Q9RPY4 (VIRB1_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type IV secretion system protein virB1

Gene names

Name:	virB1
Ordered Locus Names:	BRA0069, BS1330_II0069

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The VirB system could be required for the establishment of the replication niche in the host. Ref.1
Induction	Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
Miscellaneous	Transcription of the operon is maximal in early exponential phase.
Sequence similarities	Belongs to the virb1 family.

Ontologies

Keywords
Biological process	Virulence
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Type IV secretion system protein virB1		PRO_0000289554

Sequences

	Sequence		Length	Mass (Da)
	Q9RPY4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A8CDE5C128DC61DD	FASTA	238	25,200
	10 20 30 40 50 60 MVPFLVLAQQ CAPTVAPQTM AAIVQVESGF NPYAIGVVGG RLVRQPVSLD EAITTAQSLE 70 80 90 100 110 120 AKGWNFSLGI AQVNRYNLPK YGSTYAQAFD PCKNLKMGSK ILEDCYRRAI VKMPGQEQGA 130 140 150 160 170 180 LRAAFSCYYA GNFTGGFKTK PGSPSYVQKV VASADVTTKP IAVVPMIRKT PDAAAAVAAP 190 200 210 220 230 VKKRQPADRN SVLVDLHPSS QSMPATGAAN APVRLKTEQP ATTDAPPGKD NTDGVVVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis." O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M. Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: 1330.
[2]	"The Brucella suis virB operon is induced intracellularly in macrophages." Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S., Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M., O'Callaghan D. Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS. Strain: 1330.
[3]	"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
[4]	"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF141604 Genomic DNA. Translation: AAD56611.1. AE014292 Genomic DNA. Translation: AAN33281.1. CP002998 Genomic DNA. Translation: AEM19561.1.
RefSeq	NP_699276.1. NC_004311.2. YP_005613787.1. NC_017250.1.
3D structure databases
ProteinModelPortal	Q9RPY4.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BRA0069.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN33281; AAN33281; BRA0069. AEM19561; AEM19561; BS1330_II0069.
GeneID	1164506. 12139503.
KEGG	bms:BRA0069. bsi:BS1330_II0069.
PATRIC	17792939. VBIBruSui107850_2288.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG06545.
HOGENOM	HOG000119040.
KO	K03194.
OMA	EDAFEPC.
ProtClustDB	CLSK884272.
Family and domain databases
InterPro	IPR023346. Lysozyme-like_dom. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VIRB1_BRUSU

Accession

Primary (citable) accession number: Q9RPY4
Secondary accession number(s): G0KER7, Q7CEF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program