ID   GLGA_CERS4              Reviewed;         478 AA.
AC   Q9RNH6; Q3J2D8;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 3.
DT   27-MAR-2024, entry version 108.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484};
GN   OrderedLocusNames=RHOS4_14780; ORFNames=RSP_2885;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Igarashi R.Y., Meyer C.R.;
RT   "Cloning, sequencing, and expression of the ADP-glucose pyrophosphorylase
RT   gene (glgC) from Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC
RC   12203 / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD53959.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF181035; AAD53959.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP000143; ABA79046.2; -; Genomic_DNA.
DR   RefSeq; WP_023003625.1; NZ_CP030271.1.
DR   RefSeq; YP_352947.2; NC_007493.2.
DR   AlphaFoldDB; Q9RNH6; -.
DR   SMR; Q9RNH6; -.
DR   STRING; 272943.RSP_2885; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   EnsemblBacteria; ABA79046; ABA79046; RSP_2885.
DR   KEGG; rsp:RSP_2885; -.
DR   PATRIC; fig|272943.9.peg.1821; -.
DR   eggNOG; COG0297; Bacteria.
DR   OrthoDB; 9808590at2; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR   PANTHER; PTHR45825:SF11; STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR   Pfam; PF13692; Glyco_trans_1_4; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..478
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188642"
FT   BINDING         20
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
FT   CONFLICT        97..99
FT                   /note="EGG -> GR (in Ref. 1; AAD53959)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        124..132
FT                   /note="RIAREGLGD -> GSRARGSGT (in Ref. 1; AAD53959)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        190
FT                   /note="E -> K (in Ref. 1; AAD53959)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   478 AA;  50962 MW;  403178D5CBF44F71 CRC64;
     METARGRVLS VASECVPLLK TGGLADVVGA LPGALAAEGW EMRVLMPCYR PLKWRLEEME
     EVFAEEDLFG GPGRVMAGEV AGRKMLLLDA PHLYDREGGP YAGPDGDWGD NAQRFAALSW
     IGARIAREGL GDGWRPDVVH AHDWQAGFTP AYMNYWGSGG ASSVLTVHNI AFQGWAPASL
     LSALRLPPQE FHPAALEYYG GLSSLKAGLV SADHITTVSP TYACELMRPE FGMGLQGVIA
     QRAGQVTGIL NGVDTDIWSP EVEERPYDAE SLKAKAENRA VLSGAFKLSV PGPLAILVSR
     LTYQKGIDLI PEVLPDFIAA GGGLAVLGTG DAPLEAAMRE LEVRFPGRVG VRIGYDEGLS
     HLMFAGGDAV LVPSRFEPCG LTQMYGLRYG AIPVVALTGG LADTIINANP AAMAAGCATG
     LTFHPTEPPA FAEALRRLIH LYADPAAWET VQRNAMRHPV GWETSAAAYA ALYRELVA
//