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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130NADBy similarity1
Binding sitei191NADBy similarity1
Binding sitei214NADBy similarity1
Binding sitei237SubstrateBy similarity1
Metal bindingi259ZincBy similarity1
Binding sitei259SubstrateBy similarity1
Metal bindingi262ZincBy similarity1
Binding sitei262SubstrateBy similarity1
Active sitei327Proton acceptorBy similarity1
Active sitei328Proton acceptorBy similarity1
Binding sitei328SubstrateBy similarity1
Metal bindingi361ZincBy similarity1
Binding sitei361SubstrateBy similarity1
Binding sitei415SubstrateBy similarity1
Metal bindingi420ZincBy similarity1
Binding sitei420SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Synonyms:hdh
Ordered Locus Names:ZMO1551
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358891 – 430Histidinol dehydrogenaseAdd BLAST430

Structurei

3D structure databases

ProteinModelPortaliQ9RH05.
SMRiQ9RH05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000243914.
KOiK00013.
OMAiQAEHDPM.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
PfamiView protein in Pfam
PF00815. Histidinol_dh. 1 hit.
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiView protein in PROSITE
PS00611. HISOL_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RH05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKLDSRKA DFQADFTRLV DERRESEGDV SRDVSAIIAD VKKRGDVAIA
60 70 80 90 100
ELTQKFDRHD LNKGGWQLTQ EEIKKACDSL PSELMDALKL AATRIRYCHE
110 120 130 140 150
NQLPESSEMT DAAGVRMGVR WQAVEAAGLY VPGGRAAYCS SVLMNAVPAK
160 170 180 190 200
VAGVKRLVMV TPTPDGFVNP AVIAAAVISE VDEIWKIGGA QAVAALALGT
210 220 230 240 250
EKIKPVDVVV GPGNAWVAEA KRQLYGQVGI DMVAGPSEIV VVADKDNDPE
260 270 280 290 300
WLAADLLSQA EHDPTSQSIL ISDSEDLIEK TIEAVGRRLE KLETQKVARE
310 320 330 340 350
SWDKHGATIL VQSLDEAPAL VDRLAPEHLE LAVADPDALF ANVHHSGSVF
360 370 380 390 400
LGRYTPEAIG DYVGGPNHVL PTGRRARFSS GLSVIDFMKR TTYLNCSQEA
410 420 430
LSKIGPAAVT LAKAEGLPAH AESVISRLNK
Length:430
Mass (Da):46,339
Last modified:March 23, 2010 - v3
Checksum:i213A0D3F7609A6C4
GO

Sequence cautioni

The sequence AAF18281 differs from that shown. Reason: Frameshift at position 10.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406 – 430PAAVT…SRLNK → LRL in AAF18281 (Ref. 1) CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088897 Genomic DNA. Translation: AAF18281.1. Frameshift.
AE008692 Genomic DNA. Translation: AAV90175.2.
RefSeqiWP_011241316.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV90175; AAV90175; ZMO1551.
GeneIDi33073745.
KEGGizmo:ZMO1551.

Similar proteinsi

Entry informationi

Entry nameiHISX_ZYMMO
AccessioniPrimary (citable) accession number: Q9RH05
Secondary accession number(s): Q5NM85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 23, 2010
Last modified: September 27, 2017
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families