Q9RHV8 (DSBA_BURCE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:

dsbA

Organism

Burkholderia cepacia (Pseudomonas cepacia)

Taxonomic identifier

292 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Involved in the production of protease and alkaline phosphatase, motility, metal resistance, and multi-drug resistance.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 212	191	Thiol:disulfide interchange protein DsbA		PRO_0000034251
Amino acid modifications
	Disulfide bond	58 ↔ 61		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9RHV8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4984916096593143	FASTA	212	23,233
	10 20 30 40 50 60 MKKLLSTLLL SLGLAAGLAQ ASPAAPASGK DFEVMKSPQP VSAPAGKVEV IEFFWYGCPH 70 80 90 100 110 120 CYEFEPTIEA WVKKQGNNID FKRVPVAFRD DFLPHSKLFY AVSALGISEK VTPAIFNAIH 130 140 150 160 170 180 KQKNYLLTPQ AQADFLATQG VDKKKFMDAY NSFSVQGEVN QSAKLLKDYA IDGVPTVVVQ 190 200 210 GKYKTGPAYT NSIPGTAQVL DFLVKQVQDK KL

References

[1]	"The DsbA-DsbB disulfide bond formation system of Burkholderia cepacia is involved in the production of protease and alkaline phosphatase, motility, metal resistance, and multi-drug resistance." Hayashi S., Abe M., Kimoto M., Furukawa S., Nakazawa T. Microbiol. Immunol. 44:41-50(2000) [PubMed: 10711598] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KF1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012578 Genomic DNA. Translation: BAA89224.1.
3D structure databases
ProteinModelPortal	Q9RHV8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_BURCE

Accession

Primary (citable) accession number: Q9RHV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program