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Q9RKU5

- ALLB_STRCO

UniProt

Q9RKU5 - ALLB_STRCO

Protein

Allantoinase

Gene

allB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi63 – 631Zinc 1UniRule annotation
    Metal bindingi65 – 651Zinc 1UniRule annotation
    Metal bindingi150 – 1501Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi150 – 1501Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi186 – 1861Zinc 2UniRule annotation
    Metal bindingi238 – 2381Zinc 2UniRule annotation
    Metal bindingi311 – 3111Zinc 1UniRule annotation

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-HAMAP
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
    Alternative name(s):
    Allantoin-utilizing enzymeUniRule annotation
    Gene namesi
    Name:allBUniRule annotation
    Ordered Locus Names:SCO6247
    ORF Names:SCAH10.12, STAH10.12
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445AllantoinasePRO_0000165943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei150 – 1501N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi100226.SCO6247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RKU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0044.
    HOGENOMiHOG000219146.
    KOiK01466.
    OMAiCSPWEGH.
    OrthoDBiEOG6KHFW6.
    PhylomeDBiQ9RKU5.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01645. Hydantoinase.
    InterProiIPR017593. Allantoinase.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RKU5-1 [UniParc]FASTAAdd to Basket

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    MSEAELVLRS TRVITPEGTR AASVAVTGEK ITAVLPYDAP VPAGARLEDV    50
    GDHVVLPGLV DTHVHVNDPG RTEWEGFWTA TRAAAAGGIT TLVDMPLNSI 100
    PPTTTVDNLR TKREVAADKA HIDVGFWGGA LPDNVKDLRP LHEAGVFGFK 150
    AFLSPSGVDE FPHLDQEQLA RSLAEIAAFD GLLIVHAEDP HHLAAAPQQG 200
    GPKYTHFLAS RPRDAEDTAI ATLLAQAKRF NARVHVLHLS SSDALPLIAE 250
    ARADGVRVTV ETCPHYLTLT AEEVPDGASE FKCCPPIREA ANQDLLWQAL 300
    ADGTIDCVVT DHSPSTADLK TDDFATAWGG IAGLQLSLPA MWTAARGRGL 350
    GLEDVVRWMS ERTAALVGLD ARKGAIAPGH DADFAVLAPD ETFTVDPAAL 400
    QHRNRVTAYA GKTLYGVVKS TWLRGERIVA DGAFTDPKGQ LLDRA 445
    Length:445
    Mass (Da):47,492
    Last modified:May 1, 2000 - v1
    Checksum:i75955C5F98632570
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939126 Genomic DNA. Translation: CAB60166.1.
    RefSeqiNP_630347.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB60166; CAB60166; CAB60166.
    GeneIDi1101688.
    KEGGisco:SCO6247.
    PATRICi23742428. VBIStrCoe124346_6361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939126 Genomic DNA. Translation: CAB60166.1 .
    RefSeqi NP_630347.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9RKU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO6247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB60166 ; CAB60166 ; CAB60166 .
    GeneIDi 1101688.
    KEGGi sco:SCO6247.
    PATRICi 23742428. VBIStrCoe124346_6361.

    Phylogenomic databases

    eggNOGi COG0044.
    HOGENOMi HOG000219146.
    KOi K01466.
    OMAi CSPWEGH.
    OrthoDBi EOG6KHFW6.
    PhylomeDBi Q9RKU5.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01645. Hydantoinase.
    InterProi IPR017593. Allantoinase.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiALLB_STRCO
    AccessioniPrimary (citable) accession number: Q9RKU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3