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Q9RSL3

- RL6_DEIRA

UniProt

Q9RSL3 - RL6_DEIRA

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Protein

50S ribosomal protein L6

Gene

rplF

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity). This protein binds to the 23S rRNA, and is important in its secondary structure.By similarity

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L6UniRule annotation
Gene namesi
Name:rplFUniRule annotation
Ordered Locus Names:DR_2111
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18518550S ribosomal protein L6PRO_0000131047Add
BLAST

Proteomic databases

PRIDEiQ9RSL3.

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.6 PublicationsUniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_2111.

Structurei

Secondary structure

1
185
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183Combined sources
Beta strandi25 – 273Combined sources
Beta strandi33 – 364Combined sources
Beta strandi39 – 413Combined sources
Beta strandi47 – 515Combined sources
Beta strandi57 – 593Combined sources
Helixi60 – 8122Combined sources
Beta strandi83 – 886Combined sources
Beta strandi89 – 935Combined sources
Beta strandi95 – 995Combined sources
Beta strandi102 – 1065Combined sources
Beta strandi108 – 1114Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi121 – 1244Combined sources
Beta strandi130 – 1378Combined sources
Helixi138 – 14811Combined sources
Turni149 – 1524Combined sources
Turni156 – 1583Combined sources
Beta strandi161 – 1633Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKWX-ray3.10E1-185[»]
1NWXX-ray3.50E1-185[»]
1NWYX-ray3.30E1-185[»]
1PNUX-ray8.70E5-181[»]
1PNYX-ray9.50E5-181[»]
1SM1X-ray3.42E1-185[»]
1VORX-ray11.50H5-181[»]
1VOYX-ray11.50H5-181[»]
1VP0X-ray11.50H5-181[»]
1XBPX-ray3.50E1-185[»]
2ZJPX-ray3.70E1-185[»]
2ZJQX-ray3.30E1-185[»]
2ZJRX-ray2.91E1-185[»]
3CF5X-ray3.30E1-185[»]
3DLLX-ray3.50E1-185[»]
3PIOX-ray3.25E1-185[»]
3PIPX-ray3.45E1-185[»]
4IO9X-ray3.20E1-185[»]
4IOAX-ray3.20E1-185[»]
4IOCX-ray3.60E1-185[»]
ProteinModelPortaliQ9RSL3.
SMRiQ9RSL3. Positions 5-181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RSL3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0097.
HOGENOMiHOG000039903.
InParanoidiQ9RSL3.
KOiK02933.
OMAiAANKNAR.
OrthoDBiEOG67DPRD.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
HAMAPiMF_01365_B. Ribosomal_L6_B.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSiPR00059. RIBOSOMALL6.
SUPFAMiSSF56053. SSF56053. 2 hits.
TIGRFAMsiTIGR03654. L6_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RSL3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRIGKQPIA VPSGVTVNAQ DGVFKVKGPK GELTVPYNTE LTVRQDGDQL
60 70 80 90 100
LVERPSDAQK HRALHGLTRT LVANAVKGVS DGYTINLELR GVGFRAKLTG
110 120 130 140 150
KALEMNIGYS HPVIIEPPAG VTFAVPEPTR IDVSGIDKQL VGQVAANVRK
160 170 180
VRKPDAYHGK GVRFVGEQIA LKAGKAGATG GKGKK
Length:185
Mass (Da):19,582
Last modified:March 15, 2004 - v2
Checksum:i00E39D11826B4C1D
GO

Sequence cautioni

The sequence AAF11660.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11660.1. Different initiation.
PIRiB75314.
RefSeqiNP_295834.2. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11660; AAF11660; DR_2111.
GeneIDi1800121.
KEGGidra:DR_2111.
PATRICi21631898. VBIDeiRad64572_2334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11660.1 . Different initiation.
PIRi B75314.
RefSeqi NP_295834.2. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NKW X-ray 3.10 E 1-185 [» ]
1NWX X-ray 3.50 E 1-185 [» ]
1NWY X-ray 3.30 E 1-185 [» ]
1PNU X-ray 8.70 E 5-181 [» ]
1PNY X-ray 9.50 E 5-181 [» ]
1SM1 X-ray 3.42 E 1-185 [» ]
1VOR X-ray 11.50 H 5-181 [» ]
1VOY X-ray 11.50 H 5-181 [» ]
1VP0 X-ray 11.50 H 5-181 [» ]
1XBP X-ray 3.50 E 1-185 [» ]
2ZJP X-ray 3.70 E 1-185 [» ]
2ZJQ X-ray 3.30 E 1-185 [» ]
2ZJR X-ray 2.91 E 1-185 [» ]
3CF5 X-ray 3.30 E 1-185 [» ]
3DLL X-ray 3.50 E 1-185 [» ]
3PIO X-ray 3.25 E 1-185 [» ]
3PIP X-ray 3.45 E 1-185 [» ]
4IO9 X-ray 3.20 E 1-185 [» ]
4IOA X-ray 3.20 E 1-185 [» ]
4IOC X-ray 3.60 E 1-185 [» ]
ProteinModelPortali Q9RSL3.
SMRi Q9RSL3. Positions 5-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_2111.

Proteomic databases

PRIDEi Q9RSL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11660 ; AAF11660 ; DR_2111 .
GeneIDi 1800121.
KEGGi dra:DR_2111.
PATRICi 21631898. VBIDeiRad64572_2334.

Phylogenomic databases

eggNOGi COG0097.
HOGENOMi HOG000039903.
InParanoidi Q9RSL3.
KOi K02933.
OMAi AANKNAR.
OrthoDBi EOG67DPRD.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-2154-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9RSL3.

Family and domain databases

Gene3Di 3.90.930.12. 2 hits.
HAMAPi MF_01365_B. Ribosomal_L6_B.
InterProi IPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
[Graphical view ]
PANTHERi PTHR11655. PTHR11655. 1 hit.
Pfami PF00347. Ribosomal_L6. 2 hits.
[Graphical view ]
PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
PRINTSi PR00059. RIBOSOMALL6.
SUPFAMi SSF56053. SSF56053. 2 hits.
TIGRFAMsi TIGR03654. L6_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
    Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
    Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, PROTEIN SEQUENCE OF 1-5.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
    Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
    Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
    Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
    Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  5. "Structural basis for the antibiotic activity of ketolides and azalides."
    Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
    Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
    Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
    Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
    Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
    BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
    Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
    Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiRL6_DEIRA
AccessioniPrimary (citable) accession number: Q9RSL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3