Q9RND7 (AROA_BORBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BB3469

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088228
Experimental info
	Sequence conflict	74	1	C → R in AAF01290. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9RND7 [UniParc]. Last modified September 19, 2003. Version 2. Checksum: 7690C40EFE62FBBB	FASTA	442	46,576
	10 20 30 40 50 60 MSGLAYLDLP AARLARGEVA LPGSKSISNR VLLLAALAEG STEITGLLDS DDTRVMLAAL 70 80 90 100 110 120 RQLGVSVGEV ADGCVTIEGV ARFPTEQAEL FLGNAGTAFR PLTAALALMG GDYRLSGVPR 130 140 150 160 170 180 MHERPIGDLV DALRQFGAGI EYLGQAGYPP LRIGGGSIRV DGPVRVEGSV SSQFLTALLM 190 200 210 220 230 240 AAPVLARRSG QDITIEVVGE LISKPYIEIT LNLMARFGVS VRRDGWRAFT IARDAAYRGP 250 260 270 280 290 300 GRMAIEGDAS TASYFLALGA IGGGPVRVTG VGEDSIQGDV AFAATLAAMG ADVRYGPGWI 310 320 330 340 350 360 ETRGVRVAEG GRLKAFDADF NLIPDAAMTA ATLALYADGP CRLRNIGSWR VKETDRIHAM 370 380 390 400 410 420 HTELEKLGAG VQSGADWLEV APPAPGGWRD AHIGTWDDHR MAMCFSLAAF GPAAVRILDP 430 440 GCVSKTFPDY FDVYAGLLAA RD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bordetella bronchiseptica aroA." McArthur J.D., Walker M.J. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 240/2.
[2]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF182427 Genomic DNA. Translation: AAF01290.1. BX640447 Genomic DNA. Translation: CAE33961.1.
RefSeq	NP_890002.1. NC_002927.3.
3D structure databases
ProteinModelPortal	Q9RND7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2659145.
GenomeReviews	Gene locus BB3469 in contig BX470250_GR.
KEGG	bbr:BB3469.
NMPDR	fig|257310.1.peg.3449.
PATRIC	21140367. VBIBorBro124907_3543.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	Q9RND7.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BBRO257310:BB3469-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BORBR

Accession

Primary (citable) accession number: Q9RND7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	September 19, 2003
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program