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Protein

Glycerol kinase

Gene

glpK

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei18ATPUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei309ATP; via carbonyl oxygenUniRule annotation1
Binding sitei313ATP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 16ATPUniRule annotation3
Nucleotide bindingi410 – 414ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:DR_1928
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000594501 – 501Glycerol kinaseAdd BLAST501

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1928.

Structurei

3D structure databases

ProteinModelPortaliQ9RT38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Substrate bindingUniRule annotation2
Regioni244 – 245Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JQ0. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
InParanoidiQ9RT38.
KOiK00864.
OMAiHTNQWDD.
OrthoDBiPOG091H02FA.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RT38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEHQYILAL DQGTTSSRAI VFDHQGNMKG VGQQEFRQHF PKPGWVEHDA
60 70 80 90 100
NEIWSTQIGV AQQALSNAGI RASDLAAIGI TNQRETTLIW DRATGKPIHH
110 120 130 140 150
AIVWQDRRTA PYCDSIRAQH EKTLQDKTGL VLDAYFSGTK VKWLLDNVPG
160 170 180 190 200
ARERAEKGEL AFGTIDSWLV YNLTGGELHI TDATNASRTL LYNIHTGEWD
210 220 230 240 250
DELLRILDVP RSVLPEVRNS SEVYGKTAAG LLGAQVPIAG IGGDQQAATF
260 270 280 290 300
GQACLERGMA KNTYGTGCFM LMNTEGEAVP SQNKLLTTVA WQLDGERTYA
310 320 330 340 350
LEGSVFIGGA VVQWLRDGLN IIRSSTEIEA LARTVDSSEG VMLVPAFVGL
360 370 380 390 400
GAPYWDAYAR GTMVGITRGT TKAHIARAAL EAVAYQSAEL LEAMQKDSGV
410 420 430 440 450
ELKELRVDGG ASTNDLMMQF QADILGVPVI RPKVTETTAL GAAYLAGLAV
460 470 480 490 500
GYWKSTDDIA HQWQEDKRFE PQMSEEERSK LMRRWKKAVA RARDWEDDSE

A
Length:501
Mass (Da):55,068
Last modified:May 1, 2000 - v1
Checksum:iCAA779EFD2A1EC1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11475.1.
PIRiG75337.
RefSeqiNP_295651.1. NC_001263.1.
WP_010888563.1. NZ_CP015081.1.

Genome annotation databases

EnsemblBacteriaiAAF11475; AAF11475; DR_1928.
GeneIDi1798640.
KEGGidra:DR_1928.
PATRICi21631504. VBIDeiRad64572_2146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11475.1.
PIRiG75337.
RefSeqiNP_295651.1. NC_001263.1.
WP_010888563.1. NZ_CP015081.1.

3D structure databases

ProteinModelPortaliQ9RT38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11475; AAF11475; DR_1928.
GeneIDi1798640.
KEGGidra:DR_1928.
PATRICi21631504. VBIDeiRad64572_2146.

Phylogenomic databases

eggNOGiENOG4108JQ0. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
InParanoidiQ9RT38.
KOiK00864.
OMAiHTNQWDD.
OrthoDBiPOG091H02FA.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK_DEIRA
AccessioniPrimary (citable) accession number: Q9RT38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.