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Protein

Nine-heme cytochrome c

Gene

Ddes_2038

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May form part of a transmembrane redox complex through which electrons are transferred to the cytoplasm for reduction of sulfate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron (heme 1 axial ligand)1
Metal bindingi70Iron (heme 3 axial ligand)1
Binding sitei77Heme 1 (covalent)1
Binding sitei80Heme 1 (covalent)1
Metal bindingi81Iron (heme 1 axial ligand)1
Metal bindingi82Iron (heme 2 axial ligand)1
Binding sitei89Heme 2 (covalent)1
Binding sitei92Heme 2 (covalent)1
Metal bindingi93Iron (heme 2 axial ligand)1
Metal bindingi111Iron (heme 5 axial ligand)1
Binding sitei127Heme 3 (covalent)1
Binding sitei130Heme 3 (covalent)1
Metal bindingi131Iron (heme 3 axial ligand)1
Binding sitei141Heme 4 (covalent)1
Binding sitei144Heme 4 (covalent)1
Metal bindingi145Iron (heme 4 axial ligand)1
Binding sitei157Heme 5 (covalent)1
Binding sitei160Heme 5 (covalent)1
Metal bindingi161Iron (heme 5 axial ligand)1
Metal bindingi227Iron (heme 6 axial ligand)1
Metal bindingi230Iron (heme 8 axial ligand)1
Metal bindingi248Iron (heme 4 axial ligand)1
Binding sitei255Heme 6 (covalent)1
Binding sitei258Heme 6 (covalent)1
Metal bindingi259Iron (heme 6 axial ligand)1
Metal bindingi260Iron (heme 7 axial ligand)1
Binding sitei271Heme 7 (covalent)1
Binding sitei274Heme 7 (covalent)1
Metal bindingi275Iron (heme 7 axial ligand)1
Metal bindingi294Iron (heme 9 axial ligand)1
Binding sitei297Heme 8 (covalent)1
Binding sitei300Heme 8 (covalent)1
Metal bindingi301Iron (heme 8 axial ligand)1
Binding sitei314Heme 9 (covalent)1
Binding sitei317Heme 9 (covalent)1
Metal bindingi318Iron (heme 9 axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciDDES525146:GIWF-2079-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nine-heme cytochrome c
Alternative name(s):
9Hcc
Gene namesi
Ordered Locus Names:Ddes_2038
OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Taxonomic identifieri525146 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002598 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Add BLAST30
ChainiPRO_000000659431 – 326Nine-heme cytochrome cAdd BLAST296

Post-translational modificationi

Binds 9 heme groups per subunit.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi525146.Ddes_2038.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 40Combined sources4
Beta strandi42 – 46Combined sources5
Beta strandi63 – 66Combined sources4
Helixi67 – 73Combined sources7
Helixi77 – 80Combined sources4
Helixi89 – 91Combined sources3
Helixi99 – 101Combined sources3
Helixi106 – 111Combined sources6
Beta strandi119 – 121Combined sources3
Helixi127 – 137Combined sources11
Helixi139 – 142Combined sources4
Helixi144 – 147Combined sources4
Helixi154 – 160Combined sources7
Helixi169 – 177Combined sources9
Helixi182 – 194Combined sources13
Helixi204 – 206Combined sources3
Beta strandi211 – 213Combined sources3
Beta strandi218 – 220Combined sources3
Beta strandi223 – 225Combined sources3
Helixi227 – 236Combined sources10
Turni237 – 240Combined sources4
Helixi242 – 247Combined sources6
Helixi253 – 257Combined sources5
Helixi271 – 273Combined sources3
Helixi289 – 303Combined sources15
Beta strandi314 – 318Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
19HCX-ray1.80A/B31-321[»]
1OFWX-ray1.50A/B31-326[»]
1OFYX-ray2.00A/B31-326[»]
ProteinModelPortaliQ9RN68.
SMRiQ9RN68.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RN68.

Family & Domainsi

Domaini

Arranged into two tetraheme clusters and the extra heme 4 is located asymmetrically between the two regions.

Sequence similaritiesi

Contains 9 cytochrome c domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105F1C. Bacteria.
ENOG410XRT9. LUCA.
OrthoDBiPOG091H0RGX.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 2 hits.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RN68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNGTSLLLL AAIALAGAAC LTAMGGTAKA AALEPTDSGA PSAIVMFPVG
60 70 80 90 100
EKPNPKGAAM KPVVFNHLIH EKKIDNCETC HHTGDPVSCS TCHTVEGKAE
110 120 130 140 150
GNYITLDRAM HATNIAKRAK GNTPVSCVSC HEQQTKERRE CAGCHAIVTP
160 170 180 190 200
KRDEAWCATC HNITPSMTPE QMQKGINGTL LPGDNEALAA ETVLAQKTVE
210 220 230 240 250
PVSPMLAPYK VVIDALADKY EPSNFTHRRH LTSLMERIKD DKLAQAFHNK
260 270 280 290 300
PEILCATCHH RSPLSLTPPK CGSCHTKEID KANPGRPNLM AAYHLQCMGC
310 320
HKGMDVARPR DTDCTTCHKA APKSAD
Length:326
Mass (Da):35,025
Last modified:May 1, 2000 - v1
Checksum:i2ED7025ADDF250E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186393 Genomic DNA. Translation: AAD56586.1.
CP001358 Genomic DNA. Translation: ACL49934.1.
PIRiJC7094.
RefSeqiWP_012625658.1. NC_011883.1.

Genome annotation databases

EnsemblBacteriaiACL49934; ACL49934; Ddes_2038.
KEGGidds:Ddes_2038.
PATRICi21738090. VBIDesDes50650_2377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186393 Genomic DNA. Translation: AAD56586.1.
CP001358 Genomic DNA. Translation: ACL49934.1.
PIRiJC7094.
RefSeqiWP_012625658.1. NC_011883.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
19HCX-ray1.80A/B31-321[»]
1OFWX-ray1.50A/B31-326[»]
1OFYX-ray2.00A/B31-326[»]
ProteinModelPortaliQ9RN68.
SMRiQ9RN68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi525146.Ddes_2038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL49934; ACL49934; Ddes_2038.
KEGGidds:Ddes_2038.
PATRICi21738090. VBIDesDes50650_2377.

Phylogenomic databases

eggNOGiENOG4105F1C. Bacteria.
ENOG410XRT9. LUCA.
OrthoDBiPOG091H0RGX.

Enzyme and pathway databases

BioCyciDDES525146:GIWF-2079-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9RN68.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 2 hits.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC9_DESDA
AccessioniPrimary (citable) accession number: Q9RN68
Secondary accession number(s): B8J3C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.