Q9RRT8 (SURE_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	DR_2397

Organism

Deinococcus radiodurans

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	5'-nucleotidase surE HAMAP MF_00060		PRO_0000111808
Sites
	Metal binding	24	1	Divalent metal cation By similarity
	Metal binding	25	1	Divalent metal cation By similarity
	Metal binding	55	1	Divalent metal cation By similarity
	Metal binding	111	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RRT8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: AA9C524EA5F49072	FASTA	268	28,297
	10 20 30 40 50 60 MTVPDPARPA ASPSARPRVL VANDDGIFAP GIKALGLALS EWADVVVVAP DVEQSAVGHG 70 80 90 100 110 120 ITIRRPLRFK HTAAAGFGDI PAYRVDGTPA DCVVLGVHLL GRPDLVVSGI NIGPNLGEDL 130 140 150 160 170 180 THSGTVAAAI EGLTLGLPSI AFSQFANEAG EYDFGPSAAY ASRLAREVCC RGLPPRVLLN 190 200 210 220 230 240 VNFPRVSPRG VRVTEVGLHR WEDSVVTRQD PEGRDYHWVA GVSTAHDGHD EQTDYGAVQA 250 260 GFISVSPVRL DLTARDLIGE LTQALPPL

References

[1]

"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000513 Genomic DNA. Translation: AAF11943.1.
PIR	B75279.
RefSeq	NP_296118.1. NC_001263.1.
3D structure databases
ProteinModelPortal	Q9RRT8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1797491.
GenomeReviews	Gene locus DR_2397 in contig AE000513_GR.
KEGG	dra:DR_2397.
NMPDR	fig|243230.1.peg.2577.
PATRIC	21632512. VBIDeiRad64572_2633.
TIGR	DR_2397.
Phylogenomic databases
HOGENOM	HBG600532.
OMA	NGFYYVN.
PhylomeDB	Q9RRT8.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_2397-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_DEIRA

Accession

Primary (citable) accession number: Q9RRT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program