Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide exchange factor SopE

Gene

sopE

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).By similarity

Miscellaneous

Encoded within a prophage region, which is only present in very few Salmonella isolates.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor
Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SopE
Alternative name(s):
Effector protein SopE
Toxin SopE
Gene namesi
Name:sopE
Ordered Locus Names:STY4609, t4303
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Secreted
  • Note: Secreted via the type III secretion system 1 (SPI-1 TTSS).

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002207392 – 240Guanine nucleotide exchange factor SopEAdd BLAST239

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi220341.STY4609

Structurei

3D structure databases

ProteinModelPortaliQ9RPM6
SMRiQ9RPM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni78 – 240GEF catalytic domainBy similarityAdd BLAST163

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4106EWC Bacteria
ENOG410XV0S LUCA
HOGENOMiHOG000028399
KOiK13741
OMAiYATIYSE

Family and domain databases

Gene3Di1.10.4120.10, 1 hit
InterProiView protein in InterPro
IPR005414 SopE
IPR035949 SopE-like_GEF_dom_sf
IPR016019 SopE_GEF_dom
IPR016018 SopE_N_dom
PfamiView protein in Pfam
PF05364 SecIII_SopE_N, 1 hit
PF07487 SopE_GEF, 1 hit
PIRSFiPIRSF034781 SecIII_sopE, 1 hit
PRINTSiPR01593 SOPEPROTEIN
SUPFAMiSSF81832 SSF81832, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RPM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKITLSPQN FRIQKQETTL LKEKSTEKNS LAKSILAVKN HFIELRSKLS
60 70 80 90 100
ERFISHKNTE SSATHFHRGS ASEGRAVLTN KVVKDFMLQT LNDIDIRGSA
110 120 130 140 150
SKDPAYASQT REAILSAVYS KNKDQCCNLL ISKGINIAPF LQEIGEAAKN
160 170 180 190 200
AGLPGTTKND VFTPSGAGAN PFITPLISSA NSKYPRMFIN QHQQASFKIY
210 220 230 240
AEKIIMTEVA PLFNECAMPT PQQFQLILEN IANKYIQYTP
Length:240
Mass (Da):26,685
Last modified:January 23, 2007 - v3
Checksum:iF636E9D437018D03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153829 Genomic DNA Translation: AAD54239.1
AL513382 Genomic DNA Translation: CAD06731.1
AE014613 Genomic DNA Translation: AAO71759.1
PIRiAF1035
RefSeqiNP_458691.1, NC_003198.1
WP_000161708.1, NZ_PHKG01000011.1

Genome annotation databases

EnsemblBacteriaiAAO71759; AAO71759; t4303
CAD06731; CAD06731; CAD06731
GeneIDi1250812
KEGGistt:t4303
sty:STY4609
PATRICifig|220341.7.peg.4707

Similar proteinsi

Entry informationi

Entry nameiSOPE_SALTI
AccessioniPrimary (citable) accession number: Q9RPM6
Secondary accession number(s): Q7ALR5, Q7C5D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 94 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health