Reviewed, UniProtKB/Swiss-Prot Q9RGX0 (SPX_LISMO)

Names and origin

Protein names

Recommended name:
    Regulatory protein spx

Gene names

Name:	spxA
Ordered Locus Names:	lmo2191

Organism

Listeria monocytogenes [Complete proteome] [HAMAP]

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the arsC family. Spx subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription regulator activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Regulatory protein spx HAMAP MF_01132		PRO_0000162559
Amino acid modifications
	Disulfide bond	10 ↔ 13		Redox-active Potential
Experimental info
	Sequence conflict	16	1	A → S in AAF21893. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9RGX0-1 [UniParc]. Last modified February 16, 2004. Version 2. Checksum: 67181E1BA6CD9444	FASTA	131	15,582
	10 20 30 40 50 60 MVTLYTSPSC TSCRKARAWL EEHDIPYKER NIFSEPLSLD EIKEILRMTE DGTDEIISTR 70 80 90 100 110 120 SKTFQKLNVD LDSLPLQQLF ELIQKNPGLL RRPIIIDEKR LQVGYNEDEI RRFLPRRVRT 130 YQLREAQKMV N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification in Listeria monocytogenes of MecA, a homologue of the Bacillus subtilis competence regulatory protein." Borezee E., Msadek T., Durant L., Berche P. J. Bacteriol. 182:5931-5934(2000) [PubMed: 11004200] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LO28 / Serovar 1/2c.
[2]	"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF103794 Genomic DNA. Translation: AAF21893.1. AL591982 Genomic DNA. Translation: CAD00269.1.
PIR	AG1348.
RefSeq	NP_465715.1. YP_002758906.1.
3D structure databases
SMR	Q9RGX0. Positions 1-118.
ModBase	Search...
Genome annotation databases
GeneID	7702546. 988006.
GenomeReviews	Gene locus lmo2191 in contig AL591824_GR.
KEGG	lmo:lmo2191.
Organism-specific databases
ListiList	LMO02191.
CMR	Search...
Phylogenomic databases
HOGENOM	Q9RGX0.
OMA	Q9RGX0. RRMQVGY.
Enzyme and pathway databases
BioCyc	LMON169963:LMO2191-MON.
Family and domain databases
HAMAP	MF_01132. [Tree]
InterPro	IPR006660. Arsenate_reductase-like. IPR006504. CHP1617_ArsC_rel. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01617. arsC_related. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPX_LISMO

Accession

Primary (citable) accession number: Q9RGX0
Secondary accession number(s): Q929I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	February 16, 2004
Last modified:	June 16, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)