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Protein

Urease subunit gamma

Gene

ureA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gammaUniRule annotation
Gene namesi
Name:ureAUniRule annotation
Ordered Locus Names:Cgl0084, cg0113
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Urease subunit gammaPRO_0000098010Add
BLAST

Expressioni

Inductioni

By urea and nitrogen starvation.2 Publications

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg0113.

Structurei

3D structure databases

ProteinModelPortaliQ9RHM6.
SMRiQ9RHM6. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YZ9. Bacteria.
COG0831. LUCA.
HOGENOMiHOG000075053.
KOiK01430.
OMAiELMSYGT.
OrthoDBiEOG69PQ9G.

Family and domain databases

Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RHM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHITPREQEK LMIVVAADLA RRRKDRGLKL NHPEAVALIT YELIEGARDG
60 70 80 90 100
RTVADLMSWG STILTRDDVL EGIPEMIPDI QVEATFDDGT KLVTVHNPIR
Length:100
Mass (Da):11,245
Last modified:May 1, 2000 - v1
Checksum:iA48F4DC0EABD9567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251883 Genomic DNA. Translation: CAB81935.1.
AB029154 Genomic DNA. Translation: BAA88552.1.
BA000036 Genomic DNA. Translation: BAB97477.1.
BX927148 Genomic DNA. Translation: CAF18652.1.
RefSeqiNP_599336.1. NC_003450.3.
WP_003857708.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB97477; BAB97477; BAB97477.
CAF18652; CAF18652; cg0113.
GeneIDi1021068.
KEGGicgb:cg0113.
cgl:NCgl0083.
PATRICi21492212. VBICorGlu203724_0085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251883 Genomic DNA. Translation: CAB81935.1.
AB029154 Genomic DNA. Translation: BAA88552.1.
BA000036 Genomic DNA. Translation: BAB97477.1.
BX927148 Genomic DNA. Translation: CAF18652.1.
RefSeqiNP_599336.1. NC_003450.3.
WP_003857708.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ9RHM6.
SMRiQ9RHM6. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg0113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB97477; BAB97477; BAB97477.
CAF18652; CAF18652; cg0113.
GeneIDi1021068.
KEGGicgb:cg0113.
cgl:NCgl0083.
PATRICi21492212. VBICorGlu203724_0085.

Phylogenomic databases

eggNOGiENOG4108YZ9. Bacteria.
COG0831. LUCA.
HOGENOMiHOG000075053.
KOiK01430.
OMAiELMSYGT.
OrthoDBiEOG69PQ9G.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the urease operon of Corynebacterium glutamicum."
    Puskas L.G., Inui M., Yukawa H.
    DNA Seq. 11:383-394(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: ATCC 13869 / DSMZ 1412 / NCIMB 9567.
  2. "Urease of Corynebacterium glutamicum: organization of corresponding genes and investigation of activity."
    Nolden L., Beckers G., Moeckel B., Pfefferle W., Nampoothiri K.M., Kraemer R., Burkovski A.
    FEMS Microbiol. Lett. 189:305-310(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], OPERON STRUCTURE.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  5. "Molecular identification of the urea uptake system and transcriptional analysis of urea transporter- and urease-encoding genes in Corynebacterium glutamicum."
    Beckers G., Bendt A.K., Kraemer R., Burkovski A.
    J. Bacteriol. 186:7645-7652(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiURE3_CORGL
AccessioniPrimary (citable) accession number: Q9RHM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.