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Q9RLM4

- MTD1_NEIMC

UniProt

Q9RLM4 - MTD1_NEIMC

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Protein

Probable modification methylase NmeDIP

Gene

nmeDIMP

Organism
Neisseria meningitidis serogroup C
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes a double-stranded sequence, causes specific methylation on a C on both strands, and protects the DNA from cleavage by the NmeDIP endonuclease.By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi4188. M.NmeDI.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable modification methylase NmeDIP (EC:2.1.1.37)
Short name:
M.NmeDIP
Alternative name(s):
Cytosine-specific methyltransferase NmeDIP
Gene namesi
Name:nmeDIMP
OrganismiNeisseria meningitidis serogroup C
Taxonomic identifieri135720 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Probable modification methylase NmeDIPPRO_0000087902Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9RLM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 411356SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RLM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSLKIQPAV PKKSDKPSAT NRDCQNFKRE KNNLPFQLTD KSCNLDISIR
60 70 80 90 100
QERKKTLIFS FFSGAGFLDL GFELSGFDIA FVNEVHPPFL EAYKYSRSRM
110 120 130 140 150
DIPKPKYGYF KGSIDECLYA EKAKDLAGWV KKEKQNGIIV GFIGGPPCPD
160 170 180 190 200
FSIAGKNKGK DGENGKLSQS YVDLICKNQP DFFVFENVKG LYRTAKHREF
210 220 230 240 250
FNALKRQLSD FGYVCTEKLI NAIEYGVPQD RERIILVGFL SQHVDALQKF
260 270 280 290 300
DWDAHISFPD ALEKDWPTTE EVGRVVSQPA NIYPELTVQY WFNRNGVDTH
310 320 330 340 350
PNASKHFQPR AGLEKFQTIS EGDDKKKSYK RLHRWRYSPT AAYGNNEVHI
360 370 380 390 400
HPYLPRRISA AEALAIQSLP KEFELPDNMT LSNMFKTIGN GVPFLAAKGI
410 420
AMTLKSYLEN HYERTKTDGC
Length:420
Mass (Da):47,931
Last modified:May 1, 2000 - v1
Checksum:i6E2472BA070354C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238948 Genomic DNA. Translation: CAB59897.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238948 Genomic DNA. Translation: CAB59897.1 .

3D structure databases

ProteinModelPortali Q9RLM4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 4188. M.NmeDI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis."
    Claus H., Friedrich A., Frosch M., Vogel U.
    J. Bacteriol. 182:1296-1303(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2120 / Serogroup C / Serotype NT.

Entry informationi

Entry nameiMTD1_NEIMC
AccessioniPrimary (citable) accession number: Q9RLM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3