Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9RPX3 (YU58_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type IV secretion system putative outer membrane lipoprotein BRA0058/BS1330_II0058
Gene names
Ordered Locus Names:BRA0058, BS1330_II0058
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The VirB system could be required for the establishment of the replication niche in the host.

Subcellular location

Cell outer membrane; Lipid-anchor Potential.

Induction

Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

Miscellaneous

Transcription of the operon is maximal in early exponential phase.

Sequence similarities

Contains 1 OmpA-like domain.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell outer membrane
Membrane
   DomainSignal
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 172157Type IV secretion system putative outer membrane lipoprotein BRA0058/BS1330_II0058
PRO_0000291448

Regions

Domain58 – 172115OmpA-like

Amino acid modifications

Lipidation161N-palmitoyl cysteine Potential
Lipidation161S-diacylglycerol cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q9RPX3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0A71CF3C0BB074C8

FASTA17218,991
        10         20         30         40         50         60 
MRTLVMVACA VSLAACSSPP KPPTVSGRHR IPINSPAAQE ELRLQVFPQE PTAQATMWPA 

        70         80         90        100        110        120 
RPPKQTVSVY FPQDVTVFRP TSAQINQLHT LLWPVPKHIN VRGLTDNNCP PPGDTQVARV 

       130        140        150        160        170 
RALAIYNWLI NQGVSASRIT ISYAPVKDYA SNAPLSPGRV LNRRVDIEIL RK 

« Hide

References

« Hide 'large scale' references
[1]"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis."
O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.
Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1330.
[2]"The Brucella suis virB operon is induced intracellularly in macrophages."
Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S., Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M., O'Callaghan D.
Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS.
Strain: 1330.
[3]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[4]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF141604 Genomic DNA. Translation: AAD56622.1.
AE014292 Genomic DNA. Translation: AAN33270.1.
CP002998 Genomic DNA. Translation: AEM19550.1.
RefSeqNP_699265.1. NC_004311.2.
YP_005613776.1. NC_017250.1.

3D structure databases

ProteinModelPortalQ9RPX3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BRA0058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN33270; AAN33270; BRA0058.
AEM19550; AEM19550; BS1330_II0058.
GeneID1164495.
12139492.
KEGGbms:BRA0058.
bsi:BS1330_II0058.
PATRIC17792919. VBIBruSui107850_2278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2885.
HOGENOMHOG000289240.
OMANSQMAVE.
OrthoDBEOG6PP9QB.
ProtClustDBCLSK884257.

Family and domain databases

Gene3D3.30.1330.60. 1 hit.
InterProIPR006665. OmpA/MotB_C.
[Graphical view]
PfamPF00691. OmpA. 1 hit.
[Graphical view]
SUPFAMSSF103088. SSF103088. 1 hit.
PROSITEPS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYU58_BRUSU
AccessionPrimary (citable) accession number: Q9RPX3
Secondary accession number(s): G0KEQ6, Q7CEG5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names