Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9RH05

- HISX_ZYMMO

UniProt

Q9RH05 - HISX_ZYMMO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADBy similarity
Binding sitei191 – 1911NADBy similarity
Binding sitei214 – 2141NADBy similarity
Binding sitei237 – 2371SubstrateBy similarity
Metal bindingi259 – 2591ZincBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Metal bindingi262 – 2621ZincBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Active sitei327 – 3271Proton acceptorBy similarity
Active sitei328 – 3281Proton acceptorBy similarity
Binding sitei328 – 3281SubstrateBy similarity
Metal bindingi361 – 3611ZincBy similarity
Binding sitei361 – 3611SubstrateBy similarity
Binding sitei415 – 4151SubstrateBy similarity
Metal bindingi420 – 4201ZincBy similarity
Binding sitei420 – 4201SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Synonyms:hdh
Ordered Locus Names:ZMO1551
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Histidinol dehydrogenasePRO_0000135889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO1551.

Structurei

3D structure databases

ProteinModelPortaliQ9RH05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RH05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLKLDSRKA DFQADFTRLV DERRESEGDV SRDVSAIIAD VKKRGDVAIA
60 70 80 90 100
ELTQKFDRHD LNKGGWQLTQ EEIKKACDSL PSELMDALKL AATRIRYCHE
110 120 130 140 150
NQLPESSEMT DAAGVRMGVR WQAVEAAGLY VPGGRAAYCS SVLMNAVPAK
160 170 180 190 200
VAGVKRLVMV TPTPDGFVNP AVIAAAVISE VDEIWKIGGA QAVAALALGT
210 220 230 240 250
EKIKPVDVVV GPGNAWVAEA KRQLYGQVGI DMVAGPSEIV VVADKDNDPE
260 270 280 290 300
WLAADLLSQA EHDPTSQSIL ISDSEDLIEK TIEAVGRRLE KLETQKVARE
310 320 330 340 350
SWDKHGATIL VQSLDEAPAL VDRLAPEHLE LAVADPDALF ANVHHSGSVF
360 370 380 390 400
LGRYTPEAIG DYVGGPNHVL PTGRRARFSS GLSVIDFMKR TTYLNCSQEA
410 420 430
LSKIGPAAVT LAKAEGLPAH AESVISRLNK
Length:430
Mass (Da):46,339
Last modified:March 23, 2010 - v3
Checksum:i213A0D3F7609A6C4
GO

Sequence cautioni

The sequence AAF18281.1 differs from that shown. Reason: Frameshift at position 10. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti406 – 43025PAAVT…SRLNK → LRL in AAF18281. 1 PublicationCuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088897 Genomic DNA. Translation: AAF18281.1. Frameshift.
AE008692 Genomic DNA. Translation: AAV90175.2.
RefSeqiYP_163286.2. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV90175; AAV90175; ZMO1551.
GeneIDi3188723.
KEGGizmo:ZMO1551.
PATRICi32568356. VBIZymMob102260_1461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088897 Genomic DNA. Translation: AAF18281.1 . Frameshift.
AE008692 Genomic DNA. Translation: AAV90175.2 .
RefSeqi YP_163286.2. NC_006526.2.

3D structure databases

ProteinModelPortali Q9RH05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV90175 ; AAV90175 ; ZMO1551 .
GeneIDi 3188723.
KEGGi zmo:ZMO1551.
PATRICi 32568356. VBIZymMob102260_1461.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kang H.L., Kang H.S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  3. Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiHISX_ZYMMO
AccessioniPrimary (citable) accession number: Q9RH05
Secondary accession number(s): Q5NM85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3