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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

pdxA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Binding sitei141SubstrateBy similarity1
Metal bindingi170Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi214Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi269Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei277SubstrateBy similarity1
Binding sitei295SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.408By similarity)
Gene namesi
Name:pdxA
Ordered Locus Names:BH0804
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001887971 – 334Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST334

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272558.BH0804.

Structurei

3D structure databases

ProteinModelPortaliQ9RC88.
SMRiQ9RC88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000040097.
KOiK00097.
OMAiAPVHKGV.
OrthoDBiPOG091H03XD.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RC88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKPIIAIP MGDPAGIGPE ITVGALNKKE LYDVANPVVI GHGDMLEKML
60 70 80 90 100
PVMKADLTIN RITTVDEAMF EYGTIDVIHL DNLNVAEVKM GTVQAQCGKA
110 120 130 140 150
AFEYIRHAVQ LANDKKVDAL ATTPINKESL KAAEVPYIGH TEMLADLTKT
160 170 180 190 200
EDPLTMFEVH SMRIFFLTRH LSLKDAIDQM TKERVHDYLL RCDKALEKLG
210 220 230 240 250
VKERRFAVAG LNPHSGENGL FGREEMDEIT PGIELAKKDG INAVGPVPAD
260 270 280 290 300
SVFHHALNGR YDAVLSLYHD QGHIAAKMTD FERTISITNG LPFLRTSVDH
310 320 330
GTAFDIAGKG IASTVSMEEC IKLAAKYAPH FVTA
Length:334
Mass (Da):36,632
Last modified:May 1, 2000 - v1
Checksum:i24436A1866079820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024550 Genomic DNA. Translation: BAA83911.1.
BA000004 Genomic DNA. Translation: BAB04523.1.
PIRiD83750.
RefSeqiWP_010896977.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB04523; BAB04523; BAB04523.
KEGGibha:BH0804.

Similar proteinsi

Entry informationi

Entry nameiPDXA2_BACHD
AccessioniPrimary (citable) accession number: Q9RC88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families