Reviewed, UniProtKB/Swiss-Prot Q9RLM4 (MTD1_NEIMC)

Names and origin

Protein names

Recommended name:
    Probable modification methylase NmeDIP
      Short name=M.NmeDIP
    EC=2.1.1.37
Alternative name(s):
    Cytosine-specific methyltransferase NmeDIP

Gene names

Name:

nmeDIMP

Organism

Neisseria meningitidis serogroup C

Taxonomic identifier

135720 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This methylase recognizes a double-stranded sequence, causes specific methylation on a C on both strands, and protects the DNA from cleavage by the NmeDIP endonuclease By similarity.
Catalytic activity	S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
Sequence similarities	Belongs to the C5-methyltransferase family.

Ontologies

Keywords
Biological process	Restriction system
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	DNA methylation Inferred from electronic annotation. Source: InterPro DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA (cytosine-5-)-methyltransferase activity Inferred from electronic annotation. Source: EC DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Probable modification methylase NmeDIP		PRO_0000087902
Sites
	Active site	148	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RLM4-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6E2472BA070354C9	FASTA	420	47,931
	10 20 30 40 50 60 MMSLKIQPAV PKKSDKPSAT NRDCQNFKRE KNNLPFQLTD KSCNLDISIR QERKKTLIFS 70 80 90 100 110 120 FFSGAGFLDL GFELSGFDIA FVNEVHPPFL EAYKYSRSRM DIPKPKYGYF KGSIDECLYA 130 140 150 160 170 180 EKAKDLAGWV KKEKQNGIIV GFIGGPPCPD FSIAGKNKGK DGENGKLSQS YVDLICKNQP 190 200 210 220 230 240 DFFVFENVKG LYRTAKHREF FNALKRQLSD FGYVCTEKLI NAIEYGVPQD RERIILVGFL 250 260 270 280 290 300 SQHVDALQKF DWDAHISFPD ALEKDWPTTE EVGRVVSQPA NIYPELTVQY WFNRNGVDTH 310 320 330 340 350 360 PNASKHFQPR AGLEKFQTIS EGDDKKKSYK RLHRWRYSPT AAYGNNEVHI HPYLPRRISA 370 380 390 400 410 420 AEALAIQSLP KEFELPDNMT LSNMFKTIGN GVPFLAAKGI AMTLKSYLEN HYERTKTDGC

References

[1]

"Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis." Claus H., Friedrich A., Frosch M., Vogel U. J. Bacteriol. 182:1296-1303(2000) [PubMed: 10671450] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 2120 / Serogroup C / Serotype NT.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238948 Genomic DNA. Translation: CAB59897.1.
3D structure databases
HSSP	HSSP built from PDB template 1DCT based on UniProtKB P20589.
ModBase	Search...
Protein family/group databases
REBASE	4188. M.NmeDI.
Enzyme and pathway databases
BRENDA	2.1.1.37. 298707.
Family and domain databases
InterPro	IPR001525. C5_DNA_meth. IPR018117. C5_DNA_meth_AS. [Graphical view]
PANTHER	PTHR10629. C5_DNA_meth. 1 hit.
Pfam	PF00145. DNA_methylase. 2 hits. [Graphical view]
PRINTS	PR00105. C5METTRFRASE.
TIGRFAMs	TIGR00675. dcm. 1 hit.
PROSITE	PS00094. C5_MTASE_1. False negative. PS00095. C5_MTASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTD1_NEIMC

Accession

Primary (citable) accession number: Q9RLM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	March 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)