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Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.Curated

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathway:iL-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381Proton acceptorUniRule annotation
Metal bindingi338 – 3381ManganeseUniRule annotation
Active sitei362 – 3621Proton acceptorUniRule annotation
Metal bindingi362 – 3621ManganeseUniRule annotation
Metal bindingi529 – 5291ManganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-1295-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:BT_1273
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591L-fucose isomerasePRO_0000204143Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_1273.

Structurei

3D structure databases

ProteinModelPortaliQ9RQ13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
InParanoidiQ9RQ13.
KOiK01818.
OMAiWGANHCV.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RQ13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIS NNLKNGDGSP
60 70 80 90 100
VECIIADNTI GRVAESAACA EKFEREGVGS TITVTSCWCY GAETMDMNPH
110 120 130 140 150
YPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGRD VQDLDDNTIP
160 170 180 190 200
EDVAEKILRF ARAAQAVATM RGKSYLSMGS VSMGIAGSIV NPDFFQEYLG
210 220 230 240 250
MRNESIDLTE IIRRMEEGIY DHEEYAKAMA WTEKYCKVNE GEDFKNRPEK
260 270 280 290 300
RKKREQKDAD WEFVVKMMII MRDLMTGNPK LKEMGFKEEA LGHNAIAAGF
310 320 330 340 350
QGQRQWTDFY PNGDYPEALL NTSFDWNGIR EAFVVATEND ACNGVAMLFG
360 370 380 390 400
HLLTNRAQIF SDVRTYWSPE AVKRVTGKEL TGLAANGIIH LINSGATTLD
410 420 430 440 450
GSGQSLDAEG NPVMKEPWNL TDADVENCLK ATTWYPADRD YFRGGGFSSN
460 470 480 490 500
FLSKGGMPVT MMRLNLIKGL GPVLQIAEGW TVEIDPEIHQ KLNMRTDPTW
510 520 530 540 550
PTTWFVPRLC DKSAFKDVYS VMNNWGANHG AISYGHIGQD LITLASMLRI
560 570 580 590
PVCMHNVDEN EIFRPTAWNA FGMDKEGADY RACTTYGPIY K
Length:591
Mass (Da):65,742
Last modified:May 1, 2000 - v1
Checksum:i96B5874825022432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137263 Genomic DNA. Translation: AAF01484.1.
AE015928 Genomic DNA. Translation: AAO76380.1.
RefSeqiNP_810186.1. NC_004663.1.
WP_011107686.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO76380; AAO76380; BT_1273.
GeneIDi1073391.
KEGGibth:BT_1273.
PATRICi21057387. VBIBacThe70966_1300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137263 Genomic DNA. Translation: AAF01484.1.
AE015928 Genomic DNA. Translation: AAO76380.1.
RefSeqiNP_810186.1. NC_004663.1.
WP_011107686.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ9RQ13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_1273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO76380; AAO76380; BT_1273.
GeneIDi1073391.
KEGGibth:BT_1273.
PATRICi21057387. VBIBacThe70966_1300.

Phylogenomic databases

eggNOGiCOG2407.
InParanoidiQ9RQ13.
KOiK01818.
OMAiWGANHCV.
OrthoDBiEOG6FJNCF.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.
BioCyciBTHE226186:GJXV-1295-MONOMER.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem."
    Hooper L.V., Xu J., Falk P.G., Midtvedt T., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 96:9833-9838(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
  2. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiFUCI_BACTN
AccessioniPrimary (citable) accession number: Q9RQ13
Secondary accession number(s): Q7C426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.