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Q9RD27

- DEF1_STRCO

UniProt

Q9RD27 - DEF1_STRCO

Protein

Peptide deformylase 1

Gene

def1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi126 – 1261IronUniRule annotation
    Metal bindingi168 – 1681IronUniRule annotation
    Active sitei169 – 1691UniRule annotation
    Metal bindingi172 – 1721IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 1UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 1UniRule annotation
    Gene namesi
    Name:def1UniRule annotation
    Ordered Locus Names:SCO0883
    ORF Names:SCM1.16
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Peptide deformylase 1PRO_0000082852Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO0883.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RD27.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiGWQARIV.
    OrthoDBiEOG664CMF.
    PhylomeDBiQ9RD27.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RD27-1 [UniParc]FASTAAdd to Basket

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    MGTPSDRVPL AERVEELLAV GGPLPIVAAG DPVLRRAAEP YDGQVAPALF    50
    ERFVEALRLT MHAAPGVGLA APQVGVGLRV AVIEDPAPVP DEVRVARGRV 100
    PQPFRVLVNP SYEPAGAGRA AFFEGCLSVP GWQAVVARHA EVRLRAHDEH 150
    GRAVDEVFAG WPARIVQHET DHLDGTLYLD RAELRSLASN AAMAELWSQP 200
    TPRRAASALG FELPGPAA 218
    Length:218
    Mass (Da):23,198
    Last modified:May 1, 2000 - v1
    Checksum:i7F45248A0797288D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939107 Genomic DNA. Translation: CAB62674.1.
    RefSeqiNP_625182.1. NC_003888.3.
    WP_011027414.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB62674; CAB62674; CAB62674.
    GeneIDi1096306.
    KEGGisco:SCO0883.
    PATRICi23731304. VBIStrCoe124346_0874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939107 Genomic DNA. Translation: CAB62674.1 .
    RefSeqi NP_625182.1. NC_003888.3.
    WP_011027414.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9RD27.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO0883.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB62674 ; CAB62674 ; CAB62674 .
    GeneIDi 1096306.
    KEGGi sco:SCO0883.
    PATRICi 23731304. VBIStrCoe124346_0874.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi GWQARIV.
    OrthoDBi EOG664CMF.
    PhylomeDBi Q9RD27.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiDEF1_STRCO
    AccessioniPrimary (citable) accession number: Q9RD27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3