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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hydroxyethylthiazole kinase (thiM)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40Substrate; via amide nitrogenUniRule annotation1
Binding sitei116ATPUniRule annotation1
Binding sitei161ATPUniRule annotation1
Binding sitei188Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processThiamine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-1631-MONOMER
UniPathwayiUPA00060; UER00139

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:Sca_1594
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569601 – 264Hydroxyethylthiazole kinaseAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1594

Structurei

3D structure databases

ProteinModelPortaliQ9RGS6
SMRiQ9RGS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4U Bacteria
COG2145 LUCA
HOGENOMiHOG000114352
KOiK00878
OMAiATGQKDF

Family and domain databases

CDDicd01170 THZ_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_00228 Thz_kinase, 1 hit
InterProiView protein in InterPro
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
PANTHERiPTHR44423 PTHR44423, 1 hit
PfamiView protein in Pfam
PF02110 HK, 1 hit
PIRSFiPIRSF000513 Thz_kinase, 1 hit
PRINTSiPR01099 HYETHTZKNASE
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00694 thiM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RGS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKILDQIRT EHPLVICYTN DVVKNFTANG LLSLGASPTM SEAPQEAEDF
60 70 80 90 100
YPVAGSVLIN IGTLTKHHEH AMLENAKIAN ETETPLVFDP VAVGASKYRK
110 120 130 140 150
DFCKYFLKKI KPTVIKGNAS EILALIDDTA TMKGTDSADN LDVVDIAEKA
160 170 180 190 200
YKEYQTAIIL TGETDVIVQD NKVVKLSNGS HFLAKITGAG CLLGAVVGAF
210 220 230 240 250
LFRNTHPSIE TLIEAVSVYN IAAERAEQLS DSKGPGTFLT QFIDALYRID
260
SDAVAENCNL EEVK
Length:264
Mass (Da):28,684
Last modified:May 1, 2000 - v1
Checksum:iFAB855DECF208828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109218 Genomic DNA Translation: AAF25543.1
AM295250 Genomic DNA Translation: CAL28499.1
RefSeqiWP_015900839.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_1594

Similar proteinsi

Entry informationi

Entry nameiTHIM_STACT
AccessioniPrimary (citable) accession number: Q9RGS6
Secondary accession number(s): B9DMF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health