Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:XNC1_1437
OrganismiXenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Taxonomic identifieri406817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeXenorhabdus
Proteomesi
  • UP000008075 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001711411 – 3286-phosphogluconolactonaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi406817.XNC1_1437

Structurei

3D structure databases

ProteinModelPortaliQ9RMP7
SMRiQ9RMP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RMP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVVYTASP NSRQIHVWSL NVEGGLSLLQ TVDVPGEVQP MVINPDGKHL
60 70 80 90 100
YVGIRPQFSI VTYAIGKNGS LEQKSIAPLP GSPTHISTDR AGRFLFSASY
110 120 130 140 150
SFNNLSVHPI DDQGNVKAPI QIVENLQAPH SANIDRENRQ LLVPCLKEDH
160 170 180 190 200
IRIFNMDNQG YLVESHADAI TTETGAGPRH MAFHPKKQAI YCINELDSTV
210 220 230 240 250
DVLRKWEKYR IVQSVDSLPA DFSSVRWSAD IHMTPDGRHL YTSERSESLI
260 270 280 290 300
SHFRVSEEGY HLTLAGHYLT ETQPRGFAID HSGHFLIASG QKSDHISVSR
310 320
IDKFSGELTQ LARYPVGKSP MWVTILAL
Length:328
Mass (Da):36,600
Last modified:June 15, 2010 - v2
Checksum:i9F52F5F67DFADF92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227W → C in AAF04393 (PubMed:10742251).Curated1
Sequence conflicti258E → G in AAF04393 (PubMed:10742251).Curated1
Sequence conflicti265A → T in AAF04393 (PubMed:10742251).Curated1
Sequence conflicti273 – 280QPRGFAID → NPVALPLI in AAF04393 (PubMed:10742251).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667742 Genomic DNA Translation: CBJ89500.1
AF191556 Genomic DNA Translation: AAF04393.1
RefSeqiWP_010848273.1, NC_014228.1

Genome annotation databases

EnsemblBacteriaiCBJ89500; CBJ89500; XNC1_1437
KEGGixne:XNC1_1437

Similar proteinsi

Entry informationi

Entry namei6PGL_XENNA
AccessioniPrimary (citable) accession number: Q9RMP7
Secondary accession number(s): D3VAR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health