SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9RPU5

- HPAG_SALDU

UniProt

Q9RPU5 - HPAG_SALDU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase
Gene
hpaG
Organism
Salmonella dublin
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5-tricarboxylic acid) into HHDD (2-hydroxy-hept-2,4-diene-1,7-dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate).

Catalytic activityi

5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.
5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2.

Cofactori

Magnesium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi276 – 2761Divalent metal cation By similarity
Metal bindingi278 – 2781Divalent metal cation By similarity
Metal bindingi307 – 3071Divalent metal cation By similarity

GO - Molecular functioni

  1. 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity Source: UniProtKB-EC
  2. 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 4-hydroxyphenylacetate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00208; UER00419.
UPA00208; UER00420.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase
Including the following 2 domains:
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC:5.3.3.10)
Short name:
HHDD isomerase
Alternative name(s):
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (EC:4.1.1.68)
Alternative name(s):
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
Short name:
OPET decarboxylase
Gene namesi
Name:hpaG
OrganismiSalmonella dublin
Taxonomic identifieri98360 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4294294-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase
PRO_0000156834Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9RPU5.
SMRiQ9RPU5. Positions 1-428.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 215215Approximate
Add
BLAST
Repeati216 – 429214Approximate
Add
BLAST

Sequence similaritiesi

Belongs to the FAH family.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di3.90.850.10. 2 hits.
InterProiIPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR012684. HPA_isomer/decarb_C.
IPR012686. HPA_isomer/decarb_N.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 2 hits.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 2 hits.
TIGRFAMsiTIGR02303. HpaG-C-term. 1 hit.
TIGR02305. HpaG-N-term. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RPU5-1 [UniParc]FASTAAdd to Basket

« Hide

MKGTVFAVAL NHRSQLDAWQ EAFSQPPYNA PPKTAVWFIK PRNTVIRHGE    50
PILYPQGEKV LSGATVALIV GKTASRKRSE AAAEYIAGYA LANEVSLPEE 100
SFYRPAIKAK CRDGFCPLGE MAPLSDVDNL TIITEINGRE ADHWNTADLQ 150
RSAAQLLSAL SEFATLNPGD AILLGTPQNR VALRPGDRVR ILAKGLPALE 200
NPVVAEDEFA RNQTFTWPLS ATGTLFALGL NYADHASELA FTPPKEPLVF 250
IKAPNTFTEH HQTSVRPNNV EYMHYEAELV VVIGKTARKV SEAEAMEYVA 300
GYTVCNDYAI RDYLENYYRP NLRVKSRDGL TPIGPWIVDK EAVSDPHNLT 350
LRTFVNGELR QEGTTADLIF SIPFLISYLS EFMTLQPGDM IATGTPKGLS 400
DVVPGDEVVL EIKGVGRLVN QIVCEESAN 429
Length:429
Mass (Da):47,186
Last modified:May 1, 2000 - v1
Checksum:iD32723999AC4084E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF144422 Genomic DNA. Translation: AAD53501.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF144422 Genomic DNA. Translation: AAD53501.1 .

3D structure databases

ProteinModelPortali Q9RPU5.
SMRi Q9RPU5. Positions 1-428.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00208 ; UER00419 .
UPA00208 ; UER00420 .

Family and domain databases

Gene3Di 3.90.850.10. 2 hits.
InterProi IPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR012684. HPA_isomer/decarb_C.
IPR012686. HPA_isomer/decarb_N.
[Graphical view ]
Pfami PF01557. FAA_hydrolase. 2 hits.
[Graphical view ]
SUPFAMi SSF56529. SSF56529. 2 hits.
TIGRFAMsi TIGR02303. HpaG-C-term. 1 hit.
TIGR02305. HpaG-N-term. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of the hpa genetic locus from Salmonella dublin."
    Galyov E.E., Wood M.W., Hedges S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2229.

Entry informationi

Entry nameiHPAG_SALDU
AccessioniPrimary (citable) accession number: Q9RPU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi