Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Legionella pneumophila
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei350 – 3501Proton donorBy similarity
Active sitei381 – 3811By similarity
Active sitei485 – 4851By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Synonyms:gpi
OrganismiLegionella pneumophila
Taxonomic identifieri446 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Glucose-6-phosphate isomerasePRO_0000180661Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297246.lpp0825.

Structurei

3D structure databases

ProteinModelPortaliQ9RDY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RDY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRNSMKSHT ELLSWNLLQK EADRVRLNSD SLTCVVPDSN NYESSKQINC
60 70 80 90 100
IEYDYSRQRV NRTIIDLLID LANEVKLQEK IDNLINGKKI NISENRPALH
110 120 130 140 150
TALRDLGNKS IMIDGLDIMS AVINTREKIK VISNQIREKK WLGHSGLPIT
160 170 180 190 200
DIVNIGIGGS DLGPRVCINA LSNYISKEFN YHFISDVDPA SFNDVIAKIN
210 220 230 240 250
PQTTLFIVSS KSFTTKETLL NARKAFALYE DTASIDQHFI AVTAHPERAY
260 270 280 290 300
QMGIKTVLPI WDWVGGRFSF CSAVNLITAI AIGYEQFVEL LAGAHDIDTH
310 320 330 340 350
VQFTDFKNNI PVLMALIGIW NNNFLNIHYD LIGYNFKEYF VPYVQQLDME
360 370 380 390 400
SNGKSIDVNG RMVDYATGPI VWGGLGNQAQ HSYFQLLCQG THRCVGDFIT
410 420 430 440 450
LKTNDEHEIN SMCHYKMKVL SEGIQTIENP YGYIPGNMPM NHLILSDCSP
460 470 480 490
YTLGALVALY EHKIFEQSVI WNINPFDQPG IESAKSAHRE ITLSSES
Length:497
Mass (Da):56,092
Last modified:May 1, 2000 - v1
Checksum:i8CDA94027718310C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007311 Genomic DNA. Translation: CAB65205.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007311 Genomic DNA. Translation: CAB65205.1.

3D structure databases

ProteinModelPortaliQ9RDY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi297246.lpp0825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional characterization of a 30 kb gene locus required for lipopolysaccharide biosynthesis in Legionella pneumophila."
    Lueneberg E., Zetzmann N., Hartmann M., Knirel Y.A., Kooistra O., Zaehringer U., Helbig J., Frosch M.
    Int. J. Med. Microbiol. 290:37-49(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43109 / NCTC 12008 / RC1 / Olda / Serogroup 1.

Entry informationi

Entry nameiG6PI_LEGPN
AccessioniPrimary (citable) accession number: Q9RDY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.