Reviewed, UniProtKB/Swiss-Prot Q9RS38 (KGUA_DEIRA)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	DR_2289

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Guanylate kinase HAMAP MF_00328		PRO_0000170531
Regions
	Domain	19 – 197	179	Guanylate kinase-like
	Nucleotide binding	26 – 33	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RS38-1 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 930AE5040D622722	FASTA	239	26,528
	10 20 30 40 50 60 MMASAPQDRP AGTPPQGRGL LIVVTGASGV GKGTLRERWL AGQDVFYSTS WTTREPRPGE 70 80 90 100 110 120 VNGRDYVFVS PAEFLAKAQQ NGFLEHAQFV GNHYGTPIEP IEAALERGQD VVLEIEVEGA 130 140 150 160 170 180 MQVKDRMGEQ AILVFIMPPS LTELRRRLTG RATETPERIE KRLTRARDEI QAAHDFRYVI 190 200 210 220 230 VNDNLDRAVS ELLAVQQAER AAQKAAEHWT PEEQQARALA DTVRSTALSR EALQQVVES

References

[1]

"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000513 Genomic DNA. Translation: AAF11836.1. Different initiation.
PIR	C75291.
RefSeq	NP_296010.1.
3D structure databases
HSSP	HSSP built from PDB template 1GKY based on UniProtKB P15454.
ModBase	Search...
Genome annotation databases
GeneID	1798710.
GenomeReviews	Gene locus DR_2289 in contig AE000513_GR.
KEGG	dra:DR_2289.
NMPDR	fig|243230.1.peg.2469.
TIGR	DR_2289.
Phylogenomic databases
HOGENOM	Q9RS38.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_2289-MON.
BRENDA	2.7.4.8. 96172.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_DEIRA

Accession

Primary (citable) accession number: Q9RS38

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	September 22, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)