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Q9RLM4 (MTD1_NEIMC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable modification methylase NmeDIP

Short name=M.NmeDIP
EC=2.1.1.37
Alternative name(s):
Cytosine-specific methyltransferase NmeDIP
Gene names
Name:nmeDIMP
OrganismNeisseria meningitidis serogroup C
Taxonomic identifier135720 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes a double-stranded sequence, causes specific methylation on a C on both strands, and protects the DNA from cleavage by the NmeDIP endonuclease By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 1 SAM-dependent MTase C5-type domain.

Ontologies

Keywords
   Biological processRestriction system
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA (cytosine-5-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Probable modification methylase NmeDIP
PRO_0000087902

Regions

Domain56 – 411356SAM-dependent MTase C5-type

Sites

Active site1481 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RLM4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 6E2472BA070354C9

FASTA42047,931
        10         20         30         40         50         60 
MMSLKIQPAV PKKSDKPSAT NRDCQNFKRE KNNLPFQLTD KSCNLDISIR QERKKTLIFS 

        70         80         90        100        110        120 
FFSGAGFLDL GFELSGFDIA FVNEVHPPFL EAYKYSRSRM DIPKPKYGYF KGSIDECLYA 

       130        140        150        160        170        180 
EKAKDLAGWV KKEKQNGIIV GFIGGPPCPD FSIAGKNKGK DGENGKLSQS YVDLICKNQP 

       190        200        210        220        230        240 
DFFVFENVKG LYRTAKHREF FNALKRQLSD FGYVCTEKLI NAIEYGVPQD RERIILVGFL 

       250        260        270        280        290        300 
SQHVDALQKF DWDAHISFPD ALEKDWPTTE EVGRVVSQPA NIYPELTVQY WFNRNGVDTH 

       310        320        330        340        350        360 
PNASKHFQPR AGLEKFQTIS EGDDKKKSYK RLHRWRYSPT AAYGNNEVHI HPYLPRRISA 

       370        380        390        400        410        420 
AEALAIQSLP KEFELPDNMT LSNMFKTIGN GVPFLAAKGI AMTLKSYLEN HYERTKTDGC 

« Hide

References

[1]"Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis."
Claus H., Friedrich A., Frosch M., Vogel U.
J. Bacteriol. 182:1296-1303(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 2120 / Serogroup C / Serotype NT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ238948 Genomic DNA. Translation: CAB59897.1.

3D structure databases

ProteinModelPortalQ9RLM4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE4188. M.NmeDI.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSPR00105. C5METTRFRASE.
SUPFAMSSF53335. SSF53335. 1 hit.
TIGRFAMsTIGR00675. dcm. 1 hit.
PROSITEPS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTD1_NEIMC
AccessionPrimary (citable) accession number: Q9RLM4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries