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Q9RSL3

- RL6_DEIRA

UniProt

Q9RSL3 - RL6_DEIRA

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Protein
50S ribosomal protein L6
Gene
rplF, DR_2111
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. This protein binds to the 23S rRNA, and is important in its secondary structure.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L6
Gene namesi
Name:rplF
Ordered Locus Names:DR_2111
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18518550S ribosomal protein L6UniRule annotation
PRO_0000131047Add
BLAST

Proteomic databases

PRIDEiQ9RSL3.

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.7 Publications

Protein-protein interaction databases

STRINGi243230.DR_2111.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183
Beta strandi25 – 273
Beta strandi33 – 364
Beta strandi39 – 413
Beta strandi47 – 515
Beta strandi57 – 593
Helixi60 – 8122
Beta strandi83 – 886
Beta strandi89 – 935
Beta strandi95 – 995
Beta strandi102 – 1065
Beta strandi108 – 1114
Beta strandi113 – 1153
Beta strandi121 – 1244
Beta strandi130 – 1378
Helixi138 – 14811
Turni149 – 1524
Turni156 – 1583
Beta strandi161 – 1633

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKWX-ray3.10E1-185[»]
1NWXX-ray3.50E1-185[»]
1NWYX-ray3.30E1-185[»]
1PNUX-ray8.70E5-181[»]
1PNYX-ray9.50E5-181[»]
1SM1X-ray3.42E1-185[»]
1VORX-ray11.50H5-181[»]
1VOYX-ray11.50H5-181[»]
1VP0X-ray11.50H5-181[»]
1XBPX-ray3.50E1-185[»]
2ZJPX-ray3.70E1-185[»]
2ZJQX-ray3.30E1-185[»]
2ZJRX-ray2.91E1-185[»]
3CF5X-ray3.30E1-185[»]
3DLLX-ray3.50E1-185[»]
3PIOX-ray3.25E1-185[»]
3PIPX-ray3.45E1-185[»]
4IO9X-ray3.20E1-185[»]
4IOAX-ray3.20E1-185[»]
4IOCX-ray3.60E1-185[»]
ProteinModelPortaliQ9RSL3.
SMRiQ9RSL3. Positions 5-181.

Miscellaneous databases

EvolutionaryTraceiQ9RSL3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0097.
HOGENOMiHOG000039903.
KOiK02933.
OMAiAANKNAR.
OrthoDBiEOG67DPRD.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
HAMAPiMF_01365_B. Ribosomal_L6_B.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSiPR00059. RIBOSOMALL6.
SUPFAMiSSF56053. SSF56053. 2 hits.
TIGRFAMsiTIGR03654. L6_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RSL3-1 [UniParc]FASTAAdd to Basket

« Hide

MSRIGKQPIA VPSGVTVNAQ DGVFKVKGPK GELTVPYNTE LTVRQDGDQL    50
LVERPSDAQK HRALHGLTRT LVANAVKGVS DGYTINLELR GVGFRAKLTG 100
KALEMNIGYS HPVIIEPPAG VTFAVPEPTR IDVSGIDKQL VGQVAANVRK 150
VRKPDAYHGK GVRFVGEQIA LKAGKAGATG GKGKK 185
Length:185
Mass (Da):19,582
Last modified:March 15, 2004 - v2
Checksum:i00E39D11826B4C1D
GO

Sequence cautioni

The sequence AAF11660.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11660.1. Different initiation.
PIRiB75314.
RefSeqiNP_295834.2. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11660; AAF11660; DR_2111.
GeneIDi1800121.
KEGGidra:DR_2111.
PATRICi21631898. VBIDeiRad64572_2334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11660.1 . Different initiation.
PIRi B75314.
RefSeqi NP_295834.2. NC_001263.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NKW X-ray 3.10 E 1-185 [» ]
1NWX X-ray 3.50 E 1-185 [» ]
1NWY X-ray 3.30 E 1-185 [» ]
1PNU X-ray 8.70 E 5-181 [» ]
1PNY X-ray 9.50 E 5-181 [» ]
1SM1 X-ray 3.42 E 1-185 [» ]
1VOR X-ray 11.50 H 5-181 [» ]
1VOY X-ray 11.50 H 5-181 [» ]
1VP0 X-ray 11.50 H 5-181 [» ]
1XBP X-ray 3.50 E 1-185 [» ]
2ZJP X-ray 3.70 E 1-185 [» ]
2ZJQ X-ray 3.30 E 1-185 [» ]
2ZJR X-ray 2.91 E 1-185 [» ]
3CF5 X-ray 3.30 E 1-185 [» ]
3DLL X-ray 3.50 E 1-185 [» ]
3PIO X-ray 3.25 E 1-185 [» ]
3PIP X-ray 3.45 E 1-185 [» ]
4IO9 X-ray 3.20 E 1-185 [» ]
4IOA X-ray 3.20 E 1-185 [» ]
4IOC X-ray 3.60 E 1-185 [» ]
ProteinModelPortali Q9RSL3.
SMRi Q9RSL3. Positions 5-181.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243230.DR_2111.

Proteomic databases

PRIDEi Q9RSL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11660 ; AAF11660 ; DR_2111 .
GeneIDi 1800121.
KEGGi dra:DR_2111.
PATRICi 21631898. VBIDeiRad64572_2334.

Phylogenomic databases

eggNOGi COG0097.
HOGENOMi HOG000039903.
KOi K02933.
OMAi AANKNAR.
OrthoDBi EOG67DPRD.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-2154-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9RSL3.

Family and domain databases

Gene3Di 3.90.930.12. 2 hits.
HAMAPi MF_01365_B. Ribosomal_L6_B.
InterProi IPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
[Graphical view ]
PANTHERi PTHR11655. PTHR11655. 1 hit.
Pfami PF00347. Ribosomal_L6. 2 hits.
[Graphical view ]
PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
PRINTSi PR00059. RIBOSOMALL6.
SUPFAMi SSF56053. SSF56053. 2 hits.
TIGRFAMsi TIGR03654. L6_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
    Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
    Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, PROTEIN SEQUENCE OF 1-5.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
    Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
    Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
    Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
    Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  5. "Structural basis for the antibiotic activity of ketolides and azalides."
    Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
    Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
    Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
    Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
    Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
    BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
    Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
    Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiRL6_DEIRA
AccessioniPrimary (citable) accession number: Q9RSL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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