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Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.Curated

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Proton acceptorUniRule annotation1
Metal bindingi338ManganeseUniRule annotation1
Active sitei362Proton acceptorUniRule annotation1
Metal bindingi362ManganeseUniRule annotation1
Metal bindingi529ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciBTHE:G13PU-6197-MONOMER
UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:BT_1273
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041431 – 591L-fucose isomeraseAdd BLAST591

Proteomic databases

PaxDbiQ9RQ13
PRIDEiQ9RQ13

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_1273

Structurei

3D structure databases

ProteinModelPortaliQ9RQ13
SMRiQ9RQ13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EHF Bacteria
COG2407 LUCA
InParanoidiQ9RQ13
KOiK01818
OMAiHAQKGLP
OrthoDBiPOG091H0GT3

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RQ13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIS NNLKNGDGSP
60 70 80 90 100
VECIIADNTI GRVAESAACA EKFEREGVGS TITVTSCWCY GAETMDMNPH
110 120 130 140 150
YPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGRD VQDLDDNTIP
160 170 180 190 200
EDVAEKILRF ARAAQAVATM RGKSYLSMGS VSMGIAGSIV NPDFFQEYLG
210 220 230 240 250
MRNESIDLTE IIRRMEEGIY DHEEYAKAMA WTEKYCKVNE GEDFKNRPEK
260 270 280 290 300
RKKREQKDAD WEFVVKMMII MRDLMTGNPK LKEMGFKEEA LGHNAIAAGF
310 320 330 340 350
QGQRQWTDFY PNGDYPEALL NTSFDWNGIR EAFVVATEND ACNGVAMLFG
360 370 380 390 400
HLLTNRAQIF SDVRTYWSPE AVKRVTGKEL TGLAANGIIH LINSGATTLD
410 420 430 440 450
GSGQSLDAEG NPVMKEPWNL TDADVENCLK ATTWYPADRD YFRGGGFSSN
460 470 480 490 500
FLSKGGMPVT MMRLNLIKGL GPVLQIAEGW TVEIDPEIHQ KLNMRTDPTW
510 520 530 540 550
PTTWFVPRLC DKSAFKDVYS VMNNWGANHG AISYGHIGQD LITLASMLRI
560 570 580 590
PVCMHNVDEN EIFRPTAWNA FGMDKEGADY RACTTYGPIY K
Length:591
Mass (Da):65,742
Last modified:May 1, 2000 - v1
Checksum:i96B5874825022432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137263 Genomic DNA Translation: AAF01484.1
AE015928 Genomic DNA Translation: AAO76380.1
RefSeqiNP_810186.1, NC_004663.1
WP_011107686.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO76380; AAO76380; BT_1273
GeneIDi1073391
KEGGibth:BT_1273
PATRICifig|226186.12.peg.1300

Similar proteinsi

Entry informationi

Entry nameiFUCI_BACTN
AccessioniPrimary (citable) accession number: Q9RQ13
Secondary accession number(s): Q7C426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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