Reviewed, UniProtKB/Swiss-Prot Q9RJS6 (PPNK1_STRCO)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 1
      Short name=Poly(P)/ATP NAD kinase 1
    EC=2.7.1.23

Gene names

Name:	ppnK1
Ordered Locus Names:	SCO0410
ORF Names:	SCF51.09c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Probable inorganic polyphosphate/ATP-NAD kinase 1 HAMAP MF_00361		PRO_0000229699

Sequences

	Sequence		Length	Mass (Da)
	Q9RJS6-1 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 3BE603B1286D310C	FASTA	363	38,412
	10 20 30 40 50 60 MTIERVGLVV HGGREGAAEA AREVREWCDE NAVACTDIDV WSDTGRHSAR EEVDAAGDPD 70 80 90 100 110 120 LVVTLGGDGT FLRGARLAAE NDALILGVDL GRVGFLTEVP APAVRSALDA VRDGGLEPES 130 140 150 160 170 180 RMLLTLRASR LLEIPAEMEA LLRYGRGPLL PPPRVRTDCE SGDEWGIALN VTALNDVVLE 190 200 210 220 230 240 KLSRDRQISV GVYIAGRLLA SYSADALLVA TPTGSTAYSF AAGGPVVSPR AEALVFTAVA 250 260 270 280 290 300 PHMTFDRSVV TAPDEPVGLR ILERSGRAAV SIDGQLRGVL DPGDWLGVYA APRRLRAVRL 310 320 330 340 350 360 GPMDFYGRLR ERMRLTDAPA AVADGTPAPL WPVSTPPPGD LAHLALPVPG AEGASGDLLR EQS

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939105 Genomic DNA. Translation: CAB59707.1. Different initiation.
RefSeq	NP_624731.1.
3D structure databases
SMR	Q9RJS6. Positions 4-316.
ModBase	Search...
Genome annotation databases
GeneID	1095833.
KEGG	sco:SCO0410.
NMPDR	fig|100226.1.peg.384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO0410-MONOMER.
BRENDA	2.7.1.23. 1084.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK1_STRCO

Accession

Primary (citable) accession number: Q9RJS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	February 9, 2010
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)