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Q9RH05

- HISX_ZYMMO

UniProt

Q9RH05 - HISX_ZYMMO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADBy similarity
    Binding sitei191 – 1911NADBy similarity
    Binding sitei214 – 2141NADBy similarity
    Binding sitei237 – 2371SubstrateBy similarity
    Metal bindingi259 – 2591ZincBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Metal bindingi262 – 2621ZincBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Active sitei327 – 3271Proton acceptorBy similarity
    Active sitei328 – 3281Proton acceptorBy similarity
    Binding sitei328 – 3281SubstrateBy similarity
    Metal bindingi361 – 3611ZincBy similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei415 – 4151SubstrateBy similarity
    Metal bindingi420 – 4201ZincBy similarity
    Binding sitei420 – 4201SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Synonyms:hdh
    Ordered Locus Names:ZMO1551
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Histidinol dehydrogenasePRO_0000135889Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264203.ZMO1551.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RH05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RH05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLKLDSRKA DFQADFTRLV DERRESEGDV SRDVSAIIAD VKKRGDVAIA    50
    ELTQKFDRHD LNKGGWQLTQ EEIKKACDSL PSELMDALKL AATRIRYCHE 100
    NQLPESSEMT DAAGVRMGVR WQAVEAAGLY VPGGRAAYCS SVLMNAVPAK 150
    VAGVKRLVMV TPTPDGFVNP AVIAAAVISE VDEIWKIGGA QAVAALALGT 200
    EKIKPVDVVV GPGNAWVAEA KRQLYGQVGI DMVAGPSEIV VVADKDNDPE 250
    WLAADLLSQA EHDPTSQSIL ISDSEDLIEK TIEAVGRRLE KLETQKVARE 300
    SWDKHGATIL VQSLDEAPAL VDRLAPEHLE LAVADPDALF ANVHHSGSVF 350
    LGRYTPEAIG DYVGGPNHVL PTGRRARFSS GLSVIDFMKR TTYLNCSQEA 400
    LSKIGPAAVT LAKAEGLPAH AESVISRLNK 430
    Length:430
    Mass (Da):46,339
    Last modified:March 23, 2010 - v3
    Checksum:i213A0D3F7609A6C4
    GO

    Sequence cautioni

    The sequence AAF18281.1 differs from that shown. Reason: Frameshift at position 10.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti406 – 43025PAAVT…SRLNK → LRL in AAF18281. 1 PublicationCuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF088897 Genomic DNA. Translation: AAF18281.1. Frameshift.
    AE008692 Genomic DNA. Translation: AAV90175.2.
    RefSeqiYP_163286.2. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV90175; AAV90175; ZMO1551.
    GeneIDi3188723.
    KEGGizmo:ZMO1551.
    PATRICi32568356. VBIZymMob102260_1461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF088897 Genomic DNA. Translation: AAF18281.1 . Frameshift.
    AE008692 Genomic DNA. Translation: AAV90175.2 .
    RefSeqi YP_163286.2. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q9RH05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO1551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV90175 ; AAV90175 ; ZMO1551 .
    GeneIDi 3188723.
    KEGGi zmo:ZMO1551.
    PATRICi 32568356. VBIZymMob102260_1461.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kang H.L., Kang H.S.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    3. Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiHISX_ZYMMO
    AccessioniPrimary (citable) accession number: Q9RH05
    Secondary accession number(s): Q5NM85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3