SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9RGS6

- THIM_STACT

UniProt

Q9RGS6 - THIM_STACT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Hydroxyethylthiazole kinase
Gene
thiM, Sca_1594
Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Substrate; via amide nitrogen By similarity
Binding sitei116 – 1161ATP By similarity
Binding sitei161 – 1611ATP By similarity
Binding sitei188 – 1881Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:GJ9G-1645-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:Sca_1594
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000444: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000156960Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1594.

Structurei

3D structure databases

ProteinModelPortaliQ9RGS6.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiNACTQLA.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RGS6-1 [UniParc]FASTAAdd to Basket

« Hide

MNKILDQIRT EHPLVICYTN DVVKNFTANG LLSLGASPTM SEAPQEAEDF    50
YPVAGSVLIN IGTLTKHHEH AMLENAKIAN ETETPLVFDP VAVGASKYRK 100
DFCKYFLKKI KPTVIKGNAS EILALIDDTA TMKGTDSADN LDVVDIAEKA 150
YKEYQTAIIL TGETDVIVQD NKVVKLSNGS HFLAKITGAG CLLGAVVGAF 200
LFRNTHPSIE TLIEAVSVYN IAAERAEQLS DSKGPGTFLT QFIDALYRID 250
SDAVAENCNL EEVK 264
Length:264
Mass (Da):28,684
Last modified:May 1, 2000 - v1
Checksum:iFAB855DECF208828
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109218 Genomic DNA. Translation: AAF25543.1.
AM295250 Genomic DNA. Translation: CAL28499.1.
RefSeqiWP_015900839.1. NC_012121.1.
YP_002634684.1. NC_012121.1.

Genome annotation databases

GeneIDi7552178.
KEGGisca:Sca_1594.
PATRICi19604037. VBIStaCar105558_1591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109218 Genomic DNA. Translation: AAF25543.1 .
AM295250 Genomic DNA. Translation: CAL28499.1 .
RefSeqi WP_015900839.1. NC_012121.1.
YP_002634684.1. NC_012121.1.

3D structure databases

ProteinModelPortali Q9RGS6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 396513.Sca_1594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7552178.
KEGGi sca:Sca_1594.
PATRICi 19604037. VBIStaCar105558_1591.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi NACTQLA.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SCAR396513:GJ9G-1645-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an operon involved in thiamin biosynthesis in Staphylococcus carnosus TM300."
    Krismer B., Goetz F.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
    Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
    Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM300.

Entry informationi

Entry nameiTHIM_STACT
AccessioniPrimary (citable) accession number: Q9RGS6
Secondary accession number(s): B9DMF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi