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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi153 – 160ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-1-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:BH0001
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141291 – 449Chromosomal replication initiator protein DnaAAdd BLAST449

Interactioni

Protein-protein interaction databases

STRINGi272558.BH0001

Structurei

3D structure databases

ProteinModelPortaliQ9RCA2
SMRiQ9RCA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
KOiK02313
OMAiREFNPLF
OrthoDBiPOG091H02FF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RCA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENIHDLWER ALKSMEKKVS KPSFETWLKQ TKANSIEDST IIITAPNEFA
60 70 80 90 100
RDWLEKHYDE LISETIDDLT GVRLYPKFVI PTSQLDEPFV EQELKKPMKQ
110 120 130 140 150
PPAQNGEMPN NMLNDKYTFD TFVIGSGNRF AHAASLAVAE APAKAYNPLF
160 170 180 190 200
IYGGVGLGKT HLMHAIGHYV MDHNPNAKVV YLSSEKFTNE FINAIRDNKA
210 220 230 240 250
VNFRNKYRNV DVLLIDDIQF LAGKEQTQEE FFHTFNALHE DNKQIVISSD
260 270 280 290 300
RPPKEIPTLE DRLRSRFEWG LITDITPPDL ETRIAILRKK AKAENLDIPN
310 320 330 340 350
EVMLYIANQI DTNIRELEGA LIRVVAYSSL INQDMNADLA AEALKDIIPN
360 370 380 390 400
AKPRVLTITD IQKTVGEYFH VKLEDFKAKK RTKSVAFPRQ IAMYLSRELT
410 420 430 440
DASLPKIGSE FGGRDHTTVI HAHEKISKLL STDQELQDKI QDISDKLRS
Length:449
Mass (Da):51,263
Last modified:May 1, 2000 - v1
Checksum:iD75C00BBF110A614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013492 Genomic DNA Translation: BAA82685.1
BA000004 Genomic DNA Translation: BAB03720.1
PIRiA83650
RefSeqiWP_010896185.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB03720; BAB03720; BAB03720
KEGGibha:BH0001

Similar proteinsi

Entry informationi

Entry nameiDNAA_BACHD
AccessioniPrimary (citable) accession number: Q9RCA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health