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Q9RNZ9

- TFDD_DELAC

UniProt

Q9RNZ9 - TFDD_DELAC

Protein

Chloromuconate cycloisomerase

Gene

tfdD

Organism
Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei165 – 1651Proton acceptorBy similarity
    Metal bindingi194 – 1941ManganeseBy similarity
    Metal bindingi220 – 2201ManganeseBy similarity
    Metal bindingi245 – 2451ManganeseBy similarity
    Active sitei323 – 3231Proton donorBy similarity

    GO - Molecular functioni

    1. chloromuconate cycloisomerase activity Source: UniProtKB-EC
    2. manganese ion binding Source: InterPro
    3. muconate cycloisomerase activity Source: InterPro

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW
    2. cellular amino acid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00083.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chloromuconate cycloisomerase (EC:5.5.1.7)
    Gene namesi
    Name:tfdD
    OrganismiDelftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
    Taxonomic identifieri80866 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Chloromuconate cycloisomerasePRO_0000171258Add
    BLAST

    Expressioni

    Inductioni

    By 2,4-dichlorophenoxypropionic acid (2,4-DCPP).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RNZ9.
    SMRiQ9RNZ9. Positions 1-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProiIPR013370. Chloromuconate_cycloisomerase.
    IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 1 hit.
    PfamiPF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsiTIGR02534. mucon_cyclo. 1 hit.
    PROSITEiPS00908. MR_MLE_1. 1 hit.
    PS00909. MR_MLE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RNZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIEAISTTI VDVPTRRPLQ MSFTTVHKQS YVIVQVTAGG LVGIGEGGSV    50
    GGPTWGSESA ETIKVIIDNY LAPLLIGKDA SNLSEARALM DRAVTGNLSA 100
    KAAIDIALHD LKARALNLSI ADLIGGTMRK SIPIAWTLAS GDTARDIDSA 150
    LEMIEARRHN RFKVKLGART PAQDLEHIRS IVKAVGDKAS VRVDVNQGWD 200
    EQTASIWIPR LEEAGVELVE QPVPRANFGA LRRLTEQNGV AILADESLSS 250
    LSSAFELARD RAVDAFSLKL CNMGGIANTL KVAAIAEAAG ISSYGGTMLD 300
    STVGTAAALH VYATLPSLPY GCELIGPWVL SDRLTQQDLE IKDFEVHLPV 350
    GSGLGVDLDH DKVRHYTRAA 370
    Length:370
    Mass (Da):39,465
    Last modified:March 1, 2004 - v2
    Checksum:i195D3101CA18B31C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY078159 Genomic DNA. Translation: AAK57008.2.
    AF176244 Genomic DNA. Translation: AAD55083.1.
    RefSeqiYP_006961882.1. NC_019283.1.

    Genome annotation databases

    GeneIDi13918339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY078159 Genomic DNA. Translation: AAK57008.2 .
    AF176244 Genomic DNA. Translation: AAD55083.1 .
    RefSeqi YP_006961882.1. NC_019283.1.

    3D structure databases

    ProteinModelPortali Q9RNZ9.
    SMRi Q9RNZ9. Positions 1-369.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13918339.

    Enzyme and pathway databases

    UniPathwayi UPA00083 .

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProi IPR013370. Chloromuconate_cycloisomerase.
    IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view ]
    PANTHERi PTHR13794. PTHR13794. 1 hit.
    Pfami PF02746. MR_MLE_N. 1 hit.
    [Graphical view ]
    SMARTi SM00922. MR_MLE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsi TIGR02534. mucon_cyclo. 1 hit.
    PROSITEi PS00908. MR_MLE_1. 1 hit.
    PS00909. MR_MLE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A transposon encoding the complete 2,4-dichlorophenoxyacetic acid degradation pathway in the alkalitolerant strain Delftia acidovorans P4a."
      Hoffmann D., Kleinsteuber S., Mueller R.H., Babel W.
      Microbiology 149:2545-2556(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: P4a.
    2. "Development and application of PCR primers for the detection of the tfd genes in Delftia acidovorans P4a involved in the degradation of 2,4-D."
      Hoffmann D., Kleinsteuber S., Mueller R.H., Babel W.
      Acta Biotechnol. 21:321-331(2001)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-268.
      Strain: P4a.
    3. "Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides."
      Mueller R.H., Kleinsteuber S., Babel W.
      Microbiol. Res. 156:121-131(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-263.
      Strain: MC1.
    4. "Regulation of catabolic enzymes during long-term exposure of Delftia acidovorans MC1 to chlorophenoxy herbicides."
      Benndorf D., Davidson I., Babel W.
      Microbiology 150:1005-1014(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-16, INDUCTION BY 2,4-DCPP.
      Strain: MC1.

    Entry informationi

    Entry nameiTFDD_DELAC
    AccessioniPrimary (citable) accession number: Q9RNZ9
    Secondary accession number(s): Q93T14, Q9WXC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Different ratios of isoforms are detectable, depending on concentration of dichlorprop.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3