Q9RT38 (GLPK_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	DR_1928

Organism

Deinococcus radiodurans

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Glycerol kinase HAMAP MF_00186		PRO_0000059450
Regions
	Nucleotide binding	410 – 414	5	ATP By similarity
Sites
	Binding site	14	1	Substrate By similarity
	Binding site	18	1	ATP By similarity
	Binding site	84	1	Substrate By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	244	1	Substrate By similarity
	Binding site	266	1	ATP By similarity
	Binding site	309	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RT38 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CAA779EFD2A1EC1F	FASTA	501	55,068
	10 20 30 40 50 60 MSEHQYILAL DQGTTSSRAI VFDHQGNMKG VGQQEFRQHF PKPGWVEHDA NEIWSTQIGV 70 80 90 100 110 120 AQQALSNAGI RASDLAAIGI TNQRETTLIW DRATGKPIHH AIVWQDRRTA PYCDSIRAQH 130 140 150 160 170 180 EKTLQDKTGL VLDAYFSGTK VKWLLDNVPG ARERAEKGEL AFGTIDSWLV YNLTGGELHI 190 200 210 220 230 240 TDATNASRTL LYNIHTGEWD DELLRILDVP RSVLPEVRNS SEVYGKTAAG LLGAQVPIAG 250 260 270 280 290 300 IGGDQQAATF GQACLERGMA KNTYGTGCFM LMNTEGEAVP SQNKLLTTVA WQLDGERTYA 310 320 330 340 350 360 LEGSVFIGGA VVQWLRDGLN IIRSSTEIEA LARTVDSSEG VMLVPAFVGL GAPYWDAYAR 370 380 390 400 410 420 GTMVGITRGT TKAHIARAAL EAVAYQSAEL LEAMQKDSGV ELKELRVDGG ASTNDLMMQF 430 440 450 460 470 480 QADILGVPVI RPKVTETTAL GAAYLAGLAV GYWKSTDDIA HQWQEDKRFE PQMSEEERSK 490 500 LMRRWKKAVA RARDWEDDSE A

References

[1]

"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000513 Genomic DNA. Translation: AAF11475.1.
PIR	G75337.
RefSeq	NP_295651.1. NC_001263.1.
3D structure databases
ProteinModelPortal	Q9RT38.
SMR	Q9RT38. Positions 5-499.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1798640.
GenomeReviews	Gene locus DR_1928 in contig AE000513_GR.
KEGG	dra:DR_1928.
NMPDR	fig|243230.1.peg.2110.
PATRIC	21631504. VBIDeiRad64572_2146.
TIGR	DR_1928.
Phylogenomic databases
HOGENOM	HBG511469.
OMA	ALYGQLC.
PhylomeDB	Q9RT38.
ProtClustDB	CLSK445316.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_1928-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_DEIRA

Accession

Primary (citable) accession number: Q9RT38

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program