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Protein
Submitted name:

Beta-mannosidase

Gene

manB

Organism
Thermotoga maritima
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi516 – 5161Calcium; via carbonyl oxygenCombined sources
Metal bindingi548 – 5481Calcium; via carbonyl oxygenCombined sources
Metal bindingi550 – 5501Calcium; via carbonyl oxygenCombined sources
Binding sitei599 – 5991Beta-D-mannoseCombined sources
Binding sitei614 – 6141Beta-D-mannoseCombined sources
Metal bindingi669 – 6691CalciumCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Protein family/group databases

CAZyiCBM27. Carbohydrate-Binding Module Family 27.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-mannosidaseImported
Gene namesi
Name:manBImported
OrganismiThermotoga maritimaImported
Taxonomic identifieri2336 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1227.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OF3X-ray2.00A/B505-680[»]
1OF4X-ray1.60A505-680[»]
1OH4X-ray1.35A505-680[»]
ProteinModelPortaliQ9RIK9.
SMRiQ9RIK9. Positions 507-680.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RIK9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 362318CellulaseInterPro annotationAdd
BLAST
Domaini508 – 676169CBM27InterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni563 – 5686Beta-D-mannose bindingCombined sources
Regioni608 – 6103Beta-D-mannose bindingCombined sources

Phylogenomic databases

eggNOGiENOG41081JG. Bacteria.
COG3934. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR015295. Carb-bd_module_27.
IPR008979. Galactose-bd-like.
IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF09212. CBM27. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RIK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIGGDDSWS PSVSAEFLLL IVELSFVLFA SDEFVKVENG KFALNGKEFR
60 70 80 90 100
FIGSNNYYMH YKSNGMIDSV LESARDMGIK VLRIWGFLDG ESYCRDKNTY
110 120 130 140 150
MHPEPGVFGV PEGISNAQSG FERLDYTVAK AKELGIKLVI VLVNNWDDFG
160 170 180 190 200
GMNQYVRWFG GTHHDDFYRD EKIKEEYKKY VSFLVNHVNT YTGVPYREEP
210 220 230 240 250
TIMAWELANE PRCETDKSGN TLVEWVKEMS SYIKSLDPNH LVAVGDEGFF
260 270 280 290 300
SNYEGFKPYG GEAEWAYNGW SGVDWKKLLS IETVDFGTFH LYPSHWGVSP
310 320 330 340 350
ENYAQWGAKW IEDHIKIAKE IGKPVVLEEY GIPKSAPVNR TAIYRLWNDL
360 370 380 390 400
VYDLGGDGAM FWMLAGIGEG SDRDERGYYP DYDGFRIVND DSPEAELIRE
410 420 430 440 450
YAKLFNTGED IREDTCSFIL PKDGMEIKKT VEVRAGVFDY SNTFEKLSVK
460 470 480 490 500
VEDLVFENEI EHLGYGIYGF DLDTTRIPDG EHEMFLEGHF QGKTVKDSIK
510 520 530 540 550
AKVVNEARYV LAEEVDFSSP EEVKNWWNSG TWQAEFGSPD IEWNGEVGNG
560 570 580 590 600
ALQLNVKLPG KSDWEEVRVA RKFERLSECE ILEYDIYIPN VEGLKGRLRP
610 620 630 640 650
YAVLNPGWVK IGLDMNNANV ESAEIITFGG KEYRRFHVRI EFDRTAGVKE
660 670 680
LHIGVVGDHL RYDGPIFIDN VRLYKRTGGM
Length:680
Mass (Da):77,687
Last modified:May 1, 2000 - v1
Checksum:i5BA3F6982194D1AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17980 Genomic DNA. Translation: CAB56854.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17980 Genomic DNA. Translation: CAB56854.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OF3X-ray2.00A/B505-680[»]
1OF4X-ray1.60A505-680[»]
1OH4X-ray1.35A505-680[»]
ProteinModelPortaliQ9RIK9.
SMRiQ9RIK9. Positions 507-680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1227.

Protein family/group databases

CAZyiCBM27. Carbohydrate-Binding Module Family 27.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41081JG. Bacteria.
COG3934. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ9RIK9.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR015295. Carb-bd_module_27.
IPR008979. Galactose-bd-like.
IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF09212. CBM27. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Amino Acid Sequence of beta-mannosidase genes from the hyperthermophilic bacteria Thermotoga maritima and Thermotoga neapolitana."
    Parker K.N., Lam D., Duffaud G., Snead M.A., Mathur E.J., Kelly R.M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MSB8Imported.
  2. "Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27."
    Boraston A.B., Revett T.J., Boraston C.M., Nurizzo D., Davies G.J.
    Structure 11:665-675(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 505-680 IN COMPLEX WITH BETA-D-MANNOSE AND CALCIUM.

Entry informationi

Entry nameiQ9RIK9_THEMT
AccessioniPrimary (citable) accession number: Q9RIK9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.