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Q9RGS6

- THIM_STACT

UniProt

Q9RGS6 - THIM_STACT

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Substrate; via amide nitrogenUniRule annotation
Binding sitei116 – 1161ATPUniRule annotation
Binding sitei161 – 1611ATPUniRule annotation
Binding sitei188 – 1881Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:GJ9G-1645-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:Sca_1594
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000444: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Hydroxyethylthiazole kinasePRO_0000156960Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1594.

Structurei

3D structure databases

ProteinModelPortaliQ9RGS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiNACTQLA.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RGS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKILDQIRT EHPLVICYTN DVVKNFTANG LLSLGASPTM SEAPQEAEDF
60 70 80 90 100
YPVAGSVLIN IGTLTKHHEH AMLENAKIAN ETETPLVFDP VAVGASKYRK
110 120 130 140 150
DFCKYFLKKI KPTVIKGNAS EILALIDDTA TMKGTDSADN LDVVDIAEKA
160 170 180 190 200
YKEYQTAIIL TGETDVIVQD NKVVKLSNGS HFLAKITGAG CLLGAVVGAF
210 220 230 240 250
LFRNTHPSIE TLIEAVSVYN IAAERAEQLS DSKGPGTFLT QFIDALYRID
260
SDAVAENCNL EEVK
Length:264
Mass (Da):28,684
Last modified:May 1, 2000 - v1
Checksum:iFAB855DECF208828
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109218 Genomic DNA. Translation: AAF25543.1.
AM295250 Genomic DNA. Translation: CAL28499.1.
RefSeqiWP_015900839.1. NC_012121.1.
YP_002634684.1. NC_012121.1.

Genome annotation databases

GeneIDi7552178.
KEGGisca:Sca_1594.
PATRICi19604037. VBIStaCar105558_1591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109218 Genomic DNA. Translation: AAF25543.1 .
AM295250 Genomic DNA. Translation: CAL28499.1 .
RefSeqi WP_015900839.1. NC_012121.1.
YP_002634684.1. NC_012121.1.

3D structure databases

ProteinModelPortali Q9RGS6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 396513.Sca_1594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7552178.
KEGGi sca:Sca_1594.
PATRICi 19604037. VBIStaCar105558_1591.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi NACTQLA.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SCAR396513:GJ9G-1645-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an operon involved in thiamin biosynthesis in Staphylococcus carnosus TM300."
    Krismer B., Goetz F.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
    Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
    Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM300.

Entry informationi

Entry nameiTHIM_STACT
AccessioniPrimary (citable) accession number: Q9RGS6
Secondary accession number(s): B9DMF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3