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Q9RC88

- PDXA_BACHD

UniProt

Q9RC88 - PDXA_BACHD

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, BH0804
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Metal bindingi170 – 1701Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi214 – 2141Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi269 – 2691Divalent metal cation; shared with dimeric partner By similarity
Binding sitei277 – 2771Substrate By similarity
Binding sitei295 – 2951Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-862-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:BH0804
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3343344-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_0000188797Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH0804.

Structurei

3D structure databases

ProteinModelPortaliQ9RC88.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000040097.
KOiK00097.
OMAiAIPMGDP.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RC88-1 [UniParc]FASTAAdd to Basket

« Hide

MNKKPIIAIP MGDPAGIGPE ITVGALNKKE LYDVANPVVI GHGDMLEKML    50
PVMKADLTIN RITTVDEAMF EYGTIDVIHL DNLNVAEVKM GTVQAQCGKA 100
AFEYIRHAVQ LANDKKVDAL ATTPINKESL KAAEVPYIGH TEMLADLTKT 150
EDPLTMFEVH SMRIFFLTRH LSLKDAIDQM TKERVHDYLL RCDKALEKLG 200
VKERRFAVAG LNPHSGENGL FGREEMDEIT PGIELAKKDG INAVGPVPAD 250
SVFHHALNGR YDAVLSLYHD QGHIAAKMTD FERTISITNG LPFLRTSVDH 300
GTAFDIAGKG IASTVSMEEC IKLAAKYAPH FVTA 334
Length:334
Mass (Da):36,632
Last modified:May 1, 2000 - v1
Checksum:i24436A1866079820
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024550 Genomic DNA. Translation: BAA83911.1.
BA000004 Genomic DNA. Translation: BAB04523.1.
PIRiD83750.
RefSeqiNP_241670.1. NC_002570.2.
WP_010896977.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB04523; BAB04523; BAB04523.
GeneIDi892178.
KEGGibha:BH0804.
PATRICi18938608. VBIBacHal18977_0842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024550 Genomic DNA. Translation: BAA83911.1 .
BA000004 Genomic DNA. Translation: BAB04523.1 .
PIRi D83750.
RefSeqi NP_241670.1. NC_002570.2.
WP_010896977.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9RC88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH0804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB04523 ; BAB04523 ; BAB04523 .
GeneIDi 892178.
KEGGi bha:BH0804.
PATRICi 18938608. VBIBacHal18977_0842.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000040097.
KOi K00097.
OMAi AIPMGDP.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci BHAL272558:GJC5-862-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic analysis of the chromosome of alkaliphilic Bacillus halodurans C-125."
    Takami H., Takaki Y., Nakasone K., Sakiyama T., Maeno G., Sasaki R., Hirama C., Fuji F., Masui N.
    Extremophiles 3:227-233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.
  2. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiPDXA_BACHD
AccessioniPrimary (citable) accession number: Q9RC88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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