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Q9RSY5

- KITH_DEIRA

UniProt

Q9RSY5 - KITH_DEIRA

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Protein

Thymidine kinase

Gene

tdk

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATPUniRule annotation
Nucleotide bindingi99 – 1024ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2018-MONOMER.
BRENDAi2.7.1.21. 1856.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:DR_1984
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Thymidine kinasePRO_0000174970Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_1984.

Structurei

3D structure databases

ProteinModelPortaliQ9RSY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
InParanoidiQ9RSY5.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RSY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSPYSGGH LEVVVGPMFS GKSEELIRRL TRSLIARQRV AVFKPAIDNR
60 70 80 90 100
YHASEVASHA GRTLEAVAVP DAQAIRAQLS GQGELLSAAP EGVDVIGIDE
110 120 130 140 150
AQFFGPELVP LVLELADAGV RVVLAGLDLD FRAEPFGSMP ELLARAESVD
160 170 180 190 200
KLTAICTVCG APATRTQRLI GGQPARFDDP VVLVGAQESY EALPRAPHRA
210
QGGVTTPSPL AS
Length:212
Mass (Da):22,398
Last modified:May 1, 2000 - v1
Checksum:i5ACD76A28C6F88A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11536.1.
PIRiC75330.
RefSeqiNP_295707.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11536; AAF11536; DR_1984.
GeneIDi1800380.
KEGGidra:DR_1984.
PATRICi21631628. VBIDeiRad64572_2207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11536.1 .
PIRi C75330.
RefSeqi NP_295707.1. NC_001263.1.

3D structure databases

ProteinModelPortali Q9RSY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_1984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11536 ; AAF11536 ; DR_1984 .
GeneIDi 1800380.
KEGGi dra:DR_1984.
PATRICi 21631628. VBIDeiRad64572_2207.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
InParanoidi Q9RSY5.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-2018-MONOMER.
BRENDAi 2.7.1.21. 1856.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiKITH_DEIRA
AccessioniPrimary (citable) accession number: Q9RSY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3