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Q9RSF0

- SYL_DEIRA

UniProt

Q9RSF0 - SYL_DEIRA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei593 – 5931ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-2217-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:DR_2174
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 823823Leucine--tRNA ligasePRO_0000152009Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243230.DR_2174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RSF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi55 – 6511"HIGH" regionAdd
    BLAST
    Motifi590 – 5945"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RSF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQEATKPNI QEPRAERYNP HAIEQKWQGQ WQESGLYKFD ENAPGEKFYA    50
    LTMFPYPSGN LHIGHWYANV APDARARWLR MRGYNVLFPM AFDAFGLPAE 100
    NAAIKNNTNP ATWTYANIER MTGQFSRMGT MIDWSRKFAT CDPEYYRWNQ 150
    WFFIEFWKRG LAYKKGGLVN WCPKDQTVLA NEQVVNGHCE RCGTAVERRN 200
    LSQWYLKITD YAEELLDFSA TDMPEKVRAM QTNWIGKSVG AEVTFDTPAG 250
    PETVFTTRPD TLMGATFMVL APEHAKVKEL TTDEQRAEVE AYVAAAGRKT 300
    DVERQQEGEK TGVFTGSYAT HPISGHQLPI WVADYVLVTY GTGSIMAVPA 350
    HDERDFAFAK KFDLPIREVI RAEGSEGMGD QPSEPYSGEG QIVNSGEFDG 400
    MPGGKASIAA IIARLEERGV AKAKTTYRLR DWLFARQRYW GTPIPFVHCE 450
    KCGMQPVPED QLPVKLPENV AFTPTGQSPL KLDEEWKTTT CPCCGGPAER 500
    ETDTMDTFVD SSWYMYRYLS PNYDGGPFDP SKAGLLPVDL YTGGIEHAIL 550
    HLLYSRFWTK VMRDMGLTTQ SEPFARLRNQ GMVLGEDGEK MSKSRGNVVD 600
    PDDLVREYGA DTVRAFLMFI APWELGGPWD PQGINGPSKW LSRVWNVFFE 650
    EKVSGPEEKM QGADVRFAVH SALKKVNDDF ERMSFNTIIS TLMELTNALV 700
    KAKRSPVFGT PVWEEALDIF NRMLAPVVPH IAEEIWHERG QKGSVHTAQW 750
    PQVDEAAAVR DTVTIGVQVS GKVRGEVSIS KTASQEEALS AARAIAEVQK 800
    HLEGKTVVKE IYVPGRIINI VAK 823
    Length:823
    Mass (Da):92,613
    Last modified:June 1, 2001 - v2
    Checksum:i2E6445F39005A110
    GO

    Sequence cautioni

    The sequence AAF11720.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11720.1. Different initiation.
    PIRiD75307.
    RefSeqiNP_295897.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11720; AAF11720; DR_2174.
    GeneIDi1799430.
    KEGGidra:DR_2174.
    PATRICi21632026. VBIDeiRad64572_2398.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11720.1 . Different initiation.
    PIRi D75307.
    RefSeqi NP_295897.1. NC_001263.1.

    3D structure databases

    ProteinModelPortali Q9RSF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_2174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11720 ; AAF11720 ; DR_2174 .
    GeneIDi 1799430.
    KEGGi dra:DR_2174.
    PATRICi 21632026. VBIDeiRad64572_2398.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-2217-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiSYL_DEIRA
    AccessioniPrimary (citable) accession number: Q9RSF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3