OT

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RTD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTDSLPGV QATVQDMGER ARRAARVLRS LPTGRKVQAL RALAAELRAR
60 70 80 90 100
EAGILAANAQ DVQAAEAAGL PAPLVDRLRL SAGALAAIAR DVEAVAALPD
110 120 130 140 150
PVGEQTDEKT LPSGIRVSQR RVPLGVLGVI YESRPNVTVD VAALALMSGN
160 170 180 190 200
AAILRGGKET VNSNAALEDA IHAALNREGL PADAVQVIRD PDRARMLELL
210 220 230 240 250
RLDESVDAII PRGGAGLHRF CVENATVPVI VGGIGVVHIY LDGSFVQTPQ
260 270 280 290 300
DVQIAAALIR NAKTQKPSAC NALDTLLIDR AALAALPDVV RPLLESGVEV
310 320 330 340 350
RADAEAQAAL AGAGLNVTSA QLGDYGTEFL ALVASLRTVS GLDEALDFIA
360 370 380 390 400
ERGGHTDVIL TRDPAQAERF VQDVDSAAVM VNVSPRFNDG GQLGLGAEVA
410 420 430
ISTQKLHARG PMGLRELTTS KWVVRGEGQV RD
Length:432
Mass (Da):45,233
Last modified:May 1, 2000 - v1
Checksum:i913FF295EAEAD1DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF11380.1
PIRiD75348
RefSeqiNP_295549.1, NC_001263.1
WP_010888461.1, NZ_CP015081.1

Genome annotation databases

EnsemblBacteriaiAAF11380; AAF11380; DR_1826
GeneIDi1799066
KEGGidra:DR_1826
PATRICifig|243230.17.peg.2038

Similar proteinsi

Entry informationi

Entry nameiPROA_DEIRA
AccessioniPrimary (citable) accession number: Q9RTD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health