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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Acinetobacter lwoffii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei361Proton donorBy similarity1
Active sitei392By similarity1
Active sitei520By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
OrganismiAcinetobacter lwoffii
Taxonomic identifieri28090 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805791 – 557Glucose-6-phosphate isomeraseAdd BLAST557

Structurei

3D structure databases

ProteinModelPortaliQ9RMC1.
SMRiQ9RMC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RMC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYKQPLIVK SQQQALSALR NLKMQTQDTH LNQFFSDDSG RFERFSVEQE
60 70 80 90 100
QLVLDFSKHR IDQNVLNGLV DLAHAQDLTQ WIQRLFSLEE INYTEQRAAM
110 120 130 140 150
HWALRVPEQN QQVLPEITAQ VHTQLERMYS LVEKIHAGQY RGATGEVIQD
160 170 180 190 200
VVNIGVGGSD LGPLMVTHAL SDFKVVTAKP LDVHFVSTMD GSQLSDLLHQ
210 220 230 240 250
LRPETTLFII SSKSFGTIDT LSNAQTVRQW LEKALGKNSH VLKHHFIGVS
260 270 280 290 300
TKPDKMSEWG IAPENQLLLW DWVGGRYSLW SCIGLPIALT VGVDGFKQLL
310 320 330 340 350
SGAYAIDQHF QTAPFAQNIP VLIGLLGVWN NNFLDIQTHA VLPYDGRLKY
360 370 380 390 400
FAAYLQQLEM ESNGKSTQRS GEKVDSATCP IVWGEVGPNA QHAFYQLLHQ
410 420 430 440 450
GTHKVSCDFI APVKRYNANH FTYAENAEAL IEQHHLALSN CLAQSRLLAF
460 470 480 490 500
GNQALTADEI EDLPTYKQYE GNQPSSTILL KELNPYSLGM LIATYEHKVF
510 520 530 540 550
VQSVLWNINP FDQWGVEKGK EIANQLLPIL NREQDDLSTF DASTQGLLKI

LLGKNNG
Length:557
Mass (Da):62,671
Last modified:May 1, 2000 - v1
Checksum:i2D4FABC1AB595D26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243431 Genomic DNA. Translation: CAB57211.1.
PIRiT44843.

Similar proteinsi

Entry informationi

Entry nameiG6PI_ACILW
AccessioniPrimary (citable) accession number: Q9RMC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families