Reviewed, UniProtKB/Swiss-Prot Q9RB10 (DSBA_PECCC)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbA

Gene names

Name:

dsbA

Organism

Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)

Taxonomic identifier

555 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins such as phoA or ompA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by dsbB. It is required for pilus biogenesis.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 207	188	Thiol:disulfide interchange protein dsbA		PRO_0000034258
Regions
	Domain	20 – 149	130	Thioredoxin
Amino acid modifications
	Disulfide bond	49 ↔ 52		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9RB10-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 18BC5256E1EC414F	FASTA	207	23,078
	10 20 30 40 50 60 MKKLWFALIG VVLAFSASAA EFSDGKQYVE LDKPATQEPQ VLEFFSFYCP HCYQFEQVYH 70 80 90 100 110 120 VPDAVKKALP EGTKMTRYHV DFLGPLGKNL TQAWAVAMAL GVEDKITPLM FDAVQKTQTV 130 140 150 160 170 180 QKPEDIREVF VKAGVSAEEF DGALNSFVVK SLVAQQEKAA ADLQLRGVPA MFVNGKYMIK 190 200 NDGLDTSSMD GYVKQYADVV KFLITKK

References

[1]

"Erwinia carotovora DsbA mutants: evidence for a periplasmic-stress signal transduction system affecting transcription of genes encoding secreted proteins." Vincent-Sealy L.V., Thomas J.D., Commander P., Salmond G.P.C. Microbiology 145:1945-1958(1999) [PubMed: 10463161] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SCRI 193.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF146615 Genomic DNA. Translation: AAD47613.1.
3D structure databases
HSSP	HSSP built from PDB template 1A23 based on UniProtKB P24991.
ModBase	Search...
Family and domain databases
InterPro	IPR001853. OxRdtase_DSBA. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_PECCC

Accession

Primary (citable) accession number: Q9RB10

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	March 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)