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Protein

Protein CitXG

Gene

citXG

Organism
Weissella paramesenteroides (Leuconostoc paramesenteroides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein.By similarity

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo-[acyl-carrier protein] + diphosphate.
ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. holo-citrate lyase synthase activity Source: UniProtKB-EC
  3. triphosphoribosyl-dephospho-CoA synthase activity Source: InterPro

GO - Biological processi

  1. phosphorylation Source: InterPro
  2. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CitXG
Including the following 2 domains:
Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
Gene namesi
Name:citXG
Synonyms:citG
Encoded oniPlasmid pCITJ10 Publication
OrganismiWeissella paramesenteroides (Leuconostoc paramesenteroides)
Taxonomic identifieri1249 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Protein CitXGPRO_0000214684Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 178178Apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseAdd
BLAST
Regioni179 – 4622842-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the CitX family.Curated
In the C-terminal section; belongs to the CitG/MdcB family.Curated

Family and domain databases

HAMAPiMF_00397. CitG.
MF_00398. CitX.
InterProiIPR002736. CitG.
IPR005551. CitX.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
PF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
TIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RLT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIFDIGEAV DLLTVLDNRE WRSRLQDKLK VTNSDKIVIS AKLNIPGPIK
60 70 80 90 100
NNDILQKIFM DGWQTFVAGF ECNSQYEMLF AERATGPEAF ITVDGNLAAV
110 120 130 140 150
KKTAILFEET YALGRLFDID VMANGQADYQ LSREDLGFGP RLCLICGKPA
160 170 180 190 200
KVCAKEQNHT LDEGYEVINQ MYQGATSKEL IFEKESQETV VNNALKGLLY
210 220 230 240 250
EVSLNPKPGL VDPVSMGSHT DMNMFMFIDS SLSLKSYLDK AFKLGRNFEG
260 270 280 290 300
SDLKLLFNAL RAEGVLAEQT MFNATNNANT HKGAIFSLGI WVTAIAYSTK
310 320 330 340 350
DGSATMTEVR RVIQRMVEGL IEKDLASNRV ATTAGEQQFQ TYQLTGIRGE
360 370 380 390 400
AVNGFPGVSE VAVPFLQATF GTMTQRLLDT LMKIAATLED STLIKRAKTP
410 420 430 440 450
DVLAEMKEWT SIYFKLGGSH TEQGMKYLYD LDRLFIERNL SIGGSADTLI
460
LTIFIGQLTG LL
Length:462
Mass (Da):51,206
Last modified:May 1, 2000 - v1
Checksum:i1302B481521FC4A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132782 Genomic DNA. Translation: CAB60044.1.
PIRiT46732.
RefSeqiWP_032491422.1. NG_036112.1.
YP_009080062.1. NG_036112.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132782 Genomic DNA. Translation: CAB60044.1.
PIRiT46732.
RefSeqiWP_032491422.1. NG_036112.1.
YP_009080062.1. NG_036112.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_00397. CitG.
MF_00398. CitX.
InterProiIPR002736. CitG.
IPR005551. CitX.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
PF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
TIGR03124. citrate_citX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and molecular characterization of the citrate utilization citMCDEFGRP cluster of Leuconostoc paramesenteroides."
    Martin M., Corrales M., de Mendoza D., Lopez P., Magni C.
    FEMS Microbiol. Lett. 174:231-238(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: J1.

Entry informationi

Entry nameiCITXG_WEIPA
AccessioniPrimary (citable) accession number: Q9RLT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.