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Q9RD27

- DEF1_STRCO

UniProt

Q9RD27 - DEF1_STRCO

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Protein

Peptide deformylase 1

Gene

def1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261IronUniRule annotation
Metal bindingi168 – 1681IronUniRule annotation
Active sitei169 – 1691UniRule annotation
Metal bindingi172 – 1721IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:SCO0883
ORF Names:SCM1.16
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Peptide deformylase 1PRO_0000082852Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO0883.

Structurei

3D structure databases

ProteinModelPortaliQ9RD27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
InParanoidiQ9RD27.
KOiK01462.
OMAiGWQARIV.
OrthoDBiEOG664CMF.
PhylomeDBiQ9RD27.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RD27 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTPSDRVPL AERVEELLAV GGPLPIVAAG DPVLRRAAEP YDGQVAPALF
60 70 80 90 100
ERFVEALRLT MHAAPGVGLA APQVGVGLRV AVIEDPAPVP DEVRVARGRV
110 120 130 140 150
PQPFRVLVNP SYEPAGAGRA AFFEGCLSVP GWQAVVARHA EVRLRAHDEH
160 170 180 190 200
GRAVDEVFAG WPARIVQHET DHLDGTLYLD RAELRSLASN AAMAELWSQP
210
TPRRAASALG FELPGPAA
Length:218
Mass (Da):23,198
Last modified:May 1, 2000 - v1
Checksum:i7F45248A0797288D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939107 Genomic DNA. Translation: CAB62674.1.
RefSeqiNP_625182.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB62674; CAB62674; CAB62674.
GeneIDi1096306.
KEGGisco:SCO0883.
PATRICi23731304. VBIStrCoe124346_0874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939107 Genomic DNA. Translation: CAB62674.1 .
RefSeqi NP_625182.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9RD27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO0883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB62674 ; CAB62674 ; CAB62674 .
GeneIDi 1096306.
KEGGi sco:SCO0883.
PATRICi 23731304. VBIStrCoe124346_0874.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
InParanoidi Q9RD27.
KOi K01462.
OMAi GWQARIV.
OrthoDBi EOG664CMF.
PhylomeDBi Q9RD27.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiDEF1_STRCO
AccessioniPrimary (citable) accession number: Q9RD27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3