Reviewed, UniProtKB/Swiss-Prot Q9RND7 (AROA_BORBR)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BB3469

Organism

Bordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

518 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088228
Experimental info
	Sequence conflict	74	1	C → R in AAF01290. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9RND7-1 [UniParc]. Last modified September 19, 2003. Version 2. Checksum: 7690C40EFE62FBBB	FASTA	442	46,576
	10 20 30 40 50 60 MSGLAYLDLP AARLARGEVA LPGSKSISNR VLLLAALAEG STEITGLLDS DDTRVMLAAL 70 80 90 100 110 120 RQLGVSVGEV ADGCVTIEGV ARFPTEQAEL FLGNAGTAFR PLTAALALMG GDYRLSGVPR 130 140 150 160 170 180 MHERPIGDLV DALRQFGAGI EYLGQAGYPP LRIGGGSIRV DGPVRVEGSV SSQFLTALLM 190 200 210 220 230 240 AAPVLARRSG QDITIEVVGE LISKPYIEIT LNLMARFGVS VRRDGWRAFT IARDAAYRGP 250 260 270 280 290 300 GRMAIEGDAS TASYFLALGA IGGGPVRVTG VGEDSIQGDV AFAATLAAMG ADVRYGPGWI 310 320 330 340 350 360 ETRGVRVAEG GRLKAFDADF NLIPDAAMTA ATLALYADGP CRLRNIGSWR VKETDRIHAM 370 380 390 400 410 420 HTELEKLGAG VQSGADWLEV APPAPGGWRD AHIGTWDDHR MAMCFSLAAF GPAAVRILDP 430 440 GCVSKTFPDY FDVYAGLLAA RD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bordetella bronchiseptica aroA." McArthur J.D., Walker M.J. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 240/2.
[2]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RB50 / ATCC BAA-588 / NCTC 13252.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF182427 Genomic DNA. Translation: AAF01290.1. BX640447 Genomic DNA. Translation: CAE33961.1.
RefSeq	NP_890002.1.
3D structure databases
HSSP	HSSP built from PDB template 1G6S based on UniProtKB P07638.
ModBase	Search...
Genome annotation databases
GeneID	2659145.
GenomeReviews	Gene locus BB3469 in contig BX470250_GR.
KEGG	bbr:BB3469.
NMPDR	fig|257310.1.peg.3449.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9RND7.
OMA	EIDTYND.
Enzyme and pathway databases
BioCyc	BBRO257310:BB3469-MON.
BRENDA	2.5.1.19. 413.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BORBR

Accession

Primary (citable) accession number: Q9RND7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	September 19, 2003
Last modified:	November 3, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)