Q9RJZ6 (ALDH_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable aldehyde dehydrogenase
EC=1.2.1.3

Gene names

Ordered Locus Names:	SCO1174
ORF Names:	SCG11A.05

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Probable aldehyde dehydrogenase		PRO_0000056464
Regions
	Nucleotide binding	219 – 225	7	NAD By similarity
Sites
	Active site	263	1	By similarity
	Active site	302	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RJZ6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0110815B2D8F96DD	FASTA	507	55,674
	10 20 30 40 50 60 MTRYAAPGTE GAIVSYQSRY DHFIGGEYVP PARGQYFENP SPVNGLPFTE IARGTADDVE 70 80 90 100 110 120 RALDAAHEAA PGWGRTSVTE RSDILLKIAD RMEANLERLA VAESWENGKP VRETLAADIP 130 140 150 160 170 180 LAIDHFRYFA GAVRAQEGSL GEIDDDTVAY HFHEPLGVVA QIIPWNFPIL MATWKLAPAL 190 200 210 220 230 240 AAGNAVVLKP AEQTPASIHY WLSLVADLLP PGVLNVVNGF GVEAGKPLAS SPRVAKVAFT 250 260 270 280 290 300 GETTTGRLIM QYASENIKPV TLELGGKSPN IFFEDVWARD DDFRDKALEG FTMFALNQGE 310 320 330 340 350 360 VCTCPSRALV QRGVYAEFME AAVARTELIK PGHPLDTDTM IGAQASNDQL EKILSYLDIG 370 380 390 400 410 420 RQEGAKVLTG GERIEHDGEL KGGYYVQPTI FEGHNRMRIF QEEIFGPVVS VTSFDDFDDA 430 440 450 460 470 480 VKTANDTLYG LGAGVWTRDM NTAYRAGRAI QAGRVWTNCY HAYPAHAAFG GYKQSGIGRE 490 500 NHKMMLEHYQ QTKNILCSYS PKKLGFF

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939108 Genomic DNA. Translation: CAB61586.1.
RefSeq	NP_625464.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9RJZ6.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO1174.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB61586; CAB61586; CAB61586.
GeneID	1096597.
KEGG	sco:SCO1174.
PATRIC	23731898. VBIStrCoe124346_1172.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271505.
KO	K00128.
OMA	ASENIKP.
ProtClustDB	CLSK902094.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_STRCO

Accession

Primary (citable) accession number: Q9RJZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program