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Protein

Sensor protein CitS

Gene

citS

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system CitT/CitS. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg2+-citrate complex (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 661.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein CitS (EC:2.7.13.3)
Gene namesi
Name:citS
Ordered Locus Names:BH3839
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 174ExtracellularSequence analysisAdd BLAST140
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 538CytoplasmicSequence analysisAdd BLAST343

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747341 – 538Sensor protein CitSAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3839.

Structurei

3D structure databases

ProteinModelPortaliQ9RC53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 282PASAdd BLAST67
Domaini339 – 534Histidine kinasePROSITE-ProRule annotationAdd BLAST196

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CEQ. Bacteria.
COG3290. LUCA.
HOGENOMiHOG000241936.
KOiK11637.
OMAiQETAHYQ.
OrthoDBiPOG091B079E.

Family and domain databases

CDDicd00130. PAS. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR033463. sCache_3.
IPR029151. Sensor-like.
IPR004358. Sig_transdc_His_kin-like_C.
IPR016120. Sig_transdc_His_kin_SpoOB.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00989. PAS. 1 hit.
PF17203. sCache_3_2. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00091. PAS. 1 hit.
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF55890. SSF55890. 1 hit.
PROSITEiView protein in PROSITE
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RC53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRLFPLTF SAKMMGFIAL LIIAMFVLLG VFLNEQYART LEEQMGERAL
60 70 80 90 100
SVAQAVALIP ELREAFSAER PDEIIQPIAE SIRVETGAEF IVVGNTDLIR
110 120 130 140 150
YAHPLPERIG QRMVGGDNER ALVHGESYVS KAVGSLGPSI RGKVPVFDDN
160 170 180 190 200
GKIIGIVSVG FLMEDIQQVI GERLIAMWQI VVVIMILGLM GTWLVANTVK
210 220 230 240 250
KATLGLEPEE IGQQFQQKEA ILQSIHEGVI AVNKEGKVTL FNQAAMKYVD
260 270 280 290 300
PELDKEDVLG RHVTDLVKHT RLPEVLQVGK GQYDQELRIG DKQAVVNRVP
310 320 330 340 350
IYYDHEIVGA VATFRDRNEI KKLSEELTNV KNYADALRAQ THEFSNKLNT
360 370 380 390 400
ISGFLQLGKI DEAVDFIQKE RKIQQEWIHF FIERVNDPTV SAVLLGKISQ
410 420 430 440 450
AQELGIDVDI DPSSQLLTPL QERQQELLVT MIGNLLENAF DALLASGIEN
460 470 480 490 500
KKIYISFTDM GDDFIFEVED NGPGIPPQLM ESIFEEGFST KEGTHRGFGL
510 520 530
ALVKKAVHEL GGAIFLEEGE LGGACFVLTI PKHEAKEG
Length:538
Mass (Da):59,814
Last modified:May 1, 2000 - v1
Checksum:iA679B7A0D7662668
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024561 Genomic DNA. Translation: BAA83946.1.
BA000004 Genomic DNA. Translation: BAB07558.1.
PIRiG84129.
RefSeqiWP_010899964.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB07558; BAB07558; BAB07558.
KEGGibha:BH3839.
PATRICi18944996. VBIBacHal18977_3996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024561 Genomic DNA. Translation: BAA83946.1.
BA000004 Genomic DNA. Translation: BAB07558.1.
PIRiG84129.
RefSeqiWP_010899964.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9RC53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH3839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB07558; BAB07558; BAB07558.
KEGGibha:BH3839.
PATRICi18944996. VBIBacHal18977_3996.

Phylogenomic databases

eggNOGiENOG4105CEQ. Bacteria.
COG3290. LUCA.
HOGENOMiHOG000241936.
KOiK11637.
OMAiQETAHYQ.
OrthoDBiPOG091B079E.

Enzyme and pathway databases

BRENDAi2.7.13.3. 661.

Family and domain databases

CDDicd00130. PAS. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR033463. sCache_3.
IPR029151. Sensor-like.
IPR004358. Sig_transdc_His_kin-like_C.
IPR016120. Sig_transdc_His_kin_SpoOB.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00989. PAS. 1 hit.
PF17203. sCache_3_2. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00091. PAS. 1 hit.
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF55890. SSF55890. 1 hit.
PROSITEiView protein in PROSITE
PS50109. HIS_KIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCITS_BACHD
AccessioniPrimary (citable) accession number: Q9RC53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: February 15, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.