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Protein

Exotoxin translocation ATP-binding protein PaxB

Gene

paxB

Organism
Pasteurella aerogenes
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex PaxBD involved in PaxA export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).Curated

Catalytic activityi

ATP + H2O + peptide(In) = ADP + phosphate + peptide(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi506 – 513ATP8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exotoxin translocation ATP-binding protein PaxB (EC:3.6.3.43)
Gene namesi
Name:paxB
OrganismiPasteurella aerogenes
Taxonomic identifieri749 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceae

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei157 – 177HelicalAdd BLAST21
Transmembranei195 – 215HelicalAdd BLAST21
Transmembranei273 – 293HelicalAdd BLAST21
Transmembranei299 – 319HelicalAdd BLAST21
Transmembranei392 – 412HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923891 – 711Exotoxin translocation ATP-binding protein PaxBAdd BLAST711

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9RCG7.
SMRiQ9RCG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 129Peptidase C39Add BLAST129
Domaini158 – 440ABC transmembrane type-1Add BLAST283
Domaini472 – 707ABC transporterAdd BLAST236

Domaini

In PaxB the peptidase C39 domain, the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR010132. ATPase_T1SS_HlyB.
IPR027417. P-loop_NTPase.
IPR005074. Peptidase_C39.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01846. type_I_sec_HlyB. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RCG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLMSFKQK NDYGLHALVI LAQYHNIAVS PEEIKHKFDP EGKGIDLVAW
60 70 80 90 100
LLAAKSFELK AKKVKKSIDR LPFIHLPALI WRDDGQHFIL TKIDTQTNRY
110 120 130 140 150
LIFDLEERNP KVLSAVEFQQ VFQGNVILLT SRASIMGKLA KFDFTWFIPA
160 170 180 190 200
IIKYRKIFVE VMIVSIFLQL FALITPLFFQ VVMDKVLVHR GFSTLNVITV
210 220 230 240 250
ALAIVVIFEI VLSGLRTYVF SHSTSRIDVE LGAKLFRHLL ALPISYFENR
260 270 280 290 300
RVGDTVARVR ELDQIRNFLT GQALTSVLDL LFSFIFFAVM WYYSPKLTIV
310 320 330 340 350
ILLSLPCYIA WSIFISPILR RRLDEKFTRN ADNQAFLVES VTAIDTIKAL
360 370 380 390 400
AVTPQMTNIW DKQLASYVSA DFRVTVLATI GQQGVQLIQK TVMIINLWLG
410 420 430 440 450
AHLVISGDLS IGQLIAFNML SGQVIAPVIR LAQLWQDFQQ VGISITRLGD
460 470 480 490 500
VLNAPTENFQ GKLSLPEING DVTFKNIRFR YKPDAPIILN DVNLTIKQGE
510 520 530 540 550
VIGIVGRSGS GKSTLTKLLQ RFYIPENGQV LIDGHDLALA DPNWLRRQIG
560 570 580 590 600
VVLQDNVLLN RSIRDNIALT DPSMPMEQVI HAAKLAGAHD FISELREGYN
610 620 630 640 650
TMVGEQGAGL SGGQRQRIAI ARALVNNPRI LIFDEATSAL DYESEHIIMR
660 670 680 690 700
NMQQICHGRT VIIIAHRLST VRKADRIIVM EKGHIVERGK HSELLENKDG
710
LYYYLNQLQS I
Length:711
Mass (Da):80,424
Last modified:May 1, 2000 - v1
Checksum:i9A19D2156F648E2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66588 Genomic DNA. Translation: AAF15371.1.

Similar proteinsi

Entry informationi

Entry nameiPAXB_PASAE
AccessioniPrimary (citable) accession number: Q9RCG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Tyr-13 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus this protein is presumed to be without peptidase activity.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families