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Q9RPY1

- VIRB4_BRUSU

UniProt

Q9RPY1 - VIRB4_BRUSU

Protein

Type IV secretion system protein virB4

Gene

virB4

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    The VirB system could be required for the establishment of the replication niche in the host.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi457 – 4648ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type IV secretion system protein virB4
    Gene namesi
    Name:virB4
    Ordered Locus Names:BRA0066, BS1330_II0066
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 831831Type IV secretion system protein virB4PRO_0000290171Add
    BLAST

    Expressioni

    Inductioni

    Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BRA0066.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RPY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrbE/VirB4 family.Curated

    Phylogenomic databases

    eggNOGiCOG3451.
    HOGENOMiHOG000119263.
    KOiK03199.
    OMAiRYFRIRT.
    OrthoDBiEOG6HMX9P.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR004346. CagE_TrbE_VirB.
    IPR018145. CagE_TrbE_VirB_cntrl_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF03135. CagE_TrbE_VirB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00929. VirB4_CagE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RPY1-1 [UniParc]FASTAAdd to Basket

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    MGAQSKYAQQ LNNERSLAPF IPFRSQVGPT TVITRDGDFV RTWRIAGLAF    50
    ETQDKEELLI RKDQLNTLFR AIASNNVALW SHNVRRRTWD HLKSFFSNPF 100
    CDALDKKYYG SFSGYRMMSN ELYLTVIYRP VPAKISRLFN VAVHRSHAEI 150
    LQEQQLAIRK LDEIGNQIET SLRRYGGDDG RGIEVLSTYE DKHGALCSQQ 200
    LEFYNFLLSG EWQKVRVPSC PLDEYLGTGW VYAGTETIEI RTANATRYAR 250
    GIDFKDYASH TEPGILNGLM YSDYEYVITQ SFSFMTKRDG KEFLTRQKQR 300
    LQNTEDGSAS QIMEMDIAID QLGRGDFVMG EYHYSLLVFA EDMETVRHNT 350
    SHAMNILQDN GFLATVIATA TDAAFYAQLP CNWRYRPRVA GLTSLNFAGL 400
    SCFHNFRAGK RDGNPWGQAL TLLKTPSGQP AYLNFHYSKG DEDNFDKKLL 450
    GNTRIIGQSG AGKTVLMNFC LAQAQKYLHN APMGMCNVFF DKDQGAKGTI 500
    LAIGGKYLAI RNGEPTGFNP FQMEPTAGNI LFLEKLVQVL VSRDGQHVTT 550
    TDESRISHAI RTVMRMRPEL RRLSTVLQNV TEGSDRQDRE NSVAKRLAKW 600
    CFDDGTGKRG TFWWVLDCPQ DQIDFNTHSN YGFDGTDFLD NADVRTPISM 650
    YLLHRMELAI DGRRFIYWMD EAWKWVDDEA FSEFANNKQL TIRKQNGLGV 700
    FATQMPSSLL NSKVASALVQ QVATEIYLPN PKADYHEYTD GFKVTNEEFD 750
    IIRSMSEESR MFLVKQGHHS MICRLELNGF DDELAILSGS SDNNELLDQV 800
    IAEVGDDPSV WLPVFQERRK ARIASSKSTG R 831
    Length:831
    Mass (Da):94,546
    Last modified:June 12, 2007 - v2
    Checksum:i3C8D3695FA986EE4
    GO

    Sequence cautioni

    The sequence AAD56614.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801W → R in AAD56614. (PubMed:10510235)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF141604 Genomic DNA. Translation: AAD56614.1. Different initiation.
    AE014292 Genomic DNA. Translation: AAN33278.1.
    CP002998 Genomic DNA. Translation: AEM19558.1.
    RefSeqiNP_699273.1. NC_004311.2.
    YP_005613784.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN33278; AAN33278; BRA0066.
    AEM19558; AEM19558; BS1330_II0066.
    GeneIDi1164503.
    12139500.
    KEGGibms:BRA0066.
    bsi:BS1330_II0066.
    PATRICi17792933. VBIBruSui107850_2285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF141604 Genomic DNA. Translation: AAD56614.1 . Different initiation.
    AE014292 Genomic DNA. Translation: AAN33278.1 .
    CP002998 Genomic DNA. Translation: AEM19558.1 .
    RefSeqi NP_699273.1. NC_004311.2.
    YP_005613784.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali Q9RPY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA0066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN33278 ; AAN33278 ; BRA0066 .
    AEM19558 ; AEM19558 ; BS1330_II0066 .
    GeneIDi 1164503.
    12139500.
    KEGGi bms:BRA0066.
    bsi:BS1330_II0066.
    PATRICi 17792933. VBIBruSui107850_2285.

    Phylogenomic databases

    eggNOGi COG3451.
    HOGENOMi HOG000119263.
    KOi K03199.
    OMAi RYFRIRT.
    OrthoDBi EOG6HMX9P.

    Miscellaneous databases

    PROi Q9RPY1.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR004346. CagE_TrbE_VirB.
    IPR018145. CagE_TrbE_VirB_cntrl_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF03135. CagE_TrbE_VirB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00929. VirB4_CagE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis."
      O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.
      Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS.
      Strain: 1330.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiVIRB4_BRUSU
    AccessioniPrimary (citable) accession number: Q9RPY1
    Secondary accession number(s): G0KER4, Q8FXK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transcription of the operon is maximal in early exponential phase.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3