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Q9RPY1

- VIRB4_BRUSU

UniProt

Q9RPY1 - VIRB4_BRUSU

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Protein

Type IV secretion system protein virB4

Gene
virB4, BRA0066, BS1330_II0066
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

The VirB system could be required for the establishment of the replication niche in the host.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi457 – 4648ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein virB4
Gene namesi
Name:virB4
Ordered Locus Names:BRA0066, BS1330_II0066
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Type IV secretion system protein virB4PRO_0000290171Add
BLAST

Expressioni

Inductioni

Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

Interactioni

Protein-protein interaction databases

STRINGi204722.BRA0066.

Structurei

3D structure databases

ProteinModelPortaliQ9RPY1.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrbE/VirB4 family.

Phylogenomic databases

eggNOGiCOG3451.
HOGENOMiHOG000119263.
KOiK03199.
OMAiRYFRIRT.
OrthoDBiEOG6HMX9P.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR004346. CagE_TrbE_VirB.
IPR018145. CagE_TrbE_VirB_cntrl_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03135. CagE_TrbE_VirB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00929. VirB4_CagE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RPY1-1 [UniParc]FASTAAdd to Basket

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MGAQSKYAQQ LNNERSLAPF IPFRSQVGPT TVITRDGDFV RTWRIAGLAF    50
ETQDKEELLI RKDQLNTLFR AIASNNVALW SHNVRRRTWD HLKSFFSNPF 100
CDALDKKYYG SFSGYRMMSN ELYLTVIYRP VPAKISRLFN VAVHRSHAEI 150
LQEQQLAIRK LDEIGNQIET SLRRYGGDDG RGIEVLSTYE DKHGALCSQQ 200
LEFYNFLLSG EWQKVRVPSC PLDEYLGTGW VYAGTETIEI RTANATRYAR 250
GIDFKDYASH TEPGILNGLM YSDYEYVITQ SFSFMTKRDG KEFLTRQKQR 300
LQNTEDGSAS QIMEMDIAID QLGRGDFVMG EYHYSLLVFA EDMETVRHNT 350
SHAMNILQDN GFLATVIATA TDAAFYAQLP CNWRYRPRVA GLTSLNFAGL 400
SCFHNFRAGK RDGNPWGQAL TLLKTPSGQP AYLNFHYSKG DEDNFDKKLL 450
GNTRIIGQSG AGKTVLMNFC LAQAQKYLHN APMGMCNVFF DKDQGAKGTI 500
LAIGGKYLAI RNGEPTGFNP FQMEPTAGNI LFLEKLVQVL VSRDGQHVTT 550
TDESRISHAI RTVMRMRPEL RRLSTVLQNV TEGSDRQDRE NSVAKRLAKW 600
CFDDGTGKRG TFWWVLDCPQ DQIDFNTHSN YGFDGTDFLD NADVRTPISM 650
YLLHRMELAI DGRRFIYWMD EAWKWVDDEA FSEFANNKQL TIRKQNGLGV 700
FATQMPSSLL NSKVASALVQ QVATEIYLPN PKADYHEYTD GFKVTNEEFD 750
IIRSMSEESR MFLVKQGHHS MICRLELNGF DDELAILSGS SDNNELLDQV 800
IAEVGDDPSV WLPVFQERRK ARIASSKSTG R 831
Length:831
Mass (Da):94,546
Last modified:June 12, 2007 - v2
Checksum:i3C8D3695FA986EE4
GO

Sequence cautioni

The sequence AAD56614.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801W → R in AAD56614. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141604 Genomic DNA. Translation: AAD56614.1. Different initiation.
AE014292 Genomic DNA. Translation: AAN33278.1.
CP002998 Genomic DNA. Translation: AEM19558.1.
RefSeqiNP_699273.1. NC_004311.2.
YP_005613784.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33278; AAN33278; BRA0066.
AEM19558; AEM19558; BS1330_II0066.
GeneIDi1164503.
12139500.
KEGGibms:BRA0066.
bsi:BS1330_II0066.
PATRICi17792933. VBIBruSui107850_2285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141604 Genomic DNA. Translation: AAD56614.1 . Different initiation.
AE014292 Genomic DNA. Translation: AAN33278.1 .
CP002998 Genomic DNA. Translation: AEM19558.1 .
RefSeqi NP_699273.1. NC_004311.2.
YP_005613784.1. NC_017250.1.

3D structure databases

ProteinModelPortali Q9RPY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BRA0066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN33278 ; AAN33278 ; BRA0066 .
AEM19558 ; AEM19558 ; BS1330_II0066 .
GeneIDi 1164503.
12139500.
KEGGi bms:BRA0066.
bsi:BS1330_II0066.
PATRICi 17792933. VBIBruSui107850_2285.

Phylogenomic databases

eggNOGi COG3451.
HOGENOMi HOG000119263.
KOi K03199.
OMAi RYFRIRT.
OrthoDBi EOG6HMX9P.

Miscellaneous databases

PROi Q9RPY1.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR004346. CagE_TrbE_VirB.
IPR018145. CagE_TrbE_VirB_cntrl_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF03135. CagE_TrbE_VirB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00929. VirB4_CagE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis."
    O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.
    Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS.
    Strain: 1330.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiVIRB4_BRUSU
AccessioniPrimary (citable) accession number: Q9RPY1
Secondary accession number(s): G0KER4, Q8FXK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription of the operon is maximal in early exponential phase.

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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