Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable aldehyde dehydrogenase

Gene

SCO1174

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631By similarity
Active sitei302 – 3021By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi219 – 2257NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Ordered Locus Names:SCO1174
ORF Names:SCG11A.05
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Probable aldehyde dehydrogenasePRO_0000056464Add
BLAST

Proteomic databases

PRIDEiQ9RJZ6.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1174.

Structurei

3D structure databases

ProteinModelPortaliQ9RJZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9RJZ6.
KOiK00138.
OMAiLLGNNKM.
OrthoDBiEOG6BS8QW.
PhylomeDBiQ9RJZ6.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RJZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRYAAPGTE GAIVSYQSRY DHFIGGEYVP PARGQYFENP SPVNGLPFTE
60 70 80 90 100
IARGTADDVE RALDAAHEAA PGWGRTSVTE RSDILLKIAD RMEANLERLA
110 120 130 140 150
VAESWENGKP VRETLAADIP LAIDHFRYFA GAVRAQEGSL GEIDDDTVAY
160 170 180 190 200
HFHEPLGVVA QIIPWNFPIL MATWKLAPAL AAGNAVVLKP AEQTPASIHY
210 220 230 240 250
WLSLVADLLP PGVLNVVNGF GVEAGKPLAS SPRVAKVAFT GETTTGRLIM
260 270 280 290 300
QYASENIKPV TLELGGKSPN IFFEDVWARD DDFRDKALEG FTMFALNQGE
310 320 330 340 350
VCTCPSRALV QRGVYAEFME AAVARTELIK PGHPLDTDTM IGAQASNDQL
360 370 380 390 400
EKILSYLDIG RQEGAKVLTG GERIEHDGEL KGGYYVQPTI FEGHNRMRIF
410 420 430 440 450
QEEIFGPVVS VTSFDDFDDA VKTANDTLYG LGAGVWTRDM NTAYRAGRAI
460 470 480 490 500
QAGRVWTNCY HAYPAHAAFG GYKQSGIGRE NHKMMLEHYQ QTKNILCSYS

PKKLGFF
Length:507
Mass (Da):55,674
Last modified:May 1, 2000 - v1
Checksum:i0110815B2D8F96DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAB61586.1.
RefSeqiNP_625464.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB61586; CAB61586; CAB61586.
GeneIDi1096597.
KEGGisco:SCO1174.
PATRICi23731898. VBIStrCoe124346_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAB61586.1.
RefSeqiNP_625464.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9RJZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1174.

Proteomic databases

PRIDEiQ9RJZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB61586; CAB61586; CAB61586.
GeneIDi1096597.
KEGGisco:SCO1174.
PATRICi23731898. VBIStrCoe124346_1172.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9RJZ6.
KOiK00138.
OMAiLLGNNKM.
OrthoDBiEOG6BS8QW.
PhylomeDBiQ9RJZ6.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiALDH_STRCO
AccessioniPrimary (citable) accession number: Q9RJZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.