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Q9RNZ9

- TFDD_DELAC

UniProt

Q9RNZ9 - TFDD_DELAC

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Protein

Chloromuconate cycloisomerase

Gene

tfdD

Organism
Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate.

Cofactori

Manganese.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651Proton acceptorBy similarity
Metal bindingi194 – 1941ManganeseBy similarity
Metal bindingi220 – 2201ManganeseBy similarity
Metal bindingi245 – 2451ManganeseBy similarity
Active sitei323 – 3231Proton donorBy similarity

GO - Molecular functioni

  1. chloromuconate cycloisomerase activity Source: UniProtKB-EC
  2. manganese ion binding Source: InterPro
  3. muconate cycloisomerase activity Source: InterPro

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
  2. cellular amino acid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00083.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloromuconate cycloisomerase (EC:5.5.1.7)
Gene namesi
Name:tfdD
OrganismiDelftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
Taxonomic identifieri80866 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Chloromuconate cycloisomerasePRO_0000171258Add
BLAST

Expressioni

Inductioni

By 2,4-dichlorophenoxypropionic acid (2,4-DCPP).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9RNZ9.
SMRiQ9RNZ9. Positions 1-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR013370. Chloromuconate_cycloisomerase.
IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR02534. mucon_cyclo. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RNZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIEAISTTI VDVPTRRPLQ MSFTTVHKQS YVIVQVTAGG LVGIGEGGSV
60 70 80 90 100
GGPTWGSESA ETIKVIIDNY LAPLLIGKDA SNLSEARALM DRAVTGNLSA
110 120 130 140 150
KAAIDIALHD LKARALNLSI ADLIGGTMRK SIPIAWTLAS GDTARDIDSA
160 170 180 190 200
LEMIEARRHN RFKVKLGART PAQDLEHIRS IVKAVGDKAS VRVDVNQGWD
210 220 230 240 250
EQTASIWIPR LEEAGVELVE QPVPRANFGA LRRLTEQNGV AILADESLSS
260 270 280 290 300
LSSAFELARD RAVDAFSLKL CNMGGIANTL KVAAIAEAAG ISSYGGTMLD
310 320 330 340 350
STVGTAAALH VYATLPSLPY GCELIGPWVL SDRLTQQDLE IKDFEVHLPV
360 370
GSGLGVDLDH DKVRHYTRAA
Length:370
Mass (Da):39,465
Last modified:March 1, 2004 - v2
Checksum:i195D3101CA18B31C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY078159 Genomic DNA. Translation: AAK57008.2.
AF176244 Genomic DNA. Translation: AAD55083.1.
RefSeqiYP_006961882.1. NC_019283.1.

Genome annotation databases

GeneIDi13918339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY078159 Genomic DNA. Translation: AAK57008.2 .
AF176244 Genomic DNA. Translation: AAD55083.1 .
RefSeqi YP_006961882.1. NC_019283.1.

3D structure databases

ProteinModelPortali Q9RNZ9.
SMRi Q9RNZ9. Positions 1-369.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13918339.

Enzyme and pathway databases

UniPathwayi UPA00083 .

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProi IPR013370. Chloromuconate_cycloisomerase.
IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsi TIGR02534. mucon_cyclo. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A transposon encoding the complete 2,4-dichlorophenoxyacetic acid degradation pathway in the alkalitolerant strain Delftia acidovorans P4a."
    Hoffmann D., Kleinsteuber S., Mueller R.H., Babel W.
    Microbiology 149:2545-2556(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: P4a.
  2. "Development and application of PCR primers for the detection of the tfd genes in Delftia acidovorans P4a involved in the degradation of 2,4-D."
    Hoffmann D., Kleinsteuber S., Mueller R.H., Babel W.
    Acta Biotechnol. 21:321-331(2001)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-268.
    Strain: P4a.
  3. "Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides."
    Mueller R.H., Kleinsteuber S., Babel W.
    Microbiol. Res. 156:121-131(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-263.
    Strain: MC1.
  4. "Regulation of catabolic enzymes during long-term exposure of Delftia acidovorans MC1 to chlorophenoxy herbicides."
    Benndorf D., Davidson I., Babel W.
    Microbiology 150:1005-1014(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-16, INDUCTION BY 2,4-DCPP.
    Strain: MC1.

Entry informationi

Entry nameiTFDD_DELAC
AccessioniPrimary (citable) accession number: Q9RNZ9
Secondary accession number(s): Q93T14, Q9WXC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Different ratios of isoforms are detectable, depending on concentration of dichlorprop.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3