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Q9RJS6

- NADK1_STRCO

UniProt

Q9RJS6 - NADK1_STRCO

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Protein
NAD kinase 1
Gene
nadK1, SCO0410, SCF51.09c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Proton acceptor By similarity
Binding sitei73 – 731NAD By similarity
Binding sitei186 – 1861NAD By similarity
Binding sitei205 – 2051NAD By similarity
Binding sitei240 – 2401NAD; via carbonyl oxygen By similarity
Binding sitei275 – 2751NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 692NAD By similarity
Nucleotide bindingi175 – 1762NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 1
Gene namesi
Name:nadK1
Ordered Locus Names:SCO0410
ORF Names:SCF51.09c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363NAD kinase 1UniRule annotation
PRO_0000229699Add
BLAST

Proteomic databases

PRIDEiQ9RJS6.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO0410.

Structurei

3D structure databases

ProteinModelPortaliQ9RJS6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
KOiK00858.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ9RJS6.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9RJS6-1 [UniParc]FASTAAdd to Basket

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MTIERVGLVV HGGREGAAEA AREVREWCDE NAVACTDIDV WSDTGRHSAR    50
EEVDAAGDPD LVVTLGGDGT FLRGARLAAE NDALILGVDL GRVGFLTEVP 100
APAVRSALDA VRDGGLEPES RMLLTLRASR LLEIPAEMEA LLRYGRGPLL 150
PPPRVRTDCE SGDEWGIALN VTALNDVVLE KLSRDRQISV GVYIAGRLLA 200
SYSADALLVA TPTGSTAYSF AAGGPVVSPR AEALVFTAVA PHMTFDRSVV 250
TAPDEPVGLR ILERSGRAAV SIDGQLRGVL DPGDWLGVYA APRRLRAVRL 300
GPMDFYGRLR ERMRLTDAPA AVADGTPAPL WPVSTPPPGD LAHLALPVPG 350
AEGASGDLLR EQS 363
Length:363
Mass (Da):38,412
Last modified:April 4, 2006 - v2
Checksum:i3BE603B1286D310C
GO

Sequence cautioni

The sequence CAB59707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939105 Genomic DNA. Translation: CAB59707.1. Different initiation.
RefSeqiNP_624731.1. NC_003888.3.
WP_011027094.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB59707; CAB59707; CAB59707.
GeneIDi1095833.
KEGGisco:SCO0410.
PATRICi23730328. VBIStrCoe124346_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939105 Genomic DNA. Translation: CAB59707.1 . Different initiation.
RefSeqi NP_624731.1. NC_003888.3.
WP_011027094.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9RJS6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO0410.

Proteomic databases

PRIDEi Q9RJS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB59707 ; CAB59707 ; CAB59707 .
GeneIDi 1095833.
KEGGi sco:SCO0410.
PATRICi 23730328. VBIStrCoe124346_0386.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
KOi K00858.
OrthoDBi EOG6PZXDR.
PhylomeDBi Q9RJS6.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiNADK1_STRCO
AccessioniPrimary (citable) accession number: Q9RJS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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