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Q9RSI4

- HISX_DEIRA

UniProt

Q9RSI4 - HISX_DEIRA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351NADUniRule annotation
Binding sitei197 – 1971NADUniRule annotation
Binding sitei220 – 2201NADUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Metal bindingi268 – 2681ZincUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation
Active sitei334 – 3341Proton acceptorUniRule annotation
Active sitei335 – 3351Proton acceptorUniRule annotation
Binding sitei335 – 3351SubstrateUniRule annotation
Metal bindingi368 – 3681ZincUniRule annotation
Binding sitei368 – 3681SubstrateUniRule annotation
Binding sitei422 – 4221SubstrateUniRule annotation
Metal bindingi427 – 4271ZincUniRule annotation
Binding sitei427 – 4271SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2183-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:DR_2140
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenasePRO_0000135766Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_2140.

Structurei

3D structure databases

ProteinModelPortaliQ9RSI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ9RSI4.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RSI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVLQGAEAR AALTRTFSQI PVPDAVLSRI EQTFGERLTP EQVVERILLD
60 70 80 90 100
VRARGDDALR DWTERLDGPR PAELEVPAAE LEAAQVAPEL HAAIRLAAER
110 120 130 140 150
VRAFYRQQPA HGFLEHGPDG ALGQLVRPLG RVGVYVPGGL APLISTLMHT
160 170 180 190 200
AVPAQVAGVP DIVVTTPPGK DGQVHPAILV AARELGLSRV FKVGGAQAIA
210 220 230 240 250
ALAYGTASVP AVDKIAGPGN LFVVIAKRLV YGQTGIESLP GPTETLVVAD
260 270 280 290 300
DSASPRYVAA DLLAQAEHNG AEPVLVSVSR ELLLAVQAEL NEQLENLPEP
310 320 330 340 350
NRSWARDSVG ARMKVVLADS LDEALDLANL YAPEHLCLLT RDPWSLLGQV
360 370 380 390 400
RRAGGVFVGE ASMEALGDYV AGPSHVMPTG GTARFMSPVN VRDFQNIISV
410 420 430
VGVNEETLRR IGPAAATLAR AEGLEAHARA VESRLK
Length:436
Mass (Da):46,273
Last modified:May 1, 2000 - v1
Checksum:iFB3A68DF7457E6B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11684.1.
PIRiA75311.
RefSeqiNP_295863.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11684; AAF11684; DR_2140.
GeneIDi1800305.
KEGGidra:DR_2140.
PATRICi21631956. VBIDeiRad64572_2363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11684.1 .
PIRi A75311.
RefSeqi NP_295863.1. NC_001263.1.

3D structure databases

ProteinModelPortali Q9RSI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_2140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11684 ; AAF11684 ; DR_2140 .
GeneIDi 1800305.
KEGGi dra:DR_2140.
PATRICi 21631956. VBIDeiRad64572_2363.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
InParanoidi Q9RSI4.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci DRAD243230:GH46-2183-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiHISX_DEIRA
AccessioniPrimary (citable) accession number: Q9RSI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3