Q9RQ51 (ILVC_BUCSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:

ilvC

Organism

Buchnera aphidicola subsp. Schlechtendalia chinensis

Taxonomic identifier

118110 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_0000151292
Sites
	Active site	131	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9RQ51 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BFB94B15F507641F	FASTA	489	55,710
	10 20 30 40 50 60 MNYFNSLNFR QKLINLRKCK LVEKNFFSKK CDILKRKNIV IVGCGSQGLN QGLNMRDSGL 70 80 90 100 110 120 HVSYALRGSS ILNKNKSWEN ATKNNFFVDT YENIIPTADL VINLTPDKQR KEVVTLLQKF 130 140 150 160 170 180 MKENSVLGFS HGFHIVEIGQ KIRNDITVIM VAPKCPGTEV REEYKKGFGV PSLIAVHMEN 190 200 210 220 230 240 DPKKIGFEIA KAWAYSLGSH RAGVLHSSFI AEVKSDLMGE QTILCGMLQT SSLVCYDQLV 250 260 270 280 290 300 SQGKDPNYAG KLIQLGWESI TESVKHGGIT LMLNRLSNTA KIRAYILSKK LKVMFSSLFR 310 320 330 340 350 360 KHMDDIISGE FSKNMIDDWN SDDKKLKEWR TQIKKTDFEK CKICHKEISE QEYFDQGLLM 370 380 390 400 410 420 VAILKAGIEL SFEIMVETGI KEESAYYESL HELPLIANTI ARKRLYEMNL VISDTAEYGS 430 440 450 460 470 480 YLFSQSAIPL LKEFMNELCP GDLGEKISDL QFDNVTLNKI NHDIENHPVE IIGKKLRKYM VDMKPIKLS

References

[1]	"Sequence evolution in bacterial endosymbionts having extreme base compositions." Clark M.A., Moran N.A., Baumann P. Mol. Biol. Evol. 16:1586-1598(1999) [PubMed: 10555290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF130813 Genomic DNA. Translation: AAF13803.1.
3D structure databases
ProteinModelPortal	Q9RQ51.
SMR	Q9RQ51. Positions 2-488.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. IPR014359. KetolA_reductoisomerase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit. PTHR21371:SF2. PTHR21371:SF2. 1 hit.
Pfam	PF01450. IlvC. 2 hits. PF07991. IlvN. 1 hit. [Graphical view]
PIRSF	PIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_BUCSC

Accession

Primary (citable) accession number: Q9RQ51

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	May 1, 2000
Last modified:	June 28, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program