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Q9RQ13

- FUCI_BACTN

UniProt

Q9RQ13 - FUCI_BACTN

Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.Curated

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei338 – 3381Proton acceptorUniRule annotation
    Metal bindingi338 – 3381ManganeseUniRule annotation
    Active sitei362 – 3621Proton acceptorUniRule annotation
    Metal bindingi362 – 3621ManganeseUniRule annotation
    Metal bindingi529 – 5291ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-1295-MONOMER.
    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:BT_1273
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591L-fucose isomerasePRO_0000204143Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_1273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RQ13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    KOiK01818.
    OMAiFWEISDE.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RQ13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIS NNLKNGDGSP    50
    VECIIADNTI GRVAESAACA EKFEREGVGS TITVTSCWCY GAETMDMNPH 100
    YPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGRD VQDLDDNTIP 150
    EDVAEKILRF ARAAQAVATM RGKSYLSMGS VSMGIAGSIV NPDFFQEYLG 200
    MRNESIDLTE IIRRMEEGIY DHEEYAKAMA WTEKYCKVNE GEDFKNRPEK 250
    RKKREQKDAD WEFVVKMMII MRDLMTGNPK LKEMGFKEEA LGHNAIAAGF 300
    QGQRQWTDFY PNGDYPEALL NTSFDWNGIR EAFVVATEND ACNGVAMLFG 350
    HLLTNRAQIF SDVRTYWSPE AVKRVTGKEL TGLAANGIIH LINSGATTLD 400
    GSGQSLDAEG NPVMKEPWNL TDADVENCLK ATTWYPADRD YFRGGGFSSN 450
    FLSKGGMPVT MMRLNLIKGL GPVLQIAEGW TVEIDPEIHQ KLNMRTDPTW 500
    PTTWFVPRLC DKSAFKDVYS VMNNWGANHG AISYGHIGQD LITLASMLRI 550
    PVCMHNVDEN EIFRPTAWNA FGMDKEGADY RACTTYGPIY K 591
    Length:591
    Mass (Da):65,742
    Last modified:May 1, 2000 - v1
    Checksum:i96B5874825022432
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137263 Genomic DNA. Translation: AAF01484.1.
    AE015928 Genomic DNA. Translation: AAO76380.1.
    RefSeqiNP_810186.1. NC_004663.1.
    WP_011107686.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO76380; AAO76380; BT_1273.
    GeneIDi1073391.
    KEGGibth:BT_1273.
    PATRICi21057387. VBIBacThe70966_1300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137263 Genomic DNA. Translation: AAF01484.1 .
    AE015928 Genomic DNA. Translation: AAO76380.1 .
    RefSeqi NP_810186.1. NC_004663.1.
    WP_011107686.1. NC_004663.1.

    3D structure databases

    ProteinModelPortali Q9RQ13.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_1273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO76380 ; AAO76380 ; BT_1273 .
    GeneIDi 1073391.
    KEGGi bth:BT_1273.
    PATRICi 21057387. VBIBacThe70966_1300.

    Phylogenomic databases

    eggNOGi COG2407.
    KOi K01818.
    OMAi FWEISDE.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .
    BioCyci BTHE226186:GJXV-1295-MONOMER.

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem."
      Hooper L.V., Xu J., Falk P.G., Midtvedt T., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 96:9833-9838(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
    2. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

    Entry informationi

    Entry nameiFUCI_BACTN
    AccessioniPrimary (citable) accession number: Q9RQ13
    Secondary accession number(s): Q7C426
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3