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Q9RJS6

- NADK1_STRCO

UniProt

Q9RJS6 - NADK1_STRCO

Protein

NAD kinase 1

Gene

nadK1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Proton acceptorUniRule annotation
    Binding sitei73 – 731NADUniRule annotation
    Binding sitei186 – 1861NADUniRule annotation
    Binding sitei205 – 2051NADUniRule annotation
    Binding sitei240 – 2401NAD; via carbonyl oxygenUniRule annotation
    Binding sitei275 – 2751NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 692NADUniRule annotation
    Nucleotide bindingi175 – 1762NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 1UniRule annotation
    Gene namesi
    Name:nadK1UniRule annotation
    Ordered Locus Names:SCO0410
    ORF Names:SCF51.09c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363NAD kinase 1PRO_0000229699Add
    BLAST

    Proteomic databases

    PRIDEiQ9RJS6.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO0410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RJS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227223.
    KOiK00858.
    OrthoDBiEOG6PZXDR.
    PhylomeDBiQ9RJS6.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9RJS6-1 [UniParc]FASTAAdd to Basket

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    MTIERVGLVV HGGREGAAEA AREVREWCDE NAVACTDIDV WSDTGRHSAR    50
    EEVDAAGDPD LVVTLGGDGT FLRGARLAAE NDALILGVDL GRVGFLTEVP 100
    APAVRSALDA VRDGGLEPES RMLLTLRASR LLEIPAEMEA LLRYGRGPLL 150
    PPPRVRTDCE SGDEWGIALN VTALNDVVLE KLSRDRQISV GVYIAGRLLA 200
    SYSADALLVA TPTGSTAYSF AAGGPVVSPR AEALVFTAVA PHMTFDRSVV 250
    TAPDEPVGLR ILERSGRAAV SIDGQLRGVL DPGDWLGVYA APRRLRAVRL 300
    GPMDFYGRLR ERMRLTDAPA AVADGTPAPL WPVSTPPPGD LAHLALPVPG 350
    AEGASGDLLR EQS 363
    Length:363
    Mass (Da):38,412
    Last modified:April 4, 2006 - v2
    Checksum:i3BE603B1286D310C
    GO

    Sequence cautioni

    The sequence CAB59707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939105 Genomic DNA. Translation: CAB59707.1. Different initiation.
    RefSeqiNP_624731.1. NC_003888.3.
    WP_011027094.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB59707; CAB59707; CAB59707.
    GeneIDi1095833.
    KEGGisco:SCO0410.
    PATRICi23730328. VBIStrCoe124346_0386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939105 Genomic DNA. Translation: CAB59707.1 . Different initiation.
    RefSeqi NP_624731.1. NC_003888.3.
    WP_011027094.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9RJS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO0410.

    Proteomic databases

    PRIDEi Q9RJS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB59707 ; CAB59707 ; CAB59707 .
    GeneIDi 1095833.
    KEGGi sco:SCO0410.
    PATRICi 23730328. VBIStrCoe124346_0386.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227223.
    KOi K00858.
    OrthoDBi EOG6PZXDR.
    PhylomeDBi Q9RJS6.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiNADK1_STRCO
    AccessioniPrimary (citable) accession number: Q9RJS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3