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Q9RDL5 (SYL_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:SCO2571
ORF Names:SCC123.09c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length966 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 966966Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152093

Regions

Motif71 – 8212"HIGH" region HAMAP-Rule MF_00049
Motif734 – 7385"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RDL5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 87C81658A6C12B87

FASTA966107,128
        10         20         30         40         50         60 
MSETNPAATA PVSADAAPHR YTAAMAAEIE ARWQDFWDAE GTYAAPNPKG DLAGDPELVA 

        70         80         90        100        110        120 
KPKKFIMDMF PYPSGAGLHV GHPLGYIATD VFARFQRMTG HNVLHTLGFD AFGLPAEQYA 

       130        140        150        160        170        180 
VQTGTHPRVS TEANMKNMQS QLRRLGLGHD RRRSFATIDP EYYKWTQWIF LQIFNSWYDD 

       190        200        210        220        230        240 
EAKKARPIAE LVAQFASGER EVPGHAGRAW SSLSEAERAD VLGEYRLAYA SDAPVNWCPG 

       250        260        270        280        290        300 
LGTVLANEEV TADGRSERGN FPVFKSKLRQ WNMRITAYAD RLLDDLDQLD WPEAIKLQQR 

       310        320        330        340        350        360 
NWIGRSEGAR VDFPVDGERI TVFTTRPDTL FGATYMVLAP EHPLVEKFTP AVWPEGTRDA 

       370        380        390        400        410        420 
WTGGHATPTE AVAAYRAQAA SKSDVERQAE AKDKTGVFIG AYATNPVNGE QVPVFVADYV 

       430        440        450        460        470        480 
LMGYGTGAIM AVPAHDSRDF EFARAFELPV RCVVEPTDGR GTDTSTWDEA FASYDAKIVN 

       490        500        510        520        530        540 
SSGTDVSLDG LGVVEAKERV TEWLERAGAG AGTVNFRLRD WLFSRQRYWG EPFPIVYDED 

       550        560        570        580        590        600 
GIAHPLPDSM LPLELPEVED YSPRTFDPDD ADTKPETPLS RNEDWVHVTL DLGDGRGPRK 

       610        620        630        640        650        660 
YRRETNTMPN WAGSCWYELR YLDPHNGERL VDPEIEQYWM GPREGLPHGG VDLYVGGAEH 

       670        680        690        700        710        720 
AVLHLLYARF WSKVLFDLGH VSSAEPFHKL FNQGMIQAYV YRDSRGIAVP AAEVEERDGA 

       730        740        750        760        770        780 
YYYQGEKVSR LLGKMGKSLK NAVTPDEICA EYGADTLRLY EMAMGPLDVS RPWDTRAVVG 

       790        800        810        820        830        840 
QFRLLQRLWR NVVDEDTGEL SVADVAESDI DAGTLRALHK AVDGVRQDLE GMRFNTAIAK 

       850        860        870        880        890        900 
VTELNNHLTK AGGPVPRSVA ERLVLLVAPL APHVAEELWR KLGHESSVVH EDFPVADPAY 

       910        920        930        940        950        960 
VVDETVTCVV QIKGKVKARL EVAPSISEDD LEKAALADEK VVAALGGAGI RKVIVRAPKL 


VNIVPA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939113 Genomic DNA. Translation: CAB66249.1.
RefSeqNP_626809.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9RDL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO2571.

Proteomic databases

PRIDEQ9RDL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB66249; CAB66249; CAB66249.
GeneID1098005.
KEGGsco:SCO2571.
PATRIC23734822. VBIStrCoe124346_2616.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.
PhylomeDBQ9RDL5.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_STRCO
AccessionPrimary (citable) accession number: Q9RDL5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries