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Protein

Type IV secretion system protein VirB6

Gene

virB6

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent VirB-independent mitogenic activity. These changes of HEC require the T4S coupling protein VirD4 and at least one of the effector proteins BepA-G.2 Publications

GO - Biological processi

Keywordsi

Biological processTransport, Virulence

Enzyme and pathway databases

BioCyciBHEN283166:G1GJ7-1357-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein VirB6
Gene namesi
Name:virB6
Ordered Locus Names:BH13300
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002735301 – 321Type IV secretion system protein VirB6Add BLAST321

Proteomic databases

PaxDbiQ9RND2

Expressioni

Inductioni

During the interaction with the intracellular environment of host cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi283166.BH13300

Family & Domainsi

Sequence similaritiesi

Belongs to the TrbL/VirB6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3704 LUCA
HOGENOMiHOG000000505
KOiK03201
OMAiMFAQVAL
OrthoDBiPOG091H0ND6

Family and domain databases

InterProiView protein in InterPro
IPR007688 Conjugal_tfr_TrbL/VirB6
PfamiView protein in Pfam
PF04610 TrbL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RND2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFSFSPFE SISGYILQPL NNVMNTTVSG LSSAISAPLN LASIIFIFLY
60 70 80 90 100
GYNVMTGRVA LSMNSLLNNV VKIVIVTTMA TNADTFNTYV KNIFFGDLAN
110 120 130 140 150
AIGNALNSNP SSANVFDYIL LKTSARYQEV LAAAWFLEKI MVGLLGSLMI
160 170 180 190 200
MAVIVFCIGG FIVQMFAQVA LVMIIGLGPL FISLYLFNAT RKFTDAWITT
210 220 230 240 250
LVNFTILQVL VIMLGTIMCK IILYVLDGTY ESIYFLFPPV VVISIVGAIL
260 270 280 290 300
FRALPGIASA LSSGGPYFNA GISSGGQIFT MLSSGAKTGR NAAKSAASTL
310 320
SGAAGTATKA AKIGGNGRGR F
Length:321
Mass (Da):34,083
Last modified:May 1, 2000 - v1
Checksum:iE40AB18EA8743577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182718 Genomic DNA Translation: AAF00944.1
BX897699 Genomic DNA Translation: CAF28103.1
RefSeqiWP_011181131.1, NZ_LRIJ02000001.1

Genome annotation databases

EnsemblBacteriaiCAF28103; CAF28103; BH13300
GeneIDi29621468
KEGGibhe:BH13300

Similar proteinsi

Entry informationi

Entry nameiVIRB6_BARHE
AccessioniPrimary (citable) accession number: Q9RND2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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