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Protein

NAD kinase 1

Gene

nadK1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei73NADUniRule annotation1
Binding sitei186NADUniRule annotation1
Binding sitei205NADUniRule annotation1
Binding sitei240NAD; via carbonyl oxygenUniRule annotation1
Binding sitei275NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi175 – 176NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 1UniRule annotation
Gene namesi
Name:nadK1UniRule annotation
Ordered Locus Names:SCO0410
ORF Names:SCF51.09c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296991 – 363NAD kinase 1Add BLAST363

Proteomic databases

PRIDEiQ9RJS6

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO0410

Structurei

3D structure databases

ProteinModelPortaliQ9RJS6
SMRiQ9RJS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227223
InParanoidiQ9RJS6
KOiK00858
OrthoDBiPOG091H02D1
PhylomeDBiQ9RJS6

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103301 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 2 hits

Sequencei

Sequence statusi: Complete.

Q9RJS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIERVGLVV HGGREGAAEA AREVREWCDE NAVACTDIDV WSDTGRHSAR
60 70 80 90 100
EEVDAAGDPD LVVTLGGDGT FLRGARLAAE NDALILGVDL GRVGFLTEVP
110 120 130 140 150
APAVRSALDA VRDGGLEPES RMLLTLRASR LLEIPAEMEA LLRYGRGPLL
160 170 180 190 200
PPPRVRTDCE SGDEWGIALN VTALNDVVLE KLSRDRQISV GVYIAGRLLA
210 220 230 240 250
SYSADALLVA TPTGSTAYSF AAGGPVVSPR AEALVFTAVA PHMTFDRSVV
260 270 280 290 300
TAPDEPVGLR ILERSGRAAV SIDGQLRGVL DPGDWLGVYA APRRLRAVRL
310 320 330 340 350
GPMDFYGRLR ERMRLTDAPA AVADGTPAPL WPVSTPPPGD LAHLALPVPG
360
AEGASGDLLR EQS
Length:363
Mass (Da):38,412
Last modified:April 4, 2006 - v2
Checksum:i3BE603B1286D310C
GO

Sequence cautioni

The sequence CAB59707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939105 Genomic DNA Translation: CAB59707.1 Different initiation.
RefSeqiNP_624731.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB59707; CAB59707; CAB59707
GeneIDi1095833
KEGGisco:SCO0410
PATRICifig|100226.15.peg.386

Similar proteinsi

Entry informationi

Entry nameiNADK1_STRCO
AccessioniPrimary (citable) accession number: Q9RJS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome