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Q9RQ13 (FUCI_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase

EC=5.3.1.25
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene names
Name:fucI
Ordered Locus Names:BT_1273
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose Probable. HAMAP-Rule MF_01254

Catalytic activity

L-fucopyranose = L-fuculose. HAMAP-Rule MF_01254

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Fucose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-fucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-fucose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591L-fucose isomerase HAMAP-Rule MF_01254
PRO_0000204143

Sites

Active site3381Proton acceptor By similarity
Active site3621Proton acceptor By similarity
Metal binding3381Manganese By similarity
Metal binding3621Manganese By similarity
Metal binding5291Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RQ13 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 96B5874825022432

FASTA59165,742
        10         20         30         40         50         60 
MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIS NNLKNGDGSP VECIIADNTI 

        70         80         90        100        110        120 
GRVAESAACA EKFEREGVGS TITVTSCWCY GAETMDMNPH YPKAVWGFNG TERPGAVYLA 

       130        140        150        160        170        180 
AVLAGHAQKG LPAFGIYGRD VQDLDDNTIP EDVAEKILRF ARAAQAVATM RGKSYLSMGS 

       190        200        210        220        230        240 
VSMGIAGSIV NPDFFQEYLG MRNESIDLTE IIRRMEEGIY DHEEYAKAMA WTEKYCKVNE 

       250        260        270        280        290        300 
GEDFKNRPEK RKKREQKDAD WEFVVKMMII MRDLMTGNPK LKEMGFKEEA LGHNAIAAGF 

       310        320        330        340        350        360 
QGQRQWTDFY PNGDYPEALL NTSFDWNGIR EAFVVATEND ACNGVAMLFG HLLTNRAQIF 

       370        380        390        400        410        420 
SDVRTYWSPE AVKRVTGKEL TGLAANGIIH LINSGATTLD GSGQSLDAEG NPVMKEPWNL 

       430        440        450        460        470        480 
TDADVENCLK ATTWYPADRD YFRGGGFSSN FLSKGGMPVT MMRLNLIKGL GPVLQIAEGW 

       490        500        510        520        530        540 
TVEIDPEIHQ KLNMRTDPTW PTTWFVPRLC DKSAFKDVYS VMNNWGANHG AISYGHIGQD 

       550        560        570        580        590 
LITLASMLRI PVCMHNVDEN EIFRPTAWNA FGMDKEGADY RACTTYGPIY K 

« Hide

References

« Hide 'large scale' references
[1]"A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem."
Hooper L.V., Xu J., Falk P.G., Midtvedt T., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 96:9833-9838(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
[2]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF137263 Genomic DNA. Translation: AAF01484.1.
AE015928 Genomic DNA. Translation: AAO76380.1.
RefSeqNP_810186.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ9RQ13.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_1273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO76380; AAO76380; BT_1273.
GeneID1073391.
KEGGbth:BT_1273.
PATRIC21057387. VBIBacThe70966_1300.

Phylogenomic databases

eggNOGCOG2407.
KOK01818.
OMAFWEISDE.
OrthoDBEOG6FJNCF.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-1295-MONOMER.
UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCI_BACTN
AccessionPrimary (citable) accession number: Q9RQ13
Secondary accession number(s): Q7C426
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways