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Q9RSF0

- SYL_DEIRA

UniProt

Q9RSF0 - SYL_DEIRA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei593 – 5931ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DR_2174
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 823823Leucine--tRNA ligasePRO_0000152009Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_2174.

Structurei

3D structure databases

ProteinModelPortaliQ9RSF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6511"HIGH" regionAdd
BLAST
Motifi590 – 5945"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
InParanoidiQ9RSF0.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RSF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQEATKPNI QEPRAERYNP HAIEQKWQGQ WQESGLYKFD ENAPGEKFYA
60 70 80 90 100
LTMFPYPSGN LHIGHWYANV APDARARWLR MRGYNVLFPM AFDAFGLPAE
110 120 130 140 150
NAAIKNNTNP ATWTYANIER MTGQFSRMGT MIDWSRKFAT CDPEYYRWNQ
160 170 180 190 200
WFFIEFWKRG LAYKKGGLVN WCPKDQTVLA NEQVVNGHCE RCGTAVERRN
210 220 230 240 250
LSQWYLKITD YAEELLDFSA TDMPEKVRAM QTNWIGKSVG AEVTFDTPAG
260 270 280 290 300
PETVFTTRPD TLMGATFMVL APEHAKVKEL TTDEQRAEVE AYVAAAGRKT
310 320 330 340 350
DVERQQEGEK TGVFTGSYAT HPISGHQLPI WVADYVLVTY GTGSIMAVPA
360 370 380 390 400
HDERDFAFAK KFDLPIREVI RAEGSEGMGD QPSEPYSGEG QIVNSGEFDG
410 420 430 440 450
MPGGKASIAA IIARLEERGV AKAKTTYRLR DWLFARQRYW GTPIPFVHCE
460 470 480 490 500
KCGMQPVPED QLPVKLPENV AFTPTGQSPL KLDEEWKTTT CPCCGGPAER
510 520 530 540 550
ETDTMDTFVD SSWYMYRYLS PNYDGGPFDP SKAGLLPVDL YTGGIEHAIL
560 570 580 590 600
HLLYSRFWTK VMRDMGLTTQ SEPFARLRNQ GMVLGEDGEK MSKSRGNVVD
610 620 630 640 650
PDDLVREYGA DTVRAFLMFI APWELGGPWD PQGINGPSKW LSRVWNVFFE
660 670 680 690 700
EKVSGPEEKM QGADVRFAVH SALKKVNDDF ERMSFNTIIS TLMELTNALV
710 720 730 740 750
KAKRSPVFGT PVWEEALDIF NRMLAPVVPH IAEEIWHERG QKGSVHTAQW
760 770 780 790 800
PQVDEAAAVR DTVTIGVQVS GKVRGEVSIS KTASQEEALS AARAIAEVQK
810 820
HLEGKTVVKE IYVPGRIINI VAK
Length:823
Mass (Da):92,613
Last modified:June 1, 2001 - v2
Checksum:i2E6445F39005A110
GO

Sequence cautioni

The sequence AAF11720.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11720.1. Different initiation.
PIRiD75307.
RefSeqiNP_295897.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11720; AAF11720; DR_2174.
GeneIDi1799430.
KEGGidra:DR_2174.
PATRICi21632026. VBIDeiRad64572_2398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11720.1 . Different initiation.
PIRi D75307.
RefSeqi NP_295897.1. NC_001263.1.

3D structure databases

ProteinModelPortali Q9RSF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_2174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11720 ; AAF11720 ; DR_2174 .
GeneIDi 1799430.
KEGGi dra:DR_2174.
PATRICi 21632026. VBIDeiRad64572_2398.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
InParanoidi Q9RSF0.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-2217-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiSYL_DEIRA
AccessioniPrimary (citable) accession number: Q9RSF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3