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Protein

Guanine nucleotide exchange factor SopE

Gene

sopE

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SopE
Alternative name(s):
Effector protein SopE
Toxin SopE
Gene namesi
Name:sopE
Ordered Locus Names:STY4609, t4303
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Secreted

  • Note: Secreted via the type III secretion system 1 (SPI-1 TTSS).

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 240239Guanine nucleotide exchange factor SopEPRO_0000220739Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220341.STY4609.

Structurei

3D structure databases

ProteinModelPortaliQ9RPM6.
SMRiQ9RPM6. Positions 78-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 240163GEF catalytic domainBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4106EWC. Bacteria.
ENOG410XV0S. LUCA.
HOGENOMiHOG000028399.
KOiK13741.
OMAiYATIYSE.
OrthoDBiEOG6W71ZJ.

Family and domain databases

InterProiIPR005414. SopE.
IPR016019. SopE_GEF_dom.
IPR016018. SopE_N_dom.
[Graphical view]
PfamiPF05364. SecIII_SopE_N. 1 hit.
PF07487. SopE_GEF. 1 hit.
[Graphical view]
PIRSFiPIRSF034781. SecIII_sopE. 1 hit.
PRINTSiPR01593. SOPEPROTEIN.
SUPFAMiSSF81832. SSF81832. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RPM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKITLSPQN FRIQKQETTL LKEKSTEKNS LAKSILAVKN HFIELRSKLS
60 70 80 90 100
ERFISHKNTE SSATHFHRGS ASEGRAVLTN KVVKDFMLQT LNDIDIRGSA
110 120 130 140 150
SKDPAYASQT REAILSAVYS KNKDQCCNLL ISKGINIAPF LQEIGEAAKN
160 170 180 190 200
AGLPGTTKND VFTPSGAGAN PFITPLISSA NSKYPRMFIN QHQQASFKIY
210 220 230 240
AEKIIMTEVA PLFNECAMPT PQQFQLILEN IANKYIQYTP
Length:240
Mass (Da):26,685
Last modified:January 23, 2007 - v3
Checksum:iF636E9D437018D03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153829 Genomic DNA. Translation: AAD54239.1.
AL513382 Genomic DNA. Translation: CAD06731.1.
AE014613 Genomic DNA. Translation: AAO71759.1.
PIRiAF1035.
RefSeqiNP_458691.1. NC_003198.1.
WP_000161708.1. NZ_FFOG01000006.1.

Genome annotation databases

EnsemblBacteriaiAAO71759; AAO71759; t4303.
CAD06731; CAD06731; CAD06731.
GeneIDi1250812.
KEGGistt:t4303.
sty:STY4609.
PATRICi18547458. VBISalEnt120419_4707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153829 Genomic DNA. Translation: AAD54239.1.
AL513382 Genomic DNA. Translation: CAD06731.1.
AE014613 Genomic DNA. Translation: AAO71759.1.
PIRiAF1035.
RefSeqiNP_458691.1. NC_003198.1.
WP_000161708.1. NZ_FFOG01000006.1.

3D structure databases

ProteinModelPortaliQ9RPM6.
SMRiQ9RPM6. Positions 78-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY4609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO71759; AAO71759; t4303.
CAD06731; CAD06731; CAD06731.
GeneIDi1250812.
KEGGistt:t4303.
sty:STY4609.
PATRICi18547458. VBISalEnt120419_4707.

Phylogenomic databases

eggNOGiENOG4106EWC. Bacteria.
ENOG410XV0S. LUCA.
HOGENOMiHOG000028399.
KOiK13741.
OMAiYATIYSE.
OrthoDBiEOG6W71ZJ.

Family and domain databases

InterProiIPR005414. SopE.
IPR016019. SopE_GEF_dom.
IPR016018. SopE_N_dom.
[Graphical view]
PfamiPF05364. SecIII_SopE_N. 1 hit.
PF07487. SopE_GEF. 1 hit.
[Graphical view]
PIRSFiPIRSF034781. SecIII_sopE. 1 hit.
PRINTSiPR01593. SOPEPROTEIN.
SUPFAMiSSF81832. SSF81832. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a temperate bacteriophage encoding the type III effector protein SopE from an epidemic Salmonella typhimurium strain."
    Mirold S., Rabsch W., Rohde M., Stender S., Tschaepe H., Ruessmann H., Igwe E., Hardt W.-D.
    Proc. Natl. Acad. Sci. U.S.A. 96:9845-9850(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROPHAGE-RELATED REGION.
    Strain: x3744.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  3. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiSOPE_SALTI
AccessioniPrimary (citable) accession number: Q9RPM6
Secondary accession number(s): Q7ALR5, Q7C5D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded within a prophage region, which is only present in very few Salmonella isolates.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.