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Protein

Chloromuconate cycloisomerase

Gene

tfdD

Organism
Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Different ratios of isoforms are detectable, depending on concentration of dichlorprop.

Catalytic activityi

(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate.

Cofactori

Mn2+By similarity

Pathwayi: 3-chlorocatechol degradation

This protein is involved in the pathway 3-chlorocatechol degradation, which is part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway 3-chlorocatechol degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165Proton acceptorBy similarity1
Metal bindingi194ManganeseBy similarity1
Metal bindingi220ManganeseBy similarity1
Metal bindingi245ManganeseBy similarity1
Active sitei323Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAromatic hydrocarbons catabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00083.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloromuconate cycloisomerase (EC:5.5.1.7)
Gene namesi
Name:tfdD
OrganismiDelftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
Taxonomic identifieri80866 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712581 – 370Chloromuconate cycloisomeraseAdd BLAST370

Expressioni

Inductioni

By 2,4-dichlorophenoxypropionic acid (2,4-DCPP).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9RNZ9.
SMRiQ9RNZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd03318. MLE. 1 hit.
Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiView protein in InterPro
IPR013370. Chloromuconate_cycloisomerase.
IPR034390. Enolase-like_superfamily.
IPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
PfamiView protein in Pfam
PF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
SFLDiSFLDG01258. (chloro)muconate_cycloisomeras. 1 hit.
SFLDS00001. Enolase. 1 hit.
SMARTiView protein in SMART
SM00922. MR_MLE. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR02534. mucon_cyclo. 1 hit.
PROSITEiView protein in PROSITE
PS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RNZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEAISTTI VDVPTRRPLQ MSFTTVHKQS YVIVQVTAGG LVGIGEGGSV
60 70 80 90 100
GGPTWGSESA ETIKVIIDNY LAPLLIGKDA SNLSEARALM DRAVTGNLSA
110 120 130 140 150
KAAIDIALHD LKARALNLSI ADLIGGTMRK SIPIAWTLAS GDTARDIDSA
160 170 180 190 200
LEMIEARRHN RFKVKLGART PAQDLEHIRS IVKAVGDKAS VRVDVNQGWD
210 220 230 240 250
EQTASIWIPR LEEAGVELVE QPVPRANFGA LRRLTEQNGV AILADESLSS
260 270 280 290 300
LSSAFELARD RAVDAFSLKL CNMGGIANTL KVAAIAEAAG ISSYGGTMLD
310 320 330 340 350
STVGTAAALH VYATLPSLPY GCELIGPWVL SDRLTQQDLE IKDFEVHLPV
360 370
GSGLGVDLDH DKVRHYTRAA
Length:370
Mass (Da):39,465
Last modified:March 1, 2004 - v2
Checksum:i195D3101CA18B31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078159 Genomic DNA. Translation: AAK57008.2.
AF176244 Genomic DNA. Translation: AAD55083.1.
RefSeqiWP_011255151.1. NC_019283.1.
YP_006961882.1. NC_019283.1.

Genome annotation databases

GeneIDi13918339.
9900895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078159 Genomic DNA. Translation: AAK57008.2.
AF176244 Genomic DNA. Translation: AAD55083.1.
RefSeqiWP_011255151.1. NC_019283.1.
YP_006961882.1. NC_019283.1.

3D structure databases

ProteinModelPortaliQ9RNZ9.
SMRiQ9RNZ9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13918339.
9900895.

Enzyme and pathway databases

UniPathwayiUPA00083.

Family and domain databases

CDDicd03318. MLE. 1 hit.
Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiView protein in InterPro
IPR013370. Chloromuconate_cycloisomerase.
IPR034390. Enolase-like_superfamily.
IPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
PfamiView protein in Pfam
PF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
SFLDiSFLDG01258. (chloro)muconate_cycloisomeras. 1 hit.
SFLDS00001. Enolase. 1 hit.
SMARTiView protein in SMART
SM00922. MR_MLE. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR02534. mucon_cyclo. 1 hit.
PROSITEiView protein in PROSITE
PS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTFDD_DELAC
AccessioniPrimary (citable) accession number: Q9RNZ9
Secondary accession number(s): Q93T14, Q9WXC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: April 12, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.