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Q9RB37 (UPPP_FLAJ1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:Fjoh_0569
OrganismFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]
Taxonomic identifier376686 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151142

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane245 – 26521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9RB37 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 84A4BF72F6145B0F

FASTA26529,118
        10         20         30         40         50         60 
MNTLQAIVLA VIEGITEFLP VSSTGHMIIA SSFFGIAHED FTKLFTIVIQ LGAILSVVVL 

        70         80         90        100        110        120 
YFKRFFQTLD FYFKLLVAFI PAVVLGLLLS DFIDGLLENP VTVAVSLLIG GLILLKVDEW 

       130        140        150        160        170        180 
FNNPNAAETS QKITYLQALK IGLFQCIAMI PGVSRSGASI VGGMSQKLSR TTAAEFSFFL 

       190        200        210        220        230        240 
AVPTMLGATV KKCYDYYKAG FELSHDQVNI LIIGNVVAFI VALLAIKTFI SFLTKNGFKV 

       250        260 
FGYYRIIAGI ILLLIHFFIH PLTII 

« Hide

References

« Hide 'large scale' references
[1]"Transposon insertions in the Flavobacterium johnsoniae ftsX gene disrupt gliding motility and cell division."
Kempf M.J., McBride M.J.
J. Bacteriol. 182:1671-1679(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of Flavobacterium johnsoniae UW101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17061 / DSM 2064 / UW101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF169967 Genomic DNA. Translation: AAD50462.1.
CP000685 Genomic DNA. Translation: ABQ03604.1.
RefSeqYP_001192923.1. NC_009441.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING376686.Fjoh_0569.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ03604; ABQ03604; Fjoh_0569.
GeneID5089515.
KEGGfjo:Fjoh_0569.
PATRIC21895401. VBIFlaJoh53613_0587.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK2788038.

Enzyme and pathway databases

BioCycFJOH376686:GIXN-588-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_FLAJ1
AccessionPrimary (citable) accession number: Q9RB37
Secondary accession number(s): A5FMG6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families