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Protein

Type IV secretion system protein VirB6

Gene

virB6

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent VirB-independent mitogenic activity. These changes of HEC require the T4S coupling protein VirD4 and at least one of the effector proteins BepA-G.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport, Virulence

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1325-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein VirB6
Gene namesi
Name:virB6
Ordered Locus Names:BH13300
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Type IV secretion system protein VirB6PRO_0000273530Add
BLAST

Proteomic databases

PaxDbiQ9RND2.

Expressioni

Inductioni

During the interaction with the intracellular environment of host cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi283166.BH13300.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrbL/VirB6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3704. LUCA.
HOGENOMiHOG000000505.
KOiK03201.
OMAiMFAQVAL.
OrthoDBiEOG64FK96.

Family and domain databases

InterProiIPR007688. Conjugal_tfr_TrbL/VirB6.
[Graphical view]
PfamiPF04610. TrbL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RND2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFSFSPFE SISGYILQPL NNVMNTTVSG LSSAISAPLN LASIIFIFLY
60 70 80 90 100
GYNVMTGRVA LSMNSLLNNV VKIVIVTTMA TNADTFNTYV KNIFFGDLAN
110 120 130 140 150
AIGNALNSNP SSANVFDYIL LKTSARYQEV LAAAWFLEKI MVGLLGSLMI
160 170 180 190 200
MAVIVFCIGG FIVQMFAQVA LVMIIGLGPL FISLYLFNAT RKFTDAWITT
210 220 230 240 250
LVNFTILQVL VIMLGTIMCK IILYVLDGTY ESIYFLFPPV VVISIVGAIL
260 270 280 290 300
FRALPGIASA LSSGGPYFNA GISSGGQIFT MLSSGAKTGR NAAKSAASTL
310 320
SGAAGTATKA AKIGGNGRGR F
Length:321
Mass (Da):34,083
Last modified:May 1, 2000 - v1
Checksum:iE40AB18EA8743577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182718 Genomic DNA. Translation: AAF00944.1.
BX897699 Genomic DNA. Translation: CAF28103.1.
RefSeqiWP_011181131.1. NZ_LRIJ01000002.1.

Genome annotation databases

EnsemblBacteriaiCAF28103; CAF28103; BH13300.
KEGGibhe:BH13300.
PATRICi20546661. VBIBarHen29080_1450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182718 Genomic DNA. Translation: AAF00944.1.
BX897699 Genomic DNA. Translation: CAF28103.1.
RefSeqiWP_011181131.1. NZ_LRIJ01000002.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283166.BH13300.

Proteomic databases

PaxDbiQ9RND2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF28103; CAF28103; BH13300.
KEGGibhe:BH13300.
PATRICi20546661. VBIBarHen29080_1450.

Phylogenomic databases

eggNOGiCOG3704. LUCA.
HOGENOMiHOG000000505.
KOiK03201.
OMAiMFAQVAL.
OrthoDBiEOG64FK96.

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1325-MONOMER.

Family and domain databases

InterProiIPR007688. Conjugal_tfr_TrbL/VirB6.
[Graphical view]
PfamiPF04610. TrbL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene encoding the 17-kDa antigen of Bartonella henselae is located within a cluster of genes homologous to the virB virulence operon."
    Padmalayam I., Karem K., Baumstark B.R., Massung R.
    DNA Cell Biol. 19:377-382(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49882 / DSM 28221 / Houston 1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / DSM 28221 / Houston 1.
  3. "Intracellular induction of the Bartonella henselae virB operon by human endothelial cells."
    Schmiederer M., Arcenas R., Widen R., Valkov N., Anderson B.E.
    Infect. Immun. 69:6495-6502(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 49882 / DSM 28221 / Houston 1.
  4. "The VirB type IV secretion system of Bartonella henselae mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells."
    Schmid M.C., Schulein R., Dehio M., Denecker G., Carena I., Dehio C.
    Mol. Microbiol. 52:81-92(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: ATCC 49882 / DSM 28221 / Houston 1.
  5. "A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells."
    Schulein R., Guye P., Rhomberg T.A., Schmid M.C., Schroeder G., Vergunst A.C., Carena I., Dehio C.
    Proc. Natl. Acad. Sci. U.S.A. 102:856-861(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: ATCC 49882 / DSM 28221 / Houston 1.

Entry informationi

Entry nameiVIRB6_BARHE
AccessioniPrimary (citable) accession number: Q9RND2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.