Reviewed, UniProtKB/Swiss-Prot Q9RQQ9 (DIVL_CAUCR)

Names and origin

Protein names

Recommended name:
    Sensor protein divL
    EC=2.7.13.3

Gene names

Name:	divL
Ordered Locus Names:	CC_3484

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	769 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell membrane; Single-pass membrane protein.
Post-translational modification	Autophosphorylated. Ref.1
Sequence similarities	Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 769	769	Sensor protein divL		PRO_0000074729
Regions
	Transmembrane	6 – 26	21	Potential
	Domain	547 – 758	212	Histidine kinase
	Compositional bias	9 – 221	213	Ala-rich
Amino acid modifications
	Modified residue	550	1	Phosphotyrosine; by autocatalysis Ref.1
Experimental info
	Sequence conflict	200	1	Q → H in AAF08344. Ref.1
	Sequence conflict	216	1	V → E in AAF08344. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9RQQ9-1 [UniParc]. Last modified July 11, 2002. Version 2. Checksum: 002B2428F18A57EF	FASTA	769	82,796
	10 20 30 40 50 60 MTSYDLILAA AAGAVCLAIS VALWSHGQRR NLEARIVALK TRLIQQGGSD DAPAWLDAFD 70 80 90 100 110 120 TAVIAVEGGR ANLVAGGEGL IACAKALGAD AEVSAVVAAL SDADPNYAQK LTALFERGEP 130 140 150 160 170 180 CVFEARGPHG LVSVEGRAAG ALAWLRLAPI DRADSGLPTA ARFAAFVDSV VEPCWIAGAD 190 200 210 220 230 240 GQAIWGNAAF VRAVGAASAQ APALAGKSFD RGADAVVVEA AGKGERREAL RWINVEGRRR 250 260 270 280 290 300 AFRLSAQPLD GGGVGVFCAD VTEIEDVRDA FKKHVEAHDE TLNHIAEAVA IFSQTRRLSY 310 320 330 340 350 360 HNTAFAELWG LEPAWLADRP THGEVLDRLR QRRRLPETID YAGWKAAELA RYEDLGPQAD 370 380 390 400 410 420 DLWDLPDGRT LKVVRQPHPL GGMLLIYSDI TGELRLKAQY NALIQVQQAT LDKLNDAVAV 430 440 450 460 470 480 FGSDGRLRLH NEAFETFWNV TPHALEAAGD FEGVVELCVP RLHDLSFWRE LKGRVADPDP 490 500 510 520 530 540 QMRAPTSGEV RTSDSRIVLY QSRPLPDGAT LIAFADVTDT RDLQSALADR SAALAEAERL 550 560 570 580 590 600 KRDFVGNVSY ELRTPLTTII GYSELLERAD GISERGRNHV AAVRAAATQL ARSIDDVLDM 610 620 630 640 650 660 AQIDAGEMAL EIEDIRVSDL LLNAQERALK DAQLGGVTLA VECEEDVGLI RGDGKRLAQT 670 680 690 700 710 720 LDHLVENALR QTPPGGRVTL SARRALGEVR LDVSDTGRGV PFHVQAHIFD RFVGRDRGGP 730 740 750 760 GLGLALVKAL VELHGGWVAL ESEPGNGSTF TCHLPETQQP GAMQPELGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel bacterial tyrosine kinase essential for cell division and differentiation." Wu J., Ohta N., Zhao J.L., Newton A. Proc. Natl. Acad. Sci. U.S.A. 96:13068-13073(1999) [PubMed: 10557274] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PHOSPHORYLATION AT TYR-550. Strain: ATCC 19089 / CB15.
[2]	"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF083422 Genomic DNA. Translation: AAF08344.2. AE005673 Genomic DNA. Translation: AAK25446.1.
PIR	B87681.
RefSeq	NP_422278.1.
3D structure databases
ModBase	Search...
PTM databases
PhosSite	Q9RQQ9.
Genome annotation databases
GeneID	943276.
GenomeReviews	Gene locus CC_3484 in contig AE005673_GR.
KEGG	ccr:CC_3484.
NMPDR	fig|190650.1.peg.3458.
TIGR	CC_3484.
Phylogenomic databases
HOGENOM	Q9RQQ9.
OMA	HHVSYEL
Enzyme and pathway databases
BRENDA	2.7.13.3. 2191.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR013656. PAS_4. IPR004358. Sig_transdc_His_kin-like_C. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. PF08448. PAS_4. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
PROSITE	PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DIVL_CAUCR

Accession

Primary (citable) accession number: Q9RQQ9
Secondary accession number(s): Q9A2S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	July 11, 2002
Last modified:	November 24, 2009
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)