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Q9RH05

- HISX_ZYMMO

UniProt

Q9RH05 - HISX_ZYMMO

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Protein
Histidinol dehydrogenase
Gene
hisD, hdh, ZMO1551
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Active sitei328 – 3281Proton acceptor By similarity
Binding sitei328 – 3281Substrate By similarity
Metal bindingi361 – 3611Zinc By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei415 – 4151Substrate By similarity
Metal bindingi420 – 4201Zinc By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Synonyms:hdh
Ordered Locus Names:ZMO1551
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Histidinol dehydrogenaseUniRule annotation
PRO_0000135889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO1551.

Structurei

3D structure databases

ProteinModelPortaliQ9RH05.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RH05-1 [UniParc]FASTAAdd to Basket

« Hide

MLLKLDSRKA DFQADFTRLV DERRESEGDV SRDVSAIIAD VKKRGDVAIA    50
ELTQKFDRHD LNKGGWQLTQ EEIKKACDSL PSELMDALKL AATRIRYCHE 100
NQLPESSEMT DAAGVRMGVR WQAVEAAGLY VPGGRAAYCS SVLMNAVPAK 150
VAGVKRLVMV TPTPDGFVNP AVIAAAVISE VDEIWKIGGA QAVAALALGT 200
EKIKPVDVVV GPGNAWVAEA KRQLYGQVGI DMVAGPSEIV VVADKDNDPE 250
WLAADLLSQA EHDPTSQSIL ISDSEDLIEK TIEAVGRRLE KLETQKVARE 300
SWDKHGATIL VQSLDEAPAL VDRLAPEHLE LAVADPDALF ANVHHSGSVF 350
LGRYTPEAIG DYVGGPNHVL PTGRRARFSS GLSVIDFMKR TTYLNCSQEA 400
LSKIGPAAVT LAKAEGLPAH AESVISRLNK 430
Length:430
Mass (Da):46,339
Last modified:March 23, 2010 - v3
Checksum:i213A0D3F7609A6C4
GO

Sequence cautioni

The sequence AAF18281.1 differs from that shown. Reason: Frameshift at position 10.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti406 – 43025PAAVT…SRLNK → LRL in AAF18281. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF088897 Genomic DNA. Translation: AAF18281.1. Frameshift.
AE008692 Genomic DNA. Translation: AAV90175.2.
RefSeqiYP_163286.2. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV90175; AAV90175; ZMO1551.
GeneIDi3188723.
KEGGizmo:ZMO1551.
PATRICi32568356. VBIZymMob102260_1461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF088897 Genomic DNA. Translation: AAF18281.1 . Frameshift.
AE008692 Genomic DNA. Translation: AAV90175.2 .
RefSeqi YP_163286.2. NC_006526.2.

3D structure databases

ProteinModelPortali Q9RH05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV90175 ; AAV90175 ; ZMO1551 .
GeneIDi 3188723.
KEGGi zmo:ZMO1551.
PATRICi 32568356. VBIZymMob102260_1461.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kang H.L., Kang H.S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  3. Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiHISX_ZYMMO
AccessioniPrimary (citable) accession number: Q9RH05
Secondary accession number(s): Q5NM85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 23, 2010
Last modified: May 14, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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