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Q9RSL3

- RL6_DEIRA

UniProt

Q9RSL3 - RL6_DEIRA

Protein

50S ribosomal protein L6

Gene

rplF

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. This protein binds to the 23S rRNA, and is important in its secondary structure.By similarity

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-2154-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L6UniRule annotation
    Gene namesi
    Name:rplFUniRule annotation
    Ordered Locus Names:DR_2111
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18518550S ribosomal protein L6PRO_0000131047Add
    BLAST

    Proteomic databases

    PRIDEiQ9RSL3.

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit.6 PublicationsUniRule annotation

    Protein-protein interaction databases

    STRINGi243230.DR_2111.

    Structurei

    Secondary structure

    1
    185
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 183
    Beta strandi25 – 273
    Beta strandi33 – 364
    Beta strandi39 – 413
    Beta strandi47 – 515
    Beta strandi57 – 593
    Helixi60 – 8122
    Beta strandi83 – 886
    Beta strandi89 – 935
    Beta strandi95 – 995
    Beta strandi102 – 1065
    Beta strandi108 – 1114
    Beta strandi113 – 1153
    Beta strandi121 – 1244
    Beta strandi130 – 1378
    Helixi138 – 14811
    Turni149 – 1524
    Turni156 – 1583
    Beta strandi161 – 1633

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NKWX-ray3.10E1-185[»]
    1NWXX-ray3.50E1-185[»]
    1NWYX-ray3.30E1-185[»]
    1PNUX-ray8.70E5-181[»]
    1PNYX-ray9.50E5-181[»]
    1SM1X-ray3.42E1-185[»]
    1VORX-ray11.50H5-181[»]
    1VOYX-ray11.50H5-181[»]
    1VP0X-ray11.50H5-181[»]
    1XBPX-ray3.50E1-185[»]
    2ZJPX-ray3.70E1-185[»]
    2ZJQX-ray3.30E1-185[»]
    2ZJRX-ray2.91E1-185[»]
    3CF5X-ray3.30E1-185[»]
    3DLLX-ray3.50E1-185[»]
    3PIOX-ray3.25E1-185[»]
    3PIPX-ray3.45E1-185[»]
    4IO9X-ray3.20E1-185[»]
    4IOAX-ray3.20E1-185[»]
    4IOCX-ray3.60E1-185[»]
    ProteinModelPortaliQ9RSL3.
    SMRiQ9RSL3. Positions 5-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9RSL3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L6P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0097.
    HOGENOMiHOG000039903.
    KOiK02933.
    OMAiAANKNAR.
    OrthoDBiEOG67DPRD.

    Family and domain databases

    Gene3Di3.90.930.12. 2 hits.
    HAMAPiMF_01365_B. Ribosomal_L6_B.
    InterProiIPR000702. Ribosomal_L6.
    IPR020040. Ribosomal_L6_a/b-dom.
    IPR019906. Ribosomal_L6_bac-type.
    [Graphical view]
    PANTHERiPTHR11655. PTHR11655. 1 hit.
    PfamiPF00347. Ribosomal_L6. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
    PRINTSiPR00059. RIBOSOMALL6.
    SUPFAMiSSF56053. SSF56053. 2 hits.
    TIGRFAMsiTIGR03654. L6_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RSL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRIGKQPIA VPSGVTVNAQ DGVFKVKGPK GELTVPYNTE LTVRQDGDQL    50
    LVERPSDAQK HRALHGLTRT LVANAVKGVS DGYTINLELR GVGFRAKLTG 100
    KALEMNIGYS HPVIIEPPAG VTFAVPEPTR IDVSGIDKQL VGQVAANVRK 150
    VRKPDAYHGK GVRFVGEQIA LKAGKAGATG GKGKK 185
    Length:185
    Mass (Da):19,582
    Last modified:March 15, 2004 - v2
    Checksum:i00E39D11826B4C1D
    GO

    Sequence cautioni

    The sequence AAF11660.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11660.1. Different initiation.
    PIRiB75314.
    RefSeqiNP_295834.2. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11660; AAF11660; DR_2111.
    GeneIDi1800121.
    KEGGidra:DR_2111.
    PATRICi21631898. VBIDeiRad64572_2334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11660.1 . Different initiation.
    PIRi B75314.
    RefSeqi NP_295834.2. NC_001263.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NKW X-ray 3.10 E 1-185 [» ]
    1NWX X-ray 3.50 E 1-185 [» ]
    1NWY X-ray 3.30 E 1-185 [» ]
    1PNU X-ray 8.70 E 5-181 [» ]
    1PNY X-ray 9.50 E 5-181 [» ]
    1SM1 X-ray 3.42 E 1-185 [» ]
    1VOR X-ray 11.50 H 5-181 [» ]
    1VOY X-ray 11.50 H 5-181 [» ]
    1VP0 X-ray 11.50 H 5-181 [» ]
    1XBP X-ray 3.50 E 1-185 [» ]
    2ZJP X-ray 3.70 E 1-185 [» ]
    2ZJQ X-ray 3.30 E 1-185 [» ]
    2ZJR X-ray 2.91 E 1-185 [» ]
    3CF5 X-ray 3.30 E 1-185 [» ]
    3DLL X-ray 3.50 E 1-185 [» ]
    3PIO X-ray 3.25 E 1-185 [» ]
    3PIP X-ray 3.45 E 1-185 [» ]
    4IO9 X-ray 3.20 E 1-185 [» ]
    4IOA X-ray 3.20 E 1-185 [» ]
    4IOC X-ray 3.60 E 1-185 [» ]
    ProteinModelPortali Q9RSL3.
    SMRi Q9RSL3. Positions 5-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_2111.

    Proteomic databases

    PRIDEi Q9RSL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11660 ; AAF11660 ; DR_2111 .
    GeneIDi 1800121.
    KEGGi dra:DR_2111.
    PATRICi 21631898. VBIDeiRad64572_2334.

    Phylogenomic databases

    eggNOGi COG0097.
    HOGENOMi HOG000039903.
    KOi K02933.
    OMAi AANKNAR.
    OrthoDBi EOG67DPRD.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-2154-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9RSL3.

    Family and domain databases

    Gene3Di 3.90.930.12. 2 hits.
    HAMAPi MF_01365_B. Ribosomal_L6_B.
    InterProi IPR000702. Ribosomal_L6.
    IPR020040. Ribosomal_L6_a/b-dom.
    IPR019906. Ribosomal_L6_bac-type.
    [Graphical view ]
    PANTHERi PTHR11655. PTHR11655. 1 hit.
    Pfami PF00347. Ribosomal_L6. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
    PRINTSi PR00059. RIBOSOMALL6.
    SUPFAMi SSF56053. SSF56053. 2 hits.
    TIGRFAMsi TIGR03654. L6_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
      Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
      Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, PROTEIN SEQUENCE OF 1-5.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
      Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
      Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
      Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
      Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    5. "Structural basis for the antibiotic activity of ketolides and azalides."
      Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
      Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
      Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
      Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
      Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
      BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
      Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
      Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiRL6_DEIRA
    AccessioniPrimary (citable) accession number: Q9RSL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3