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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi490MagnesiumUniRule annotation1
Metal bindingi496MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:DR_2063
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296211 – 779Polyribonucleotide nucleotidyltransferaseAdd BLAST779

Interactioni

Protein-protein interaction databases

DIPiDIP-58603N.
STRINGi243230.DR_2063.

Structurei

3D structure databases

ProteinModelPortaliQ9RSR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini557 – 618KHUniRule annotationAdd BLAST62
Domaini625 – 693S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
InParanoidiQ9RSR1.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RSR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGKTFTTML GGRELSIETG KLAKLVSGSV TVRYGDTLLL VTAQASDTQS
60 70 80 90 100
KLDFLPLTVE FEERHYAVGK IPGSFQRREG RPGEKAILSA RITDRQIRPL
110 120 130 140 150
FPKGYRHETQ VIITVLSADG QNAPDVLGPI GAAAALSISD IPWAGPTACV
160 170 180 190 200
RVGQIDGQYV VNPTTEQLTR SRMDLVVAGT REAVMMVECG AQTVSEDDLV
210 220 230 240 250
GAIEFAHAEM QGVIALIEQM RAEVGHEKFN FLAEEGPAND YVPELTEKAK
260 270 280 290 300
AAGLRDALLT HGKKDRSARL KALRNGLIEG YVPDPTAEGS AELTQALKDA
310 320 330 340 350
FGKVEKRELR RLILEENLRA DGRDSKTVRP IWIEARPLPT AHGSAVFTRG
360 370 380 390 400
ETQVLGVTTL GTERDEILID DLTAESGDKF LLHYNFPPYS TGEVKRMGGQ
410 420 430 440 450
SRREIGHGNL AKRAIRAVLP SFEEFPYVIR VVGDVLESNG SSSMGTVCAG
460 470 480 490 500
TLSLMDAGVP LKAPVAGVAM GLVMEGDNYR VLTDILGLED ALGDMDFKVC
510 520 530 540 550
GTAEGVTALQ MDIKVGGITP QIMREALAQA KEGRLHILGK MAEVLAAPRA
560 570 580 590 600
ELSPTAPHIL SLKINPELIG KVIGPGGKQV RELEAMGAQV TIEEDGTVRI
610 620 630 640 650
FSASGESAEA VKARIEAVTK EAKVGEEFEG TVVKIAPFGA FVNLFPGQDG
660 670 680 690 700
MLHISQLSEQ RVENVEDVLT VGDKLKVKIA NIDDRGKIDL IRPELEGKVP
710 720 730 740 750
LREPRAPRGG DRGPRRDSDR GGDRGPRREF SDRGPRPEGA RSERPEGQRT
760 770
ERPATAPATQ ESSQSSDAPA APVFPRRED
Length:779
Mass (Da):84,062
Last modified:April 29, 2008 - v2
Checksum:iBA5102FE4984A2BB
GO

Sequence cautioni

The sequence AAF11608 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11608.1. Different initiation.
PIRiG75320.
RefSeqiNP_295786.1. NC_001263.1.
WP_010888694.1. NC_001263.1.
WP_027479957.1. NZ_CP015081.1.

Genome annotation databases

EnsemblBacteriaiAAF11608; AAF11608; DR_2063.
GeneIDi1797763.
KEGGidra:DR_2063.
PATRICi21631804. VBIDeiRad64572_2288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11608.1. Different initiation.
PIRiG75320.
RefSeqiNP_295786.1. NC_001263.1.
WP_010888694.1. NC_001263.1.
WP_027479957.1. NZ_CP015081.1.

3D structure databases

ProteinModelPortaliQ9RSR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58603N.
STRINGi243230.DR_2063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11608; AAF11608; DR_2063.
GeneIDi1797763.
KEGGidra:DR_2063.
PATRICi21631804. VBIDeiRad64572_2288.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
InParanoidiQ9RSR1.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_DEIRA
AccessioniPrimary (citable) accession number: Q9RSR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.