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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciXNEM406817:GHY4-1443-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:XNC1_1437
OrganismiXenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Taxonomic identifieri406817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus
ProteomesiUP000008075: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3283286-phosphogluconolactonasePRO_0000171141Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9RMP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257418.
KOiK07404.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RMP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQVVYTASP NSRQIHVWSL NVEGGLSLLQ TVDVPGEVQP MVINPDGKHL
60 70 80 90 100
YVGIRPQFSI VTYAIGKNGS LEQKSIAPLP GSPTHISTDR AGRFLFSASY
110 120 130 140 150
SFNNLSVHPI DDQGNVKAPI QIVENLQAPH SANIDRENRQ LLVPCLKEDH
160 170 180 190 200
IRIFNMDNQG YLVESHADAI TTETGAGPRH MAFHPKKQAI YCINELDSTV
210 220 230 240 250
DVLRKWEKYR IVQSVDSLPA DFSSVRWSAD IHMTPDGRHL YTSERSESLI
260 270 280 290 300
SHFRVSEEGY HLTLAGHYLT ETQPRGFAID HSGHFLIASG QKSDHISVSR
310 320
IDKFSGELTQ LARYPVGKSP MWVTILAL
Length:328
Mass (Da):36,600
Last modified:June 15, 2010 - v2
Checksum:i9F52F5F67DFADF92
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271W → C in AAF04393. (PubMed:10742251)Curated
Sequence conflicti258 – 2581E → G in AAF04393. (PubMed:10742251)Curated
Sequence conflicti265 – 2651A → T in AAF04393. (PubMed:10742251)Curated
Sequence conflicti273 – 2808QPRGFAID → NPVALPLI in AAF04393. (PubMed:10742251)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667742 Genomic DNA. Translation: CBJ89500.1.
AF191556 Genomic DNA. Translation: AAF04393.1.
RefSeqiYP_003711700.1. NC_014228.1.

Genome annotation databases

EnsemblBacteriaiCBJ89500; CBJ89500; XNC1_1437.
GeneIDi9430193.
KEGGixne:XNC1_1437.
PATRICi42462698. VBIXenNem38452_1323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667742 Genomic DNA. Translation: CBJ89500.1.
AF191556 Genomic DNA. Translation: AAF04393.1.
RefSeqiYP_003711700.1. NC_014228.1.

3D structure databases

ProteinModelPortaliQ9RMP7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBJ89500; CBJ89500; XNC1_1437.
GeneIDi9430193.
KEGGixne:XNC1_1437.
PATRICi42462698. VBIXenNem38452_1323.

Phylogenomic databases

HOGENOMiHOG000257418.
KOiK07404.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciXNEM406817:GHY4-1443-MONOMER.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
    Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6.
  2. "Inactivation of a novel gene produces a phenotypic variant cell and affects the symbiotic behavior of Xenorhabdus nematophilus."
    Volgyi A., Fodor A., Forst S.
    Appl. Environ. Microbiol. 66:1622-1628(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-328.
    Strain: ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6.

Entry informationi

Entry namei6PGL_XENNA
AccessioniPrimary (citable) accession number: Q9RMP7
Secondary accession number(s): D3VAR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 15, 2010
Last modified: January 7, 2015
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.