Q9RJM2 (GLPK2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase 2
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerokinase 2
Short name=GK 2

Gene names

Name:	glpK2
Ordered Locus Names:	SCO0509
ORF Names:	SCF6.05

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Glycerol kinase 2 HAMAP MF_00186		PRO_0000059503
Regions
	Nucleotide binding	416 – 420	5	ATP By similarity
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	16	1	ATP By similarity
	Binding site	82	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity
	Binding site	249	1	Substrate By similarity
	Binding site	271	1	ATP By similarity
	Binding site	315	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RJM2 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 472BB3A469961A63	FASTA	507	55,553
	10 20 30 40 50 60 MADFIGAVDQ GTTSTRFMIF DHGGNEVAKH QLEHEQILPR SGWVEHDPVE IWERTNSVMQ 70 80 90 100 110 120 NALRNGGLSG TDLAAIGITN QRETTVVWDP RTGRPYYNAI VWQDTRTDAI AANLERSGRG 130 140 150 160 170 180 DVIRRKAGLP PATYFSGGKI QWILENVDGV REAAEQGHAV FGNTDSWVLW NLTGGPDGGI 190 200 210 220 230 240 HATDVTNASR TMLMNLETLD WDDELLGFFG IPRGMLPTIN PSSHPEAFGT TRTSRPLRAA 250 260 270 280 290 300 VPITGVLGDQ HAATVGQVCF SPGEAKNTYG TGNFLVLNTG TELVRSQHGL LTTVAYQFGD 310 320 330 340 350 360 NPPVYALEGS IAVTGSAVQW LRDQMKIIKT AAESEELART VEDNGGMYFV PAFSGLFAPY 370 380 390 400 410 420 WRSDARGAIV GLARYNDNAH LARATLEAIC YQSRDVVVAM EQDSSVHLDV LRVDGGVTAN 430 440 450 460 470 480 DLCMQIQADI LGVPVSRPVV AETTALGAAY AAGLATGFWR HTDELRTHWS ESRRWEPQWS 490 500 EERRAQGYAG WKMAVERTLD WVKVPES

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939105 Genomic DNA. Translation: CAB58269.1.
RefSeq	NP_624825.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9RJM2.
SMR	Q9RJM2. Positions 2-502.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1095932.
GenomeReviews	Gene locus SCO0509 in contig AL645882_GR.
KEGG	sco:SCO0509.
NMPDR	fig|100226.1.peg.482.
PATRIC	23730534. VBIStrCoe124346_0489.
Phylogenomic databases
HOGENOM	HBG511469.
OMA	CAVEACH.
PhylomeDB	Q9RJM2.
ProtClustDB	PRK00047.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK2_STRCO

Accession

Primary (citable) accession number: Q9RJM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program