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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei737 – 7371ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SCO2571
ORF Names:SCC123.09c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Leucine--tRNA ligasePRO_0000152093Add
BLAST

Proteomic databases

PRIDEiQ9RDL5.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2571.

Structurei

3D structure databases

ProteinModelPortaliQ9RDL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi71 – 8212"HIGH" regionAdd
BLAST
Motifi734 – 7385"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
InParanoidiQ9RDL5.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.
PhylomeDBiQ9RDL5.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RDL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETNPAATA PVSADAAPHR YTAAMAAEIE ARWQDFWDAE GTYAAPNPKG
60 70 80 90 100
DLAGDPELVA KPKKFIMDMF PYPSGAGLHV GHPLGYIATD VFARFQRMTG
110 120 130 140 150
HNVLHTLGFD AFGLPAEQYA VQTGTHPRVS TEANMKNMQS QLRRLGLGHD
160 170 180 190 200
RRRSFATIDP EYYKWTQWIF LQIFNSWYDD EAKKARPIAE LVAQFASGER
210 220 230 240 250
EVPGHAGRAW SSLSEAERAD VLGEYRLAYA SDAPVNWCPG LGTVLANEEV
260 270 280 290 300
TADGRSERGN FPVFKSKLRQ WNMRITAYAD RLLDDLDQLD WPEAIKLQQR
310 320 330 340 350
NWIGRSEGAR VDFPVDGERI TVFTTRPDTL FGATYMVLAP EHPLVEKFTP
360 370 380 390 400
AVWPEGTRDA WTGGHATPTE AVAAYRAQAA SKSDVERQAE AKDKTGVFIG
410 420 430 440 450
AYATNPVNGE QVPVFVADYV LMGYGTGAIM AVPAHDSRDF EFARAFELPV
460 470 480 490 500
RCVVEPTDGR GTDTSTWDEA FASYDAKIVN SSGTDVSLDG LGVVEAKERV
510 520 530 540 550
TEWLERAGAG AGTVNFRLRD WLFSRQRYWG EPFPIVYDED GIAHPLPDSM
560 570 580 590 600
LPLELPEVED YSPRTFDPDD ADTKPETPLS RNEDWVHVTL DLGDGRGPRK
610 620 630 640 650
YRRETNTMPN WAGSCWYELR YLDPHNGERL VDPEIEQYWM GPREGLPHGG
660 670 680 690 700
VDLYVGGAEH AVLHLLYARF WSKVLFDLGH VSSAEPFHKL FNQGMIQAYV
710 720 730 740 750
YRDSRGIAVP AAEVEERDGA YYYQGEKVSR LLGKMGKSLK NAVTPDEICA
760 770 780 790 800
EYGADTLRLY EMAMGPLDVS RPWDTRAVVG QFRLLQRLWR NVVDEDTGEL
810 820 830 840 850
SVADVAESDI DAGTLRALHK AVDGVRQDLE GMRFNTAIAK VTELNNHLTK
860 870 880 890 900
AGGPVPRSVA ERLVLLVAPL APHVAEELWR KLGHESSVVH EDFPVADPAY
910 920 930 940 950
VVDETVTCVV QIKGKVKARL EVAPSISEDD LEKAALADEK VVAALGGAGI
960
RKVIVRAPKL VNIVPA
Length:966
Mass (Da):107,128
Last modified:May 1, 2000 - v1
Checksum:i87C81658A6C12B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939113 Genomic DNA. Translation: CAB66249.1.
RefSeqiNP_626809.1. NC_003888.3.
WP_003976232.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB66249; CAB66249; CAB66249.
GeneIDi1098005.
KEGGisco:SCO2571.
PATRICi23734822. VBIStrCoe124346_2616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939113 Genomic DNA. Translation: CAB66249.1.
RefSeqiNP_626809.1. NC_003888.3.
WP_003976232.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9RDL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO2571.

Proteomic databases

PRIDEiQ9RDL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB66249; CAB66249; CAB66249.
GeneIDi1098005.
KEGGisco:SCO2571.
PATRICi23734822. VBIStrCoe124346_2616.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
InParanoidiQ9RDL5.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.
PhylomeDBiQ9RDL5.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiSYL_STRCO
AccessioniPrimary (citable) accession number: Q9RDL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.