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Q9RD27

- DEF1_STRCO

UniProt

Q9RD27 - DEF1_STRCO

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Protein
Peptide deformylase 1
Gene
def1, SCO0883, SCM1.16
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261Iron By similarity
Metal bindingi168 – 1681Iron By similarity
Active sitei169 – 1691 By similarity
Metal bindingi172 – 1721Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1 (EC:3.5.1.88)
Short name:
PDF 1
Alternative name(s):
Polypeptide deformylase 1
Gene namesi
Name:def1
Ordered Locus Names:SCO0883
ORF Names:SCM1.16
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Peptide deformylase 1UniRule annotation
PRO_0000082852Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO0883.

Structurei

3D structure databases

ProteinModelPortaliQ9RD27.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiGWQARIV.
OrthoDBiEOG664CMF.
PhylomeDBiQ9RD27.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RD27-1 [UniParc]FASTAAdd to Basket

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MGTPSDRVPL AERVEELLAV GGPLPIVAAG DPVLRRAAEP YDGQVAPALF    50
ERFVEALRLT MHAAPGVGLA APQVGVGLRV AVIEDPAPVP DEVRVARGRV 100
PQPFRVLVNP SYEPAGAGRA AFFEGCLSVP GWQAVVARHA EVRLRAHDEH 150
GRAVDEVFAG WPARIVQHET DHLDGTLYLD RAELRSLASN AAMAELWSQP 200
TPRRAASALG FELPGPAA 218
Length:218
Mass (Da):23,198
Last modified:May 1, 2000 - v1
Checksum:i7F45248A0797288D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939107 Genomic DNA. Translation: CAB62674.1.
RefSeqiNP_625182.1. NC_003888.3.
WP_011027414.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB62674; CAB62674; CAB62674.
GeneIDi1096306.
KEGGisco:SCO0883.
PATRICi23731304. VBIStrCoe124346_0874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939107 Genomic DNA. Translation: CAB62674.1 .
RefSeqi NP_625182.1. NC_003888.3.
WP_011027414.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9RD27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO0883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB62674 ; CAB62674 ; CAB62674 .
GeneIDi 1096306.
KEGGi sco:SCO0883.
PATRICi 23731304. VBIStrCoe124346_0874.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi GWQARIV.
OrthoDBi EOG664CMF.
PhylomeDBi Q9RD27.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiDEF1_STRCO
AccessioniPrimary (citable) accession number: Q9RD27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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