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Q9RR89 (ISPE_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Short name=CMK
EC=2.7.1.148
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene names
Name:ispE
Ordered Locus Names:DR_2605
OrganismDeinococcus radiodurans
Taxonomic identifier1299 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2992994-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
PRO_0000189213

Regions

Nucleotide binding99 – 10911ATP Potential

Sites

Active site171 By similarity
Active site1421 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RR89 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 215CE4CE68D49DC6

FASTA29930,919
        10         20         30         40         50         60 
MTHQPSPVIH HHFAPAKINL GLSVLGVREN GYHDLHSLMV PLTVGDELEI RPAGALTLRV 

        70         80         90        100        110        120 
EGADLPTDER NLVYRAARAY LDAAGAAGGA DLVLHKRLPL ASGLGGGSSD AASTLLALAE 

       130        140        150        160        170        180 
LYPAPDHRPV DLPALALTLG ADVPFFLLGG AALAEGVGER LTPVDDLPPV HLVLANAGAE 

       190        200        210        220        230        240 
VSAGDAYRWL DETGDFSGKL RLEAMRLALA RGVEVPYFNS LQAGVLARVP SVLTTLEALA 

       250        260        270        280        290 
DAGLHSVLMS GSGATCFGLA HDAAQAQAAA AALAQRCPGW WVTAAQVRLP LSDNSGGRT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000513 Genomic DNA. Translation: AAF12142.1.
PIRE75254.
RefSeqNP_296324.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RR89.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1800267.
GenomeReviewsGene locus DR_2605 in contig AE000513_GR.
KEGGdra:DR_2605.
NMPDRfig|243230.1.peg.2783.
PATRIC21632963. VBIDeiRad64572_2852.
TIGRDR_2605.

Phylogenomic databases

HOGENOMHBG734593.
OMAKINLHLG.
PhylomeDBQ9RR89.
ProtClustDBPRK14612.

Enzyme and pathway databases

BioCycDRAD243230:DR_2605-MONOMER.

Family and domain databases

HAMAPMF_00061. IspE.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00919.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. IspE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPE_DEIRA
AccessionPrimary (citable) accession number: Q9RR89
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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