Q9RPX3 (YU58_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type IV secretion system putative outer membrane lipoprotein BRA0058/BS1330_II0058

Gene names

Ordered Locus Names:

BRA0058, BS1330_II0058

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The VirB system could be required for the establishment of the replication niche in the host.
Subcellular location	Cell outer membrane; Lipid-anchor Potential.
Induction	Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
Miscellaneous	Transcription of the operon is maximal in early exponential phase.
Sequence similarities	Contains 1 OmpA-like domain.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 172	157	Type IV secretion system putative outer membrane lipoprotein BRA0058/BS1330_II0058		PRO_0000291448
Regions
	Domain	58 – 172	115	OmpA-like
Amino acid modifications
	Lipidation	16	1	N-palmitoyl cysteine Potential
	Lipidation	16	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9RPX3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0A71CF3C0BB074C8	FASTA	172	18,991
	10 20 30 40 50 60 MRTLVMVACA VSLAACSSPP KPPTVSGRHR IPINSPAAQE ELRLQVFPQE PTAQATMWPA 70 80 90 100 110 120 RPPKQTVSVY FPQDVTVFRP TSAQINQLHT LLWPVPKHIN VRGLTDNNCP PPGDTQVARV 130 140 150 160 170 RALAIYNWLI NQGVSASRIT ISYAPVKDYA SNAPLSPGRV LNRRVDIEIL RK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis." O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M. Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1330.
[2]	"The Brucella suis virB operon is induced intracellularly in macrophages." Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S., Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M., O'Callaghan D. Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS. Strain: 1330.
[3]	"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
[4]	"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF141604 Genomic DNA. Translation: AAD56622.1. AE014292 Genomic DNA. Translation: AAN33270.1. CP002998 Genomic DNA. Translation: AEM19550.1.
RefSeq	NP_699265.1. NC_004311.2. YP_005613776.1. NC_017250.1.
3D structure databases
ProteinModelPortal	Q9RPX3.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BRA0058.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN33270; AAN33270; BRA0058. AEM19550; AEM19550; BS1330_II0058.
GeneID	1164495. 12139492.
KEGG	bms:BRA0058. bsi:BS1330_II0058.
PATRIC	17792919. VBIBruSui107850_2278.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2885.
HOGENOM	HOG000289240.
OMA	MAVELQV.
ProtClustDB	CLSK884257.
Family and domain databases
Gene3D	3.30.1330.60. 1 hit.
InterPro	IPR006665. OmpA/MotB_C. [Graphical view]
Pfam	PF00691. OmpA. 1 hit. [Graphical view]
SUPFAM	SSF103088. OmpA/MotB_C. 1 hit.
PROSITE	PS01068. OMPA_1. False negative. PS51123. OMPA_2. 1 hit. PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YU58_BRUSU

Accession

Primary (citable) accession number: Q9RPX3
Secondary accession number(s): G0KEQ6, Q7CEG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program