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Protein

Sensor protein DivL

Gene

divL

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC3484-MONOMER.
BRENDAi2.7.13.3. 1218.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein DivL (EC:2.7.13.3)
Gene namesi
Name:divL
Ordered Locus Names:CC_3484
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769Sensor protein DivLPRO_0000074729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei550 – 5501Phosphotyrosine; by autocatalysis1 Publication

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiQ9RQQ9.

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_3484.

Structurei

Secondary structure

1
769
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi527 – 56741Combined sources
Helixi574 – 60431Combined sources
Beta strandi613 – 6164Combined sources
Helixi617 – 63418Combined sources
Beta strandi638 – 6425Combined sources
Helixi645 – 6473Combined sources
Beta strandi649 – 6524Combined sources
Helixi654 – 67118Combined sources
Beta strandi677 – 6848Combined sources
Beta strandi686 – 69712Combined sources
Helixi702 – 7054Combined sources
Turni706 – 7094Combined sources
Helixi723 – 73311Combined sources
Beta strandi737 – 7426Combined sources
Beta strandi748 – 7558Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q20X-ray2.50A/B523-769[»]
ProteinModelPortaliQ9RQQ9.
SMRiQ9RQQ9. Positions 526-758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini547 – 758212Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 221213Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105I8F. Bacteria.
ENOG410Y097. LUCA.
HOGENOMiHOG000226687.
KOiK00936.
OMAiLKNDFVQ.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RQQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYDLILAA AAGAVCLAIS VALWSHGQRR NLEARIVALK TRLIQQGGSD
60 70 80 90 100
DAPAWLDAFD TAVIAVEGGR ANLVAGGEGL IACAKALGAD AEVSAVVAAL
110 120 130 140 150
SDADPNYAQK LTALFERGEP CVFEARGPHG LVSVEGRAAG ALAWLRLAPI
160 170 180 190 200
DRADSGLPTA ARFAAFVDSV VEPCWIAGAD GQAIWGNAAF VRAVGAASAQ
210 220 230 240 250
APALAGKSFD RGADAVVVEA AGKGERREAL RWINVEGRRR AFRLSAQPLD
260 270 280 290 300
GGGVGVFCAD VTEIEDVRDA FKKHVEAHDE TLNHIAEAVA IFSQTRRLSY
310 320 330 340 350
HNTAFAELWG LEPAWLADRP THGEVLDRLR QRRRLPETID YAGWKAAELA
360 370 380 390 400
RYEDLGPQAD DLWDLPDGRT LKVVRQPHPL GGMLLIYSDI TGELRLKAQY
410 420 430 440 450
NALIQVQQAT LDKLNDAVAV FGSDGRLRLH NEAFETFWNV TPHALEAAGD
460 470 480 490 500
FEGVVELCVP RLHDLSFWRE LKGRVADPDP QMRAPTSGEV RTSDSRIVLY
510 520 530 540 550
QSRPLPDGAT LIAFADVTDT RDLQSALADR SAALAEAERL KRDFVGNVSY
560 570 580 590 600
ELRTPLTTII GYSELLERAD GISERGRNHV AAVRAAATQL ARSIDDVLDM
610 620 630 640 650
AQIDAGEMAL EIEDIRVSDL LLNAQERALK DAQLGGVTLA VECEEDVGLI
660 670 680 690 700
RGDGKRLAQT LDHLVENALR QTPPGGRVTL SARRALGEVR LDVSDTGRGV
710 720 730 740 750
PFHVQAHIFD RFVGRDRGGP GLGLALVKAL VELHGGWVAL ESEPGNGSTF
760
TCHLPETQQP GAMQPELGF
Length:769
Mass (Da):82,796
Last modified:July 11, 2002 - v2
Checksum:i002B2428F18A57EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001Q → H in AAF08344 (PubMed:10557274).Curated
Sequence conflicti216 – 2161V → E in AAF08344 (PubMed:10557274).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083422 Genomic DNA. Translation: AAF08344.2.
AE005673 Genomic DNA. Translation: AAK25446.1.
PIRiB87681.
RefSeqiNP_422278.1. NC_002696.2.
WP_010921313.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK25446; AAK25446; CC_3484.
GeneIDi943276.
KEGGiccr:CC_3484.
PATRICi21304004. VBICauCre124313_3494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083422 Genomic DNA. Translation: AAF08344.2.
AE005673 Genomic DNA. Translation: AAK25446.1.
PIRiB87681.
RefSeqiNP_422278.1. NC_002696.2.
WP_010921313.1. NC_002696.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q20X-ray2.50A/B523-769[»]
ProteinModelPortaliQ9RQQ9.
SMRiQ9RQQ9. Positions 526-758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_3484.

PTM databases

iPTMnetiQ9RQQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK25446; AAK25446; CC_3484.
GeneIDi943276.
KEGGiccr:CC_3484.
PATRICi21304004. VBICauCre124313_3494.

Phylogenomic databases

eggNOGiENOG4105I8F. Bacteria.
ENOG410Y097. LUCA.
HOGENOMiHOG000226687.
KOiK00936.
OMAiLKNDFVQ.

Enzyme and pathway databases

BioCyciCAULO:CC3484-MONOMER.
BRENDAi2.7.13.3. 1218.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIVL_CAUCR
AccessioniPrimary (citable) accession number: Q9RQQ9
Secondary accession number(s): Q9A2S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.