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Q9RJS6 (NADK1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase 1

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase 1
Gene names
Name:nadK1
Ordered Locus Names:SCO0410
ORF Names:SCF51.09c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Sequence caution

The sequence CAB59707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363NAD kinase 1 HAMAP-Rule MF_00361
PRO_0000229699

Regions

Nucleotide binding68 – 692NAD By similarity
Nucleotide binding175 – 1762NAD By similarity

Sites

Active site681Proton acceptor By similarity
Binding site731NAD By similarity
Binding site1861NAD By similarity
Binding site2051NAD By similarity
Binding site2401NAD; via carbonyl oxygen By similarity
Binding site2751NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RJS6 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 3BE603B1286D310C

FASTA36338,412
        10         20         30         40         50         60 
MTIERVGLVV HGGREGAAEA AREVREWCDE NAVACTDIDV WSDTGRHSAR EEVDAAGDPD 

        70         80         90        100        110        120 
LVVTLGGDGT FLRGARLAAE NDALILGVDL GRVGFLTEVP APAVRSALDA VRDGGLEPES 

       130        140        150        160        170        180 
RMLLTLRASR LLEIPAEMEA LLRYGRGPLL PPPRVRTDCE SGDEWGIALN VTALNDVVLE 

       190        200        210        220        230        240 
KLSRDRQISV GVYIAGRLLA SYSADALLVA TPTGSTAYSF AAGGPVVSPR AEALVFTAVA 

       250        260        270        280        290        300 
PHMTFDRSVV TAPDEPVGLR ILERSGRAAV SIDGQLRGVL DPGDWLGVYA APRRLRAVRL 

       310        320        330        340        350        360 
GPMDFYGRLR ERMRLTDAPA AVADGTPAPL WPVSTPPPGD LAHLALPVPG AEGASGDLLR 


EQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939105 Genomic DNA. Translation: CAB59707.1. Different initiation.
RefSeqNP_624731.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9RJS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO0410.

Proteomic databases

PRIDEQ9RJS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB59707; CAB59707; CAB59707.
GeneID1095833.
KEGGsco:SCO0410.
PATRIC23730328. VBIStrCoe124346_0386.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227223.
KOK00858.
OrthoDBEOG6PZXDR.
PhylomeDBQ9RJS6.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 2 hits.
ProtoNetSearch...

Entry information

Entry nameNADK1_STRCO
AccessionPrimary (citable) accession number: Q9RJS6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families