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Q9RHN2 (ACDH2_COMTE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Name:aphF
OrganismComamonas testosteroni (Pseudomonas testosteroni)
Taxonomic identifier285 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387651

Regions

Nucleotide binding162 – 1709NAD By similarity

Sites

Active site1311Acyl-thioester intermediate By similarity
Binding site2731NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RHN2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 58120F1B782621E3

FASTA30732,366
        10         20         30         40         50         60 
MSQKIKCALI GPGNIGTDLL AKLQRSPVLE PVWMVGIDPD SDGLKRAREM GIKTTAEGVD 

        70         80         90        100        110        120 
GLLPHMHVDG VQIVFDATSA YVHAENSRKV NERGALMIDL TPAAIGPFCV PPVNLIQHLG 

       130        140        150        160        170        180 
SGAMNVNMVT CGGQATIPMV AAVSRVQAVA YGEIVATVSS KSVGPGTRKN IDEFTRTTAG 

       190        200        210        220        230        240 
AVEKVGGAKK GKAIIVINPA EPPLMMRDTV HCLTEDEPDQ AAITASIHQM LAEVQKYVPG 

       250        260        270        280        290        300 
YRLVNGPVFD GKRVSVFLEV EGLGDYLPKY AGNLDIMTAA AARTAEMFAE QMLAGKLTLA 


PVAPIAA 

« Hide

References

[1]"Arrangement and regulation of the genes for meta-pathway enzymes required for degradation of phenol in Comamonas testosteroni TA441."
Arai H., Ohishi T., Chang M.Y., Kudo T.
Microbiology 146:1707-1715(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: TA441.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029044 Genomic DNA. Translation: BAA88503.1.

3D structure databases

ProteinModelPortalQ9RHN2.
SMRQ9RHN2. Positions 1-294.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_COMTE
AccessionPrimary (citable) accession number: Q9RHN2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families