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Q9RLM4

- MTD1_NEIMC

UniProt

Q9RLM4 - MTD1_NEIMC

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Protein
Probable modification methylase NmeDIP
Gene
nmeDIMP
Organism
Neisseria meningitidis serogroup C
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes a double-stranded sequence, causes specific methylation on a C on both strands, and protects the DNA from cleavage by the NmeDIP endonuclease By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi4188. M.NmeDI.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable modification methylase NmeDIP (EC:2.1.1.37)
Short name:
M.NmeDIP
Alternative name(s):
Cytosine-specific methyltransferase NmeDIP
Gene namesi
Name:nmeDIMP
OrganismiNeisseria meningitidis serogroup C
Taxonomic identifieri135720 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Probable modification methylase NmeDIP
PRO_0000087902Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9RLM4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 411356SAM-dependent MTase C5-type
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RLM4-1 [UniParc]FASTAAdd to Basket

« Hide

MMSLKIQPAV PKKSDKPSAT NRDCQNFKRE KNNLPFQLTD KSCNLDISIR    50
QERKKTLIFS FFSGAGFLDL GFELSGFDIA FVNEVHPPFL EAYKYSRSRM 100
DIPKPKYGYF KGSIDECLYA EKAKDLAGWV KKEKQNGIIV GFIGGPPCPD 150
FSIAGKNKGK DGENGKLSQS YVDLICKNQP DFFVFENVKG LYRTAKHREF 200
FNALKRQLSD FGYVCTEKLI NAIEYGVPQD RERIILVGFL SQHVDALQKF 250
DWDAHISFPD ALEKDWPTTE EVGRVVSQPA NIYPELTVQY WFNRNGVDTH 300
PNASKHFQPR AGLEKFQTIS EGDDKKKSYK RLHRWRYSPT AAYGNNEVHI 350
HPYLPRRISA AEALAIQSLP KEFELPDNMT LSNMFKTIGN GVPFLAAKGI 400
AMTLKSYLEN HYERTKTDGC 420
Length:420
Mass (Da):47,931
Last modified:May 1, 2000 - v1
Checksum:i6E2472BA070354C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238948 Genomic DNA. Translation: CAB59897.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238948 Genomic DNA. Translation: CAB59897.1 .

3D structure databases

ProteinModelPortali Q9RLM4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 4188. M.NmeDI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis."
    Claus H., Friedrich A., Frosch M., Vogel U.
    J. Bacteriol. 182:1296-1303(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2120 / Serogroup C / Serotype NT.

Entry informationi

Entry nameiMTD1_NEIMC
AccessioniPrimary (citable) accession number: Q9RLM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi