Q9RQ13 (FUCI_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fucose isomerase
EC=5.3.1.25

Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase

Gene names

Name:	fucI
Ordered Locus Names:	BT_1273

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides › Bacteroides thetaiotaomicron

Protein attributes

Sequence length	591 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts the aldose L-fucose into the corresponding ketose L-fuculose Probable. HAMAP-Rule MF_01254
Catalytic activity	L-fucose = L-fuculose. HAMAP-Rule MF_01254
Cofactor	Manganese By similarity. HAMAP-Rule MF_01254
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01254.
Sequence similarities	Belongs to the L-fucose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fucose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-fucose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 591	591	L-fucose isomerase HAMAP-Rule MF_01254		PRO_0000204143
Sites
	Active site	338	1	Proton acceptor By similarity
	Active site	362	1	Proton acceptor By similarity
	Metal binding	338	1	Manganese By similarity
	Metal binding	362	1	Manganese By similarity
	Metal binding	529	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RQ13 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 96B5874825022432	FASTA	591	65,742
	10 20 30 40 50 60 MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIS NNLKNGDGSP VECIIADNTI 70 80 90 100 110 120 GRVAESAACA EKFEREGVGS TITVTSCWCY GAETMDMNPH YPKAVWGFNG TERPGAVYLA 130 140 150 160 170 180 AVLAGHAQKG LPAFGIYGRD VQDLDDNTIP EDVAEKILRF ARAAQAVATM RGKSYLSMGS 190 200 210 220 230 240 VSMGIAGSIV NPDFFQEYLG MRNESIDLTE IIRRMEEGIY DHEEYAKAMA WTEKYCKVNE 250 260 270 280 290 300 GEDFKNRPEK RKKREQKDAD WEFVVKMMII MRDLMTGNPK LKEMGFKEEA LGHNAIAAGF 310 320 330 340 350 360 QGQRQWTDFY PNGDYPEALL NTSFDWNGIR EAFVVATEND ACNGVAMLFG HLLTNRAQIF 370 380 390 400 410 420 SDVRTYWSPE AVKRVTGKEL TGLAANGIIH LINSGATTLD GSGQSLDAEG NPVMKEPWNL 430 440 450 460 470 480 TDADVENCLK ATTWYPADRD YFRGGGFSSN FLSKGGMPVT MMRLNLIKGL GPVLQIAEGW 490 500 510 520 530 540 TVEIDPEIHQ KLNMRTDPTW PTTWFVPRLC DKSAFKDVYS VMNNWGANHG AISYGHIGQD 550 560 570 580 590 LITLASMLRI PVCMHNVDEN EIFRPTAWNA FGMDKEGADY RACTTYGPIY K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem." Hooper L.V., Xu J., Falk P.G., Midtvedt T., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 96:9833-9838(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
[2]	"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF137263 Genomic DNA. Translation: AAF01484.1. AE015928 Genomic DNA. Translation: AAO76380.1.
RefSeq	NP_810186.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q9RQ13.
ModBase	Search...
Protein-protein interaction databases
STRING	226186.BT_1273.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO76380; AAO76380; BT_1273.
GeneID	1073391.
KEGG	bth:BT_1273.
PATRIC	21057387. VBIBacThe70966_1300.
Phylogenomic databases
eggNOG	COG2407.
KO	K01818.
OMA	KIGIRPT.
ProtClustDB	PRK10991.
Enzyme and pathway databases
BioCyc	BTHE226186:GJXV-1295-MONOMER.
UniPathway	UPA00563; UER00624.
Family and domain databases
Gene3D	3.20.14.10. 1 hit. 3.40.275.10. 1 hit. 3.40.50.1070. 1 hit.
HAMAP	MF_01254. Fucose_iso.
InterPro	IPR004216. Fuc/Ara_isomerase_C. IPR015888. Fuc_isomerase_C. IPR012888. Fucose_iso_N1. IPR005763. Fucose_isomerase. IPR009015. Fucose_isomerase_N/cen. IPR012889. Fucose_isomerase_N2. [Graphical view]
Pfam	PF02952. Fucose_iso_C. 1 hit. PF07881. Fucose_iso_N1. 1 hit. PF07882. Fucose_iso_N2. 1 hit. [Graphical view]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
TIGRFAMs	TIGR01089. fucI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCI_BACTN

Accession

Primary (citable) accession number: Q9RQ13
Secondary accession number(s): Q7C426

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program